BRD-K53780220_N-((1H-benzo[d]imidazol-2-yl)methyl)-2-morpholino-9-(thiophen-3-yl)-9H-purin-6-amine_HT29_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

128 genes differentially expressed following the BRD-K53780220_N-((1H-benzo[d]imidazol-2-yl)methyl)-2-morpholino-9-(thiophen-3-yl)-9H-purin-6-amine_HT29_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTA1 actin, alpha 1, skeletal muscle
ADD3 adducin 3 (gamma)
AEBP1 AE binding protein 1
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
AOX1 aldehyde oxidase 1
ASPN asporin
ATF3 activating transcription factor 3
CD38 CD38 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CHGB chromogranin B
COL18A1 collagen, type XVIII, alpha 1
CRIP2 cysteine-rich protein 2
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT4 DNA-damage-inducible transcript 4
DNAJC10 DnaJ (Hsp40) homolog, subfamily C, member 10
DSP desmoplakin
EGR1 early growth response 1
EPCAM epithelial cell adhesion molecule
EPHX2 epoxide hydrolase 2, cytoplasmic
F13A1 coagulation factor XIII, A1 polypeptide
GADD45B growth arrest and DNA-damage-inducible, beta
GSTA1 glutathione S-transferase alpha 1
HES1 hes family bHLH transcription factor 1
HIST1H2BD histone cluster 1, H2bd
IER3 immediate early response 3
IFITM1 interferon induced transmembrane protein 1
IFITM3 interferon induced transmembrane protein 3
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
LEF1 lymphoid enhancer-binding factor 1
MME membrane metallo-endopeptidase
MMP9 matrix metallopeptidase 9
MYH2 myosin, heavy chain 2, skeletal muscle, adult
MYL6B myosin, light chain 6B, alkali, smooth muscle and non-muscle
MYOT myotilin
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
OLFM4 olfactomedin 4
PDLIM1 PDZ and LIM domain 1
PFKM phosphofructokinase, muscle
PLAT plasminogen activator, tissue
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
S100A14 S100 calcium binding protein A14
SH3YL1 SH3 and SYLF domain containing 1
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SPINT2 serine peptidase inhibitor, Kunitz type, 2
TGFA transforming growth factor, alpha
THY1 Thy-1 cell surface antigen
TIMP3 TIMP metallopeptidase inhibitor 3
TNNC1 troponin C type 1 (slow)
TNNT1 troponin T type 1 (skeletal, slow)
TPD52L1 tumor protein D52-like 1
TSPAN7 tetraspanin 7
VARS valyl-tRNA synthetase
VIM vimentin
WASF1 WAS protein family, member 1

decreased expression

Symbol Name
ACBD3 acyl-CoA binding domain containing 3
ADNP activity-dependent neuroprotector homeobox
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP9A ATPase, class II, type 9A
AURKA aurora kinase A
AURKB aurora kinase B
AUTS2 autism susceptibility candidate 2
C14ORF169 chromosome 14 open reading frame 169
CANT1 calcium activated nucleotidase 1
CCNA2 cyclin A2
CCNF cyclin F
CDC25A cell division cycle 25A
CDC25B cell division cycle 25B
CDC6 cell division cycle 6
CDK7 cyclin-dependent kinase 7
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL14 chemokine (C-X-C motif) ligand 14
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
GABPB1 GA binding protein transcription factor, beta subunit 1
GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
GRWD1 glutamate-rich WD repeat containing 1
GSPT2 G1 to S phase transition 2
HMOX1 heme oxygenase 1
HNMT histamine N-methyltransferase
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
HSPB8 heat shock 22kDa protein 8
IDI1 isopentenyl-diphosphate delta isomerase 1
JMJD6 jumonji domain containing 6
MCM10 minichromosome maintenance complex component 10
MED13 mediator complex subunit 13
MGLL monoglyceride lipase
MLPH melanophilin
NAV2 neuron navigator 2
NET1 neuroepithelial cell transforming 1
NOTCH2NL notch 2 N-terminal like
NRIP1 nuclear receptor interacting protein 1
NUP50 nucleoporin 50kDa
NXT1 nuclear transport factor 2-like export factor 1
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PPARG peroxisome proliferator-activated receptor gamma
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PPIF peptidylprolyl isomerase F
RBP4 retinol binding protein 4, plasma
RGS2 regulator of G-protein signaling 2
RNMT RNA (guanine-7-) methyltransferase
RPL27A ribosomal protein L27a
RPP38 ribonuclease P/MRP 38kDa subunit
RPS11 ribosomal protein S11
RYBP RING1 and YY1 binding protein
SCGB2A2 secretoglobin, family 2A, member 2
SPRY2 sprouty homolog 2 (Drosophila)
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC2 transforming, acidic coiled-coil containing protein 2
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TGFBR3 transforming growth factor, beta receptor III
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TMEM2 transmembrane protein 2
TNPO1 transportin 1
TXLNA taxilin alpha
WEE1 WEE1 G2 checkpoint kinase
WSB1 WD repeat and SOCS box containing 1
XBP1 X-box binding protein 1
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
ZBED5 zinc finger, BED-type containing 5
ZMIZ1 zinc finger, MIZ-type containing 1