BRD-K53780220_N-((1H-benzo[d]imidazol-2-yl)methyl)-2-morpholino-9-(thiophen-3-yl)-9H-purin-6-amine_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

307 genes differentially expressed following the BRD-K53780220_N-((1H-benzo[d]imidazol-2-yl)methyl)-2-morpholino-9-(thiophen-3-yl)-9H-purin-6-amine_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ADAM9 ADAM metallopeptidase domain 9
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ALCAM activated leukocyte cell adhesion molecule
ANXA6 annexin A6
AP2B1 adaptor-related protein complex 2, beta 1 subunit
AQP9 aquaporin 9
AREG amphiregulin
ATF3 activating transcription factor 3
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BAG6 BCL2-associated athanogene 6
BHLHE40 basic helix-loop-helix family, member e40
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
C3 complement component 3
CA2 carbonic anhydrase II
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CASP7 caspase 7, apoptosis-related cysteine peptidase
CAV1 caveolin 1, caveolae protein, 22kDa
CCDC85B coiled-coil domain containing 85B
CCL2 chemokine (C-C motif) ligand 2
CCL4 chemokine (C-C motif) ligand 4
CD24 CD24 molecule
CD69 CD69 molecule
CD99 CD99 molecule
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CLU clusterin
CPM carboxypeptidase M
CTSB cathepsin B
CTSL cathepsin L
CTSZ cathepsin Z
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT4 DNA-damage-inducible transcript 4
DPYD dihydropyrimidine dehydrogenase
DUSP1 dual specificity phosphatase 1
DUSP6 dual specificity phosphatase 6
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
EID1 EP300 interacting inhibitor of differentiation 1
EIF5A eukaryotic translation initiation factor 5A
EPAS1 endothelial PAS domain protein 1
FLNA filamin A, alpha
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
G0S2 G0/G1 switch 2
GADD45B growth arrest and DNA-damage-inducible, beta
GANAB glucosidase, alpha; neutral AB
GNB2 guanine nucleotide binding protein (G protein), beta polypeptide 2
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GPM6A glycoprotein M6A
GRB14 growth factor receptor-bound protein 14
GSN gelsolin
H1FX H1 histone family, member X
HBB hemoglobin, beta
HES1 hes family bHLH transcription factor 1
HIST1H1C histone cluster 1, H1c
HLA-B major histocompatibility complex, class I, B
HOXA5 homeobox A5
ICAM3 intercellular adhesion molecule 3
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IER3 immediate early response 3
IFITM1 interferon induced transmembrane protein 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP3 insulin-like growth factor binding protein 3
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KIAA0226L KIAA0226-like
KLF10 Kruppel-like factor 10
KLF2 Kruppel-like factor 2
KRT23 keratin 23, type I
KRT8 keratin 8, type II
LDOC1 leucine zipper, down-regulated in cancer 1
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LITAF lipopolysaccharide-induced TNF factor
LTB lymphotoxin beta (TNF superfamily, member 3)
LTBP3 latent transforming growth factor beta binding protein 3
LYN LYN proto-oncogene, Src family tyrosine kinase
METTL7A methyltransferase like 7A
MME membrane metallo-endopeptidase
MOXD1 monooxygenase, DBH-like 1
MXI1 MAX interactor 1, dimerization protein
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFIL3 nuclear factor, interleukin 3 regulated
NPY1R neuropeptide Y receptor Y1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NTS neurotensin
NUPR1 nuclear protein, transcriptional regulator, 1
ORM1 orosomucoid 1
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDIA3 protein disulfide isomerase family A, member 3
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLD3 phospholipase D family, member 3
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PSAP prosaposin
PSENEN presenilin enhancer gamma secretase subunit
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RGS2 regulator of G-protein signaling 2
SAT1 spermidine/spermine N1-acetyltransferase 1
SELENBP1 selenium binding protein 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SGK1 serum/glucocorticoid regulated kinase 1
SOX4 SRY (sex determining region Y)-box 4
SPON2 spondin 2, extracellular matrix protein
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3
TDO2 tryptophan 2,3-dioxygenase
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMSB15A thymosin beta 15a
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPD52 tumor protein D52
TRIB1 tribbles pseudokinase 1
TSC22D1 TSC22 domain family, member 1
TSC22D3 TSC22 domain family, member 3
TUBA1A tubulin, alpha 1a
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VTCN1 V-set domain containing T cell activation inhibitor 1
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ACBD3 acyl-CoA binding domain containing 3
ADNP activity-dependent neuroprotector homeobox
AKAP8 A kinase (PRKA) anchor protein 8
ALKBH1 alkB, alkylation repair homolog 1 (E. coli)
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ARID4B AT rich interactive domain 4B (RBP1-like)
ASXL2 additional sex combs like transcriptional regulator 2
AURKA aurora kinase A
BAG3 BCL2-associated athanogene 3
BAG5 BCL2-associated athanogene 5
BLCAP bladder cancer associated protein
BRPF1 bromodomain and PHD finger containing, 1
CANT1 calcium activated nucleotidase 1
CCNA2 cyclin A2
CCNF cyclin F
CD58 CD58 molecule
CDC25A cell division cycle 25A
CDCA4 cell division cycle associated 4
CDK7 cyclin-dependent kinase 7
CDK8 cyclin-dependent kinase 8
CEP350 centrosomal protein 350kDa
CHD1 chromodomain helicase DNA binding protein 1
CHERP calcium homeostasis endoplasmic reticulum protein
CIAPIN1 cytokine induced apoptosis inhibitor 1
CNOT4 CCR4-NOT transcription complex, subunit 4
COIL coilin
CRNKL1 crooked neck pre-mRNA splicing factor 1
CRY1 cryptochrome circadian clock 1
CSTF1 cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa
DBF4 DBF4 zinc finger
DCLK1 doublecortin-like kinase 1
DCLRE1C DNA cross-link repair 1C
DDX47 DEAD (Asp-Glu-Ala-Asp) box polypeptide 47
DKFZP586I1420 uncharacterized protein DKFZp586I1420
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2
DUSP4 dual specificity phosphatase 4
DUSP7 dual specificity phosphatase 7
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
E2F6 E2F transcription factor 6
EED embryonic ectoderm development
EIF4ENIF1 eukaryotic translation initiation factor 4E nuclear import factor 1
ELL2 elongation factor, RNA polymerase II, 2
ESF1 ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae)
EXOSC4 exosome component 4
FAM222B family with sequence similarity 222, member B
FAM57A family with sequence similarity 57, member A
FASTKD1 FAST kinase domains 1
FASTKD5 FAST kinase domains 5
FBXO11 F-box protein 11
FBXO28 F-box protein 28
GOLGA8A golgin A8 family, member A
GOSR1 golgi SNAP receptor complex member 1
GRWD1 glutamate-rich WD repeat containing 1
GTF2B general transcription factor IIB
HIC2 hypermethylated in cancer 2
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOMER1 homer scaffolding protein 1
IDI1 isopentenyl-diphosphate delta isomerase 1
ING3 inhibitor of growth family, member 3
INPP1 inositol polyphosphate-1-phosphatase
IPO7 importin 7
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
JADE1 jade family PHD finger 1
JMJD6 jumonji domain containing 6
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KEAP1 kelch-like ECH-associated protein 1
KIAA0907 KIAA0907
KLHL9 kelch-like family member 9
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRT6B keratin 6B, type II
KYNU kynureninase
LIPT1 lipoyltransferase 1
LTN1 listerin E3 ubiquitin protein ligase 1
MAK16 MAK16 homolog (S. cerevisiae)
MAP3K4 mitogen-activated protein kinase kinase kinase 4
MAPK6 mitogen-activated protein kinase 6
MED13 mediator complex subunit 13
METTL13 methyltransferase like 13
MID1 midline 1
MSANTD2 Myb/SANT-like DNA-binding domain containing 2
MSH6 mutS homolog 6
MSMO1 methylsterol monooxygenase 1
MTCL1 microtubule crosslinking factor 1
MTF2 metal response element binding transcription factor 2
MTPAP mitochondrial poly(A) polymerase
N4BP2L2 NEDD4 binding protein 2-like 2
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NET1 neuroepithelial cell transforming 1
NGDN neuroguidin, EIF4E binding protein
NOC3L nucleolar complex associated 3 homolog (S. cerevisiae)
NOL11 nucleolar protein 11
NOP16 NOP16 nucleolar protein
NRIP1 nuclear receptor interacting protein 1
NRN1 neuritin 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NUP50 nucleoporin 50kDa
NUP62 nucleoporin 62kDa
NXT1 nuclear transport factor 2-like export factor 1
PANK3 pantothenate kinase 3
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PCF11 PCF11 cleavage and polyadenylation factor subunit
PDGFA platelet-derived growth factor alpha polypeptide
PELO pelota homolog (Drosophila)
PMS1 PMS1 postmeiotic segregation increased 1 (S. cerevisiae)
PNISR PNN-interacting serine/arginine-rich protein
PNN pinin, desmosome associated protein
POLR1D polymerase (RNA) I polypeptide D, 16kDa
PPIF peptidylprolyl isomerase F
PRPF4 pre-mRNA processing factor 4
PRRC2C proline-rich coiled-coil 2C
PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12
PTHLH parathyroid hormone-like hormone
PTRH2 peptidyl-tRNA hydrolase 2
RAB3GAP2 RAB3 GTPase activating protein subunit 2 (non-catalytic)
RAE1 ribonucleic acid export 1
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RBM15 RNA binding motif protein 15
RCHY1 ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase
RNF111 ring finger protein 111
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RNF219 ring finger protein 219
RNF6 ring finger protein (C3H2C3 type) 6
RNMT RNA (guanine-7-) methyltransferase
RPP38 ribonuclease P/MRP 38kDa subunit
RPS11 ribosomal protein S11
RREB1 ras responsive element binding protein 1
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast)
SEC24B SEC24 family member B
SETD5 SET domain containing 5
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SMG8 SMG8 nonsense mediated mRNA decay factor
SNRPG small nuclear ribonucleoprotein polypeptide G
SNX11 sorting nexin 11
SS18L2 synovial sarcoma translocation gene on chromosome 18-like 2
STAM signal transducing adaptor molecule (SH3 domain and ITAM motif) 1
TAF9 TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa
TBC1D4 TBC1 domain family, member 4
TBP TATA box binding protein
TBPL1 TBP-like 1
TEFM transcription elongation factor, mitochondrial
TFB2M transcription factor B2, mitochondrial
TIMM17A translocase of inner mitochondrial membrane 17 homolog A (yeast)
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM97 transmembrane protein 97
TOMM70A translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)
TSC22D2 TSC22 domain family, member 2
TUBB4B tubulin, beta 4B class IVb
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UMPS uridine monophosphate synthetase
URB2 URB2 ribosome biogenesis 2 homolog (S. cerevisiae)
USP1 ubiquitin specific peptidase 1
UTP3 UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae)
WAPAL wings apart-like homolog (Drosophila)
WEE1 WEE1 G2 checkpoint kinase
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
ZBED2 zinc finger, BED-type containing 2
ZBTB11 zinc finger and BTB domain containing 11
ZCCHC8 zinc finger, CCHC domain containing 8
ZMYM2 zinc finger, MYM-type 2
ZNF131 zinc finger protein 131
ZNF189 zinc finger protein 189
ZNF266 zinc finger protein 266