BRD-K53780220_N-((1H-benzo[d]imidazol-2-yl)methyl)-2-morpholino-9-(thiophen-3-yl)-9H-purin-6-amine_PC3_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

57 genes differentially expressed following the BRD-K53780220_N-((1H-benzo[d]imidazol-2-yl)methyl)-2-morpholino-9-(thiophen-3-yl)-9H-purin-6-amine_PC3_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTR2 ARP2 actin-related protein 2 homolog (yeast)
AEBP1 AE binding protein 1
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ANXA4 annexin A4
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
CECR1 cat eye syndrome chromosome region, candidate 1
CERS6 ceramide synthase 6
CFB complement factor B
CKB creatine kinase, brain
COL11A1 collagen, type XI, alpha 1
COL4A5 collagen, type IV, alpha 5
CPA3 carboxypeptidase A3 (mast cell)
DCN decorin
DSP desmoplakin
DUSP1 dual specificity phosphatase 1
FGFR2 fibroblast growth factor receptor 2
HIST2H2BE histone cluster 2, H2be
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
KRT19 keratin 19, type I
NR4A2 nuclear receptor subfamily 4, group A, member 2
NUPR1 nuclear protein, transcriptional regulator, 1
ORM1 orosomucoid 1
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PBX3 pre-B-cell leukemia homeobox 3
PCP4 Purkinje cell protein 4
PON3 paraoxonase 3
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RHOBTB3 Rho-related BTB domain containing 3
S100A8 S100 calcium binding protein A8
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SEPT2 septin 2
TCEA2 transcription elongation factor A (SII), 2
TGFB1 transforming growth factor, beta 1
VTCN1 V-set domain containing T cell activation inhibitor 1
WLS wntless Wnt ligand secretion mediator

decreased expression

Symbol Name
ARMCX6 armadillo repeat containing, X-linked 6
CANT1 calcium activated nucleotidase 1
CCNA2 cyclin A2
CDC25A cell division cycle 25A
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
DUSP4 dual specificity phosphatase 4
EFNB2 ephrin-B2
FOSL1 FOS-like antigen 1
HOXC6 homeobox C6
JMJD6 jumonji domain containing 6
KRT7 keratin 7, type II
NET1 neuroepithelial cell transforming 1
NRIP1 nuclear receptor interacting protein 1
NUP62 nucleoporin 62kDa
RPS11 ribosomal protein S11
SMAD3 SMAD family member 3
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TIMP4 TIMP metallopeptidase inhibitor 4