BRD-K53780220_N-((1H-benzo[d]imidazol-2-yl)methyl)-2-morpholino-9-(thiophen-3-yl)-9H-purin-6-amine_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

114 genes differentially expressed following the BRD-K53780220_N-((1H-benzo[d]imidazol-2-yl)methyl)-2-morpholino-9-(thiophen-3-yl)-9H-purin-6-amine_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADGRG6 adhesion G protein-coupled receptor G6
AEBP1 AE binding protein 1
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALDOC aldolase C, fructose-bisphosphate
CD36 CD36 molecule (thrombospondin receptor)
CD9 CD9 molecule
CELF2 CUGBP, Elav-like family member 2
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COL11A1 collagen, type XI, alpha 1
COL3A1 collagen, type III, alpha 1
COL6A2 collagen, type VI, alpha 2
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT4 DNA-damage-inducible transcript 4
EDNRB endothelin receptor type B
EIF5A eukaryotic translation initiation factor 5A
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
GLO1 glyoxalase I
GPX1 glutathione peroxidase 1
HBB hemoglobin, beta
HLA-C major histocompatibility complex, class I, C
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IER3 immediate early response 3
KCTD12 potassium channel tetramerization domain containing 12
KIF5C kinesin family member 5C
LGMN legumain
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFE2L3 nuclear factor, erythroid 2-like 3
NID2 nidogen 2 (osteonidogen)
PBX3 pre-B-cell leukemia homeobox 3
PLAU plasminogen activator, urokinase
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RBPMS RNA binding protein with multiple splicing
RGS5 regulator of G-protein signaling 5
RPS4Y1 ribosomal protein S4, Y-linked 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
SNX10 sorting nexin 10
STEAP1 six transmembrane epithelial antigen of the prostate 1
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit
TMSB15A thymosin beta 15a
TPD52 tumor protein D52
TXNIP thioredoxin interacting protein
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VCAN versican
VIM vimentin
YES1 YES proto-oncogene 1, Src family tyrosine kinase

decreased expression

Symbol Name
ABLIM1 actin binding LIM protein 1
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
AURKA aurora kinase A
BAMBI BMP and activin membrane-bound inhibitor
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BCL6 B-cell CLL/lymphoma 6
CCNB2 cyclin B2
CDC45 cell division cycle 45
CDK7 cyclin-dependent kinase 7
CDKN3 cyclin-dependent kinase inhibitor 3
CLTB clathrin, light chain B
COG2 component of oligomeric golgi complex 2
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DLK1 delta-like 1 homolog (Drosophila)
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGR2 early growth response 2
EIF5 eukaryotic translation initiation factor 5
FAM57A family with sequence similarity 57, member A
FXYD3 FXYD domain containing ion transport regulator 3
GATA3 GATA binding protein 3
GPRC5A G protein-coupled receptor, class C, group 5, member A
GRWD1 glutamate-rich WD repeat containing 1
HIST1H2BK histone cluster 1, H2bk
HOXC6 homeobox C6
IDI1 isopentenyl-diphosphate delta isomerase 1
IFI27 interferon, alpha-inducible protein 27
IFRD1 interferon-related developmental regulator 1
IGL immunoglobulin lambda locus
ITGB1BP1 integrin beta 1 binding protein 1
JMJD6 jumonji domain containing 6
KLK11 kallikrein-related peptidase 11
KRT7 keratin 7, type II
MACF1 microtubule-actin crosslinking factor 1
MFSD10 major facilitator superfamily domain containing 10
MTF2 metal response element binding transcription factor 2
NRIP1 nuclear receptor interacting protein 1
PALLD palladin, cytoskeletal associated protein
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
POLR1D polymerase (RNA) I polypeptide D, 16kDa
PPIF peptidylprolyl isomerase F
RALGDS ral guanine nucleotide dissociation stimulator
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SLC38A1 solute carrier family 38, member 1
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
STC2 stanniocalcin 2
STK17A serine/threonine kinase 17a
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACSTD2 tumor-associated calcium signal transducer 2
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TFRC transferrin receptor
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TOR1A torsin family 1, member A (torsin A)
TRIM29 tripartite motif containing 29
TSKU tsukushi, small leucine rich proteoglycan
UBE3C ubiquitin protein ligase E3C
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)
ZNF512B zinc finger protein 512B