BRD-K53780220_N-((1H-benzo[d]imidazol-2-yl)methyl)-2-morpholino-9-(thiophen-3-yl)-9H-purin-6-amine_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

285 genes differentially expressed following the BRD-K53780220_N-((1H-benzo[d]imidazol-2-yl)methyl)-2-morpholino-9-(thiophen-3-yl)-9H-purin-6-amine_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
AAMDC adipogenesis associated, Mth938 domain containing
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ADD3 adducin 3 (gamma)
ADM adrenomedullin
ALB albumin
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ALDOB aldolase B, fructose-bisphosphate
ANGPTL2 angiopoietin-like 2
ANXA1 annexin A1
AQP1 aquaporin 1 (Colton blood group)
ARL4C ADP-ribosylation factor-like 4C
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
ASGR2 asialoglycoprotein receptor 2
ASPN asporin
BCHE butyrylcholinesterase
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BMP2 bone morphogenetic protein 2
CADM1 cell adhesion molecule 1
CASP1 caspase 1, apoptosis-related cysteine peptidase
CAV1 caveolin 1, caveolae protein, 22kDa
CCL2 chemokine (C-C motif) ligand 2
CCND2 cyclin D2
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD93 CD93 molecule
CHN2 chimerin 2
CLC Charcot-Leyden crystal galectin
CLEC2B C-type lectin domain family 2, member B
COL10A1 collagen, type X, alpha 1
COL11A1 collagen, type XI, alpha 1
COL1A2 collagen, type I, alpha 2
COL4A5 collagen, type IV, alpha 5
COL5A2 collagen, type V, alpha 2
COLEC12 collectin sub-family member 12
CTGF connective tissue growth factor
CXADR coxsackie virus and adenovirus receptor
DKK3 dickkopf WNT signaling pathway inhibitor 3
DPYSL3 dihydropyrimidinase-like 3
DSP desmoplakin
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
ECM1 extracellular matrix protein 1
ESM1 endothelial cell-specific molecule 1
EXPH5 exophilin 5
FAM129A family with sequence similarity 129, member A
FHL1 four and a half LIM domains 1
FHOD3 formin homology 2 domain containing 3
FLT1 fms-related tyrosine kinase 1
FRY furry homolog (Drosophila)
FST follistatin
GADD45A growth arrest and DNA-damage-inducible, alpha
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
GREM1 gremlin 1, DAN family BMP antagonist
HLA-B major histocompatibility complex, class I, B
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IFI16 interferon, gamma-inducible protein 16
IGFBP7 insulin-like growth factor binding protein 7
INHBA inhibin, beta A
IQGAP1 IQ motif containing GTPase activating protein 1
ITFG1 integrin alpha FG-GAP repeat containing 1
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KCNK12 potassium channel, two pore domain subfamily K, member 12
KIAA1462 KIAA1462
LAMP3 lysosomal-associated membrane protein 3
LRRC17 leucine rich repeat containing 17
MAOA monoamine oxidase A
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial
MEF2C myocyte enhancer factor 2C
MEIS1 Meis homeobox 1
MEIS2 Meis homeobox 2
MMP12 matrix metallopeptidase 12
MMP9 matrix metallopeptidase 9
MN1 meningioma (disrupted in balanced translocation) 1
MSN moesin
MT1E metallothionein 1E
MX1 MX dynamin-like GTPase 1
MXI1 MAX interactor 1, dimerization protein
MXRA5 matrix-remodelling associated 5
NCAM1 neural cell adhesion molecule 1
NELL2 NEL-like 2 (chicken)
NFE2 nuclear factor, erythroid 2
NRGN neurogranin (protein kinase C substrate, RC3)
OLFM4 olfactomedin 4
ORM1 orosomucoid 1
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PBX3 pre-B-cell leukemia homeobox 3
PCDH7 protocadherin 7
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDGFC platelet derived growth factor C
PECAM1 platelet/endothelial cell adhesion molecule 1
PLVAP plasmalemma vesicle associated protein
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RBP1 retinol binding protein 1, cellular
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RGCC regulator of cell cycle
RGS4 regulator of G-protein signaling 4
RGS5 regulator of G-protein signaling 5
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
SDC2 syndecan 2
SLCO3A1 solute carrier organic anion transporter family, member 3A1
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SOCS2 suppressor of cytokine signaling 2
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SST somatostatin
STC1 stanniocalcin 1
SULF1 sulfatase 1
TCF4 transcription factor 4
THBS1 thrombospondin 1
THBS2 thrombospondin 2
TMEM158 transmembrane protein 158 (gene/pseudogene)
TYROBP TYRO protein tyrosine kinase binding protein
VEGFA vascular endothelial growth factor A
VNN1 vanin 1
VTCN1 V-set domain containing T cell activation inhibitor 1
WNT5A wingless-type MMTV integration site family, member 5A
XIST X inactive specific transcript (non-protein coding)
ZFPM2 zinc finger protein, FOG family member 2

decreased expression

Symbol Name
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3
AGR2 anterior gradient 2
AGTR1 angiotensin II receptor, type 1
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
AMD1 adenosylmethionine decarboxylase 1
APOD apolipoprotein D
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ARMCX6 armadillo repeat containing, X-linked 6
ARMT1 acidic residue methyltransferase 1
ARPC4 actin related protein 2/3 complex, subunit 4, 20kDa
ASS1 argininosuccinate synthase 1
AURKA aurora kinase A
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
BAMBI BMP and activin membrane-bound inhibitor
BASP1 brain abundant, membrane attached signal protein 1
BCAS3 breast carcinoma amplified sequence 3
BTBD3 BTB (POZ) domain containing 3
BUB3 BUB3 mitotic checkpoint protein
CA12 carbonic anhydrase XII
CCL19 chemokine (C-C motif) ligand 19
CCNA2 cyclin A2
CCNB2 cyclin B2
CCNF cyclin F
CD24 CD24 molecule
CD59 CD59 molecule, complement regulatory protein
CDC123 cell division cycle 123
CDC20 cell division cycle 20
CDC25B cell division cycle 25B
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CHPT1 choline phosphotransferase 1
CLTC clathrin, heavy chain (Hc)
CLU clusterin
CNIH1 cornichon family AMPA receptor auxiliary protein 1
CP ceruloplasmin (ferroxidase)
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CTTN cortactin
CXCL12 chemokine (C-X-C motif) ligand 12
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DBF4 DBF4 zinc finger
DCK deoxycytidine kinase
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLD dihydrolipoamide dehydrogenase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EIF4E eukaryotic translation initiation factor 4E
EPS8 epidermal growth factor receptor pathway substrate 8
FAM35A family with sequence similarity 35, member A
FOXJ3 forkhead box J3
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GATA3 GATA binding protein 3
GCH1 GTP cyclohydrolase 1
GRWD1 glutamate-rich WD repeat containing 1
HEATR1 HEAT repeat containing 1
HN1 hematological and neurological expressed 1
HOXC6 homeobox C6
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IDI1 isopentenyl-diphosphate delta isomerase 1
IGFBP4 insulin-like growth factor binding protein 4
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
KDM5D lysine (K)-specific demethylase 5D
KIF2C kinesin family member 2C
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRT10 keratin 10, type I
KRT7 keratin 7, type II
KRT81 keratin 81, type II
KYNU kynureninase
LITAF lipopolysaccharide-induced TNF factor
LTF lactotransferrin
MARCKS myristoylated alanine-rich protein kinase C substrate
MARCKSL1 MARCKS-like 1
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MLF1 myeloid leukemia factor 1
MLPH melanophilin
MRPS30 mitochondrial ribosomal protein S30
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MUC5AC mucin 5AC, oligomeric mucus/gel-forming
MUC5B mucin 5B, oligomeric mucus/gel-forming
NBN nibrin
NFIB nuclear factor I/B
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NPY1R neuropeptide Y receptor Y1
NQO1 NAD(P)H dehydrogenase, quinone 1
NRIP1 nuclear receptor interacting protein 1
NUP62 nucleoporin 62kDa
OPN3 opsin 3
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PFKP phosphofructokinase, platelet
PIGC phosphatidylinositol glycan anchor biosynthesis, class C
PLK1 polo-like kinase 1
PNP purine nucleoside phosphorylase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha
PRPS2 phosphoribosyl pyrophosphate synthetase 2
PRSS23 protease, serine, 23
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
PTDSS1 phosphatidylserine synthase 1
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTGES prostaglandin E synthase
PUF60 poly-U binding splicing factor 60KDa
RAB22A RAB22A, member RAS oncogene family
RAE1 ribonucleic acid export 1
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBBP4 retinoblastoma binding protein 4
RNPS1 RNA binding protein S1, serine-rich domain
RPL36AL ribosomal protein L36a-like
RPL37A ribosomal protein L37a
RPS11 ribosomal protein S11
RPS27L ribosomal protein S27-like
RPS4Y1 ribosomal protein S4, Y-linked 1
SAR1A secretion associated, Ras related GTPase 1A
SFPQ splicing factor proline/glutamine-rich
SLC25A46 solute carrier family 25, member 46
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLIRP SRA stem-loop interacting RNA binding protein
SPATA20 spermatogenesis associated 20
SPDEF SAM pointed domain containing ETS transcription factor
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TBL1X transducin (beta)-like 1X-linked
TBP TATA box binding protein
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFAM transcription factor A, mitochondrial
TFB2M transcription factor B2, mitochondrial
TFF1 trefoil factor 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TRIM16 tripartite motif containing 16
TRIM37 tripartite motif containing 37
TSKU tsukushi, small leucine rich proteoglycan
TSPAN13 tetraspanin 13
TSPYL5 TSPY-like 5
TUBD1 tubulin, delta 1
TXLNA taxilin alpha
UBE2S ubiquitin-conjugating enzyme E2S
UBE3C ubiquitin protein ligase E3C
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UGDH UDP-glucose 6-dehydrogenase
USP22 ubiquitin specific peptidase 22
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
WSB2 WD repeat and SOCS box containing 2
XBP1 X-box binding protein 1
XPO1 exportin 1
ZMPSTE24 zinc metallopeptidase STE24
ZMYM2 zinc finger, MYM-type 2