BRD-K53780220_N-((1H-benzo[d]imidazol-2-yl)methyl)-2-morpholino-9-(thiophen-3-yl)-9H-purin-6-amine_PC3_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

121 genes differentially expressed following the BRD-K53780220_N-((1H-benzo[d]imidazol-2-yl)methyl)-2-morpholino-9-(thiophen-3-yl)-9H-purin-6-amine_PC3_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTA2 actin, alpha 2, smooth muscle, aorta
ADD3 adducin 3 (gamma)
AGR2 anterior gradient 2
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ANOS1 anosmin 1
ASPN asporin
C5AR1 complement component 5a receptor 1
C6ORF62 chromosome 6 open reading frame 62
CADM1 cell adhesion molecule 1
CD24 CD24 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CHGB chromogranin B
COL11A1 collagen, type XI, alpha 1
CSTA cystatin A (stefin A)
CXADR coxsackie virus and adenovirus receptor
CXCL13 chemokine (C-X-C motif) ligand 13
DACH1 dachshund family transcription factor 1
DCN decorin
DEFA4 defensin, alpha 4, corticostatin
DKK3 dickkopf WNT signaling pathway inhibitor 3
DLC1 DLC1 Rho GTPase activating protein
DPYSL3 dihydropyrimidinase-like 3
DSP desmoplakin
EIF4A1 eukaryotic translation initiation factor 4A1
EPCAM epithelial cell adhesion molecule
EREG epiregulin
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FHL1 four and a half LIM domains 1
FXYD3 FXYD domain containing ion transport regulator 3
G0S2 G0/G1 switch 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GATAD1 GATA zinc finger domain containing 1
GPNMB glycoprotein (transmembrane) nmb
HCAR3 hydroxycarboxylic acid receptor 3
HOPX HOP homeobox
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IFI27 interferon, alpha-inducible protein 27
IFITM1 interferon induced transmembrane protein 1
INHBA inhibin, beta A
KRT5 keratin 5, type II
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LPPR4 lipid phosphate phosphatase-related protein type 4
LUM lumican
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MMP12 matrix metallopeptidase 12
NGRN neugrin, neurite outgrowth associated
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
OAT ornithine aminotransferase
OLFM4 olfactomedin 4
PCBP2 poly(rC) binding protein 2
PERP PERP, TP53 apoptosis effector
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLS3 plastin 3
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
POSTN periostin, osteoblast specific factor
PRAME preferentially expressed antigen in melanoma
PRKCI protein kinase C, iota
PRR7 proline rich 7 (synaptic)
PTGER4 prostaglandin E receptor 4 (subtype EP4)
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SFN stratifin
SFRP4 secreted frizzled-related protein 4
SGK1 serum/glucocorticoid regulated kinase 1
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3
SPEN spen family transcriptional repressor
STC1 stanniocalcin 1
STK10 serine/threonine kinase 10
SULF1 sulfatase 1
TAGLN transgelin
TCF4 transcription factor 4
THBS2 thrombospondin 2
TYROBP TYRO protein tyrosine kinase binding protein
WIF1 WNT inhibitory factor 1

decreased expression

Symbol Name
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
CCNA2 cyclin A2
CD164 CD164 molecule, sialomucin
CDC25B cell division cycle 25B
CLTC clathrin, heavy chain (Hc)
ECI2 enoyl-CoA delta isomerase 2
EZR ezrin
FUS FUS RNA binding protein
GLOD4 glyoxalase domain containing 4
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
ITGA6 integrin, alpha 6
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KRT7 keratin 7, type II
LBR lamin B receptor
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MGLL monoglyceride lipase
MYBPC1 myosin binding protein C, slow type
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1
PHB prohibitin
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PSMD3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3
RBPJ recombination signal binding protein for immunoglobulin kappa J region
REXO2 RNA exonuclease 2
RNPS1 RNA binding protein S1, serine-rich domain
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SFRP1 secreted frizzled-related protein 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC35F2 solute carrier family 35, member F2
SOX9 SRY (sex determining region Y)-box 9
STAP1 signal transducing adaptor family member 1
TBL1X transducin (beta)-like 1X-linked
TES testin LIM domain protein
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TRAPPC3 trafficking protein particle complex 3
TWF2 twinfilin actin binding protein 2
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
USP22 ubiquitin specific peptidase 22
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa
YBX3 Y box binding protein 3
ZFP36L1 ZFP36 ring finger protein-like 1