BRD-K53566850_1-(4-chlorobenzyl)-4-[4-(2-methylphenyl)-1-piperazinyl]-1H-pyrazolo[3,4-d]pyrimidine_PC3_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

46 genes differentially expressed following the BRD-K53566850_1-(4-chlorobenzyl)-4-[4-(2-methylphenyl)-1-piperazinyl]-1H-pyrazolo[3,4-d]pyrimidine_PC3_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AREG amphiregulin
CCNG2 cyclin G2
FRZB frizzled-related protein
FZD10 frizzled class receptor 10
IGFBP7 insulin-like growth factor binding protein 7
KRT14 keratin 14, type I
LDOC1 leucine zipper, down-regulated in cancer 1
MMP7 matrix metallopeptidase 7
PPAP2B phosphatidic acid phosphatase type 2B
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
TBL1X transducin (beta)-like 1X-linked
VCAM1 vascular cell adhesion molecule 1

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
APLP2 amyloid beta (A4) precursor-like protein 2
AQP3 aquaporin 3 (Gill blood group)
ARF4 ADP-ribosylation factor 4
ATP6V1A ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A
CA2 carbonic anhydrase II
CCNG1 cyclin G1
CXCL8 chemokine (C-X-C motif) ligand 8
DAPK1 death-associated protein kinase 1
DST dystonin
EMC2 ER membrane protein complex subunit 2
F3 coagulation factor III (thromboplastin, tissue factor)
GPRC5A G protein-coupled receptor, class C, group 5, member A
HMGA2 high mobility group AT-hook 2
HSPD1 heat shock 60kDa protein 1 (chaperonin)
LAMP3 lysosomal-associated membrane protein 3
MDFIC MyoD family inhibitor domain containing
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial
NMI N-myc (and STAT) interactor
PLS1 plastin 1
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
RALB v-ral simian leukemia viral oncogene homolog B
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
RPP38 ribonuclease P/MRP 38kDa subunit
S100A7 S100 calcium binding protein A7
SCP2 sterol carrier protein 2
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SRP54 signal recognition particle 54kDa
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TMED2 transmembrane emp24 domain trafficking protein 2
TPD52 tumor protein D52
UBE2A ubiquitin-conjugating enzyme E2A
ZDHHC11 zinc finger, DHHC-type containing 11