BRD-K53780220_N-((1H-benzo[d]imidazol-2-yl)methyl)-2-morpholino-9-(thiophen-3-yl)-9H-purin-6-amine_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

234 genes differentially expressed following the BRD-K53780220_N-((1H-benzo[d]imidazol-2-yl)methyl)-2-morpholino-9-(thiophen-3-yl)-9H-purin-6-amine_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADD3 adducin 3 (gamma)
AEBP1 AE binding protein 1
ALDOB aldolase B, fructose-bisphosphate
ALOX5 arachidonate 5-lipoxygenase
ANXA1 annexin A1
AP3S1 adaptor-related protein complex 3, sigma 1 subunit
AQP9 aquaporin 9
ASNS asparagine synthetase (glutamine-hydrolyzing)
BLNK B-cell linker
BSG basigin (Ok blood group)
CAV1 caveolin 1, caveolae protein, 22kDa
CCND2 cyclin D2
CD163 CD163 molecule
CD1E CD1e molecule
CD24 CD24 molecule
CECR1 cat eye syndrome chromosome region, candidate 1
CFB complement factor B
CFD complement factor D (adipsin)
CFH complement factor H
CTSB cathepsin B
CXCL2 chemokine (C-X-C motif) ligand 2
CYBB cytochrome b-245, beta polypeptide
DCN decorin
DDIT4 DNA-damage-inducible transcript 4
DHCR24 24-dehydrocholesterol reductase
DPYD dihydropyrimidine dehydrogenase
DUSP1 dual specificity phosphatase 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGR1 early growth response 1
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EIF5A eukaryotic translation initiation factor 5A
EMP1 epithelial membrane protein 1
F11R F11 receptor
F3 coagulation factor III (thromboplastin, tissue factor)
FPR1 formyl peptide receptor 1
GADD45B growth arrest and DNA-damage-inducible, beta
GLUL glutamate-ammonia ligase
GPM6A glycoprotein M6A
GPM6B glycoprotein M6B
GUK1 guanylate kinase 1
HES1 hes family bHLH transcription factor 1
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HIST1H2BD histone cluster 1, H2bd
HP haptoglobin
HRSP12 heat-responsive protein 12
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IFITM1 interferon induced transmembrane protein 1
IFITM3 interferon induced transmembrane protein 3
ITM2A integral membrane protein 2A
KIAA0226L KIAA0226-like
KNG1 kininogen 1
MAN1A1 mannosidase, alpha, class 1A, member 1
MARCO macrophage receptor with collagenous structure
MME membrane metallo-endopeptidase
MOCS2 molybdenum cofactor synthesis 2
MOXD1 monooxygenase, DBH-like 1
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1X metallothionein 1X
NEBL nebulette
NMRK1 nicotinamide riboside kinase 1
NMU neuromedin U
PLAU plasminogen activator, urokinase
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
REEP5 receptor accessory protein 5
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SORD sorbitol dehydrogenase
STC1 stanniocalcin 1
SULF1 sulfatase 1
TF transferrin
THBS2 thrombospondin 2
TIMP1 TIMP metallopeptidase inhibitor 1
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM176B transmembrane protein 176B
TNNC1 troponin C type 1 (slow)
TXNIP thioredoxin interacting protein
VTCN1 V-set domain containing T cell activation inhibitor 1
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon

decreased expression

Symbol Name
ABLIM1 actin binding LIM protein 1
ACBD3 acyl-CoA binding domain containing 3
ADNP activity-dependent neuroprotector homeobox
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AMD1 adenosylmethionine decarboxylase 1
ARID4B AT rich interactive domain 4B (RBP1-like)
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ATMIN ATM interactor
AURKA aurora kinase A
BAG3 BCL2-associated athanogene 3
BLCAP bladder cancer associated protein
BRPF1 bromodomain and PHD finger containing, 1
C14ORF169 chromosome 14 open reading frame 169
CANT1 calcium activated nucleotidase 1
CCNE1 cyclin E1
CCNF cyclin F
CDC25A cell division cycle 25A
CDCA4 cell division cycle associated 4
CDK13 cyclin-dependent kinase 13
CDK7 cyclin-dependent kinase 7
CDR2 cerebellar degeneration-related protein 2, 62kDa
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta
CENPF centromere protein F, 350/400kDa
CHERP calcium homeostasis endoplasmic reticulum protein
CHSY1 chondroitin sulfate synthase 1
CKS2 CDC28 protein kinase regulatory subunit 2
COA1 cytochrome c oxidase assembly factor 1 homolog (S. cerevisiae)
COIL coilin
CSE1L CSE1 chromosome segregation 1-like (yeast)
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DDX28 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28
DFNA5 deafness, autosomal dominant 5
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP14 dual specificity phosphatase 14
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
FAM208B family with sequence similarity 208, member B
FASTKD5 FAST kinase domains 5
FEM1B fem-1 homolog b (C. elegans)
FOSL1 FOS-like antigen 1
FOXJ3 forkhead box J3
FOXN3 forkhead box N3
FOXO1 forkhead box O1
FOXO3 forkhead box O3
GABPB1 GA binding protein transcription factor, beta subunit 1
GGNBP2 gametogenetin binding protein 2
GPATCH8 G patch domain containing 8
GREM1 gremlin 1, DAN family BMP antagonist
GRWD1 glutamate-rich WD repeat containing 1
GSPT2 G1 to S phase transition 2
GTF2E1 general transcription factor IIE, polypeptide 1, alpha 56kDa
H2AFX H2A histone family, member X
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HOPX HOP homeobox
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
HSPB8 heat shock 22kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IPO7 importin 7
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
IST1 increased sodium tolerance 1 homolog (yeast)
JMJD6 jumonji domain containing 6
KAT6A K(lysine) acetyltransferase 6A
KDM3A lysine (K)-specific demethylase 3A
KDM5B lysine (K)-specific demethylase 5B
KEAP1 kelch-like ECH-associated protein 1
KIAA0125 KIAA0125
KIAA0232 KIAA0232
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LAT2 linker for activation of T cells family, member 2
LCMT2 leucine carboxyl methyltransferase 2
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP3K4 mitogen-activated protein kinase kinase kinase 4
MAPK6 mitogen-activated protein kinase 6
MARCKS myristoylated alanine-rich protein kinase C substrate
MED17 mediator complex subunit 17
MFSD5 major facilitator superfamily domain containing 5
MSH6 mutS homolog 6
NET1 neuroepithelial cell transforming 1
NFE2L2 nuclear factor, erythroid 2-like 2
NFYA nuclear transcription factor Y, alpha
NGDN neuroguidin, EIF4E binding protein
NKX3-1 NK3 homeobox 1
NOL11 nucleolar protein 11
NRIP1 nuclear receptor interacting protein 1
NUP153 nucleoporin 153kDa
NUP62 nucleoporin 62kDa
NUP98 nucleoporin 98kDa
PALB2 partner and localizer of BRCA2
PLAGL2 pleiomorphic adenoma gene-like 2
POU2AF1 POU class 2 associating factor 1
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1
PROM1 prominin 1
PRPF4B pre-mRNA processing factor 4B
PTRH2 peptidyl-tRNA hydrolase 2
RANBP2 RAN binding protein 2
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RBM12 RNA binding motif protein 12
RBM15 RNA binding motif protein 15
RLF rearranged L-myc fusion
RNF111 ring finger protein 111
RNF4 ring finger protein 4
RNMT RNA (guanine-7-) methyltransferase
SACS sacsin molecular chaperone
SCAF8 SR-related CTD-associated factor 8
SEC24B SEC24 family member B
SIRT1 sirtuin 1
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SMAD3 SMAD family member 3
SMAD7 SMAD family member 7
SMG8 SMG8 nonsense mediated mRNA decay factor
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
STK17A serine/threonine kinase 17a
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TAF5 TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa
TBC1D4 TBC1 domain family, member 4
TEX10 testis expressed 10
TFB2M transcription factor B2, mitochondrial
TGFBR3 transforming growth factor, beta receptor III
THUMPD1 THUMP domain containing 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLE4 transducin-like enhancer of split 4
TMEM11 transmembrane protein 11
TNPO1 transportin 1
TSC22D2 TSC22 domain family, member 2
TSPYL5 TSPY-like 5
TUBB2A tubulin, beta 2A class IIa
TXLNA taxilin alpha
WEE1 WEE1 G2 checkpoint kinase
WIPF2 WAS/WASL interacting protein family, member 2
XBP1 X-box binding protein 1
YTHDF2 YTH N(6)-methyladenosine RNA binding protein 2
YTHDF3 YTH N(6)-methyladenosine RNA binding protein 3
ZBED5 zinc finger, BED-type containing 5
ZCCHC2 zinc finger, CCHC domain containing 2
ZNF146 zinc finger protein 146
ZNF318 zinc finger protein 318