BRD-K53780220_N-((1H-benzo[d]imidazol-2-yl)methyl)-2-morpholino-9-(thiophen-3-yl)-9H-purin-6-amine_HCC515_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

252 genes differentially expressed following the BRD-K53780220_N-((1H-benzo[d]imidazol-2-yl)methyl)-2-morpholino-9-(thiophen-3-yl)-9H-purin-6-amine_HCC515_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADD3 adducin 3 (gamma)
ALOX5 arachidonate 5-lipoxygenase
ATF3 activating transcription factor 3
BSG basigin (Ok blood group)
CA1 carbonic anhydrase I
CA2 carbonic anhydrase II
CD177 CD177 molecule
CD36 CD36 molecule (thrombospondin receptor)
CD9 CD9 molecule
CECR1 cat eye syndrome chromosome region, candidate 1
CLC Charcot-Leyden crystal galectin
COL1A2 collagen, type I, alpha 2
CRABP2 cellular retinoic acid binding protein 2
CXCL2 chemokine (C-X-C motif) ligand 2
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGR1 early growth response 1
EIF1 eukaryotic translation initiation factor 1
EIF5A eukaryotic translation initiation factor 5A
FBN2 fibrillin 2
FGL2 fibrinogen-like 2
FOS FBJ murine osteosarcoma viral oncogene homolog
FST follistatin
GADD45B growth arrest and DNA-damage-inducible, beta
GAS6 growth arrest-specific 6
GPX3 glutathione peroxidase 3
GRN granulin
GULP1 GULP, engulfment adaptor PTB domain containing 1
H1FX H1 histone family, member X
HES1 hes family bHLH transcription factor 1
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BG histone cluster 1, H2bg
HIST2H2BE histone cluster 2, H2be
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGN4 high mobility group nucleosomal binding domain 4
HTRA1 HtrA serine peptidase 1
IFT57 intraflagellar transport 57
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
ISG15 ISG15 ubiquitin-like modifier
ITM2C integral membrane protein 2C
JAG1 jagged 1
KAT2B K(lysine) acetyltransferase 2B
KIAA0226L KIAA0226-like
MAOA monoamine oxidase A
MMP9 matrix metallopeptidase 9
MXI1 MAX interactor 1, dimerization protein
NRP1 neuropilin 1
NUPR1 nuclear protein, transcriptional regulator, 1
OLFM4 olfactomedin 4
PFKM phosphofructokinase, muscle
PLN phospholamban
POSTN periostin, osteoblast specific factor
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PTP4A3 protein tyrosine phosphatase type IVA, member 3
RGS5 regulator of G-protein signaling 5
RNASE6 ribonuclease, RNase A family, k6
SDC1 syndecan 1
SEPT2 septin 2
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3
TPM2 tropomyosin 2 (beta)
TUSC3 tumor suppressor candidate 3
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VEGFA vascular endothelial growth factor A

decreased expression

Symbol Name
ACBD3 acyl-CoA binding domain containing 3
ADNP activity-dependent neuroprotector homeobox
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AFF1 AF4/FMR2 family, member 1
AGR2 anterior gradient 2
AHR aryl hydrocarbon receptor
ALKBH1 alkB, alkylation repair homolog 1 (E. coli)
ANKRD17 ankyrin repeat domain 17
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ARID4B AT rich interactive domain 4B (RBP1-like)
ASXL2 additional sex combs like transcriptional regulator 2
ATF5 activating transcription factor 5
ATF7IP activating transcription factor 7 interacting protein
AURKA aurora kinase A
BAG3 BCL2-associated athanogene 3
BAG5 BCL2-associated athanogene 5
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BCL10 B-cell CLL/lymphoma 10
BLMH bleomycin hydrolase
BRPF1 bromodomain and PHD finger containing, 1
C14ORF169 chromosome 14 open reading frame 169
CANT1 calcium activated nucleotidase 1
CCNA2 cyclin A2
CCNF cyclin F
CDC25A cell division cycle 25A
CDCA4 cell division cycle associated 4
CDK7 cyclin-dependent kinase 7
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CDR2 cerebellar degeneration-related protein 2, 62kDa
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta
CEP76 centrosomal protein 76kDa
CHERP calcium homeostasis endoplasmic reticulum protein
CHSY1 chondroitin sulfate synthase 1
CNOT4 CCR4-NOT transcription complex, subunit 4
COIL coilin
DBF4 DBF4 zinc finger
DDX28 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28
DEFB1 defensin, beta 1
DICER1 dicer 1, ribonuclease type III
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP10 dual specificity phosphatase 10
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
ELF1 E74-like factor 1 (ets domain transcription factor)
FADD Fas (TNFRSF6)-associated via death domain
FAM222B family with sequence similarity 222, member B
FASTKD5 FAST kinase domains 5
FEM1B fem-1 homolog b (C. elegans)
FOSL1 FOS-like antigen 1
GAS1 growth arrest-specific 1
GLUL glutamate-ammonia ligase
GOSR1 golgi SNAP receptor complex member 1
GPATCH8 G patch domain containing 8
GRWD1 glutamate-rich WD repeat containing 1
GSPT2 G1 to S phase transition 2
GTF2E1 general transcription factor IIE, polypeptide 1, alpha 56kDa
HOMER1 homer scaffolding protein 1
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IRS2 insulin receptor substrate 2
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
IST1 increased sodium tolerance 1 homolog (yeast)
JADE2 jade family PHD finger 2
JARID2 jumonji, AT rich interactive domain 2
JMJD1C jumonji domain containing 1C
JMJD6 jumonji domain containing 6
KDM2A lysine (K)-specific demethylase 2A
KDM5B lysine (K)-specific demethylase 5B
KEAP1 kelch-like ECH-associated protein 1
KIF14 kinesin family member 14
KIF2C kinesin family member 2C
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KYNU kynureninase
LCMT2 leucine carboxyl methyltransferase 2
LDHB lactate dehydrogenase B
LRIF1 ligand dependent nuclear receptor interacting factor 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP3K4 mitogen-activated protein kinase kinase kinase 4
MAPK6 mitogen-activated protein kinase 6
MCL1 myeloid cell leukemia 1
MED1 mediator complex subunit 1
MED13 mediator complex subunit 13
MED17 mediator complex subunit 17
MEPCE methylphosphate capping enzyme
MFAP1 microfibrillar-associated protein 1
MGLL monoglyceride lipase
MRFAP1L1 Morf4 family associated protein 1-like 1
MRPS30 mitochondrial ribosomal protein S30
MSH6 mutS homolog 6
MTF2 metal response element binding transcription factor 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NET1 neuroepithelial cell transforming 1
NFE2L2 nuclear factor, erythroid 2-like 2
NFIB nuclear factor I/B
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NKX3-1 NK3 homeobox 1
NOL11 nucleolar protein 11
NPAT nuclear protein, ataxia-telangiectasia locus
NRBF2 nuclear receptor binding factor 2
NRIP1 nuclear receptor interacting protein 1
NUP153 nucleoporin 153kDa
NUP62 nucleoporin 62kDa
NUP98 nucleoporin 98kDa
PFKP phosphofructokinase, platelet
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIK3R4 phosphoinositide-3-kinase, regulatory subunit 4
PLAGL2 pleiomorphic adenoma gene-like 2
PNMA1 paraneoplastic Ma antigen 1
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PRRC2C proline-rich coiled-coil 2C
RANBP2 RAN binding protein 2
RANBP6 RAN binding protein 6
RBM15 RNA binding motif protein 15
REST RE1-silencing transcription factor
RGS2 regulator of G-protein signaling 2
RLF rearranged L-myc fusion
RNF111 ring finger protein 111
RNF4 ring finger protein 4
RNF6 ring finger protein (C3H2C3 type) 6
RNMT RNA (guanine-7-) methyltransferase
RPL36AL ribosomal protein L36a-like
RPP38 ribonuclease P/MRP 38kDa subunit
RPS11 ribosomal protein S11
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SACS sacsin molecular chaperone
SCAF8 SR-related CTD-associated factor 8
SCYL3 SCY1-like 3 (S. cerevisiae)
SEC24A SEC24 family member A
SEC24B SEC24 family member B
SECISBP2L SECIS binding protein 2-like
SETD1B SET domain containing 1B
SETD5 SET domain containing 5
SIRT1 sirtuin 1
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC25A44 solute carrier family 25, member 44
SLC43A3 solute carrier family 43, member 3
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SMAD3 SMAD family member 3
SMG8 SMG8 nonsense mediated mRNA decay factor
SNRK SNF related kinase
SON SON DNA binding protein
SOX9 SRY (sex determining region Y)-box 9
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SUV420H1 suppressor of variegation 4-20 homolog 1 (Drosophila)
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TEFM transcription elongation factor, mitochondrial
TFF1 trefoil factor 1
TGFBR3 transforming growth factor, beta receptor III
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TM4SF1 transmembrane 4 L six family member 1
TMEM11 transmembrane protein 11
TMEM97 transmembrane protein 97
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNPO1 transportin 1
TOB2 transducer of ERBB2, 2
TP53BP2 tumor protein p53 binding protein 2
TRIM32 tripartite motif containing 32
TSC22D2 TSC22 domain family, member 2
USP6NL USP6 N-terminal like
UTP3 UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae)
WEE1 WEE1 G2 checkpoint kinase
WIPF2 WAS/WASL interacting protein family, member 2
XBP1 X-box binding protein 1
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
YTHDF3 YTH N(6)-methyladenosine RNA binding protein 3
ZBTB11 zinc finger and BTB domain containing 11
ZCCHC2 zinc finger, CCHC domain containing 2
ZCCHC8 zinc finger, CCHC domain containing 8
ZNF189 zinc finger protein 189
ZNF200 zinc finger protein 200
ZNF217 zinc finger protein 217
ZNF267 zinc finger protein 267
ZNF330 zinc finger protein 330
ZNF443 zinc finger protein 443