BRD-K53461563_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

118 genes differentially expressed following the BRD-K53461563_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ANXA3 annexin A3
AQP3 aquaporin 3 (Gill blood group)
ARF1 ADP-ribosylation factor 1
ATF3 activating transcription factor 3
BMP2 bone morphogenetic protein 2
C1ORF54 chromosome 1 open reading frame 54
CADM1 cell adhesion molecule 1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD9 CD9 molecule
CELF2 CUGBP, Elav-like family member 2
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHIC2 cysteine-rich hydrophobic domain 2
CNPY3 canopy FGF signaling regulator 3
CRABP1 cellular retinoic acid binding protein 1
CRABP2 cellular retinoic acid binding protein 2
CRIP2 cysteine-rich protein 2
CXCL14 chemokine (C-X-C motif) ligand 14
CYR61 cysteine-rich, angiogenic inducer, 61
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGR1 early growth response 1
EIF5A eukaryotic translation initiation factor 5A
EMP1 epithelial membrane protein 1
ERLIN2 ER lipid raft associated 2
F2RL1 coagulation factor II (thrombin) receptor-like 1
FOSL1 FOS-like antigen 1
FOSL2 FOS-like antigen 2
GEM GTP binding protein overexpressed in skeletal muscle
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IGHM immunoglobulin heavy constant mu
KIAA0226L KIAA0226-like
KLF6 Kruppel-like factor 6
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP2K3 mitogen-activated protein kinase kinase 3
MCL1 myeloid cell leukemia 1
MME membrane metallo-endopeptidase
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1M metallothionein 1M
MT1X metallothionein 1X
NPIPB3 nuclear pore complex interacting protein family, member B3
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
PDLIM4 PDZ and LIM domain 4
POSTN periostin, osteoblast specific factor
RGCC regulator of cell cycle
RGS10 regulator of G-protein signaling 10
RPL10 ribosomal protein L10
SELENBP1 selenium binding protein 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SH3GLB1 SH3-domain GRB2-like endophilin B1
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3
SLC38A1 solute carrier family 38, member 1
SMAD3 SMAD family member 3
SOD2 superoxide dismutase 2, mitochondrial
THBD thrombomodulin
TMEM158 transmembrane protein 158 (gene/pseudogene)
USP6NL USP6 N-terminal like
VEGFA vascular endothelial growth factor A
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ADARB1 adenosine deaminase, RNA-specific, B1
AGR2 anterior gradient 2
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
CALML4 calmodulin-like 4
CAST calpastatin
CCNA1 cyclin A1
CCNF cyclin F
CIAPIN1 cytokine induced apoptosis inhibitor 1
CPA3 carboxypeptidase A3 (mast cell)
CTSZ cathepsin Z
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLK1 delta-like 1 homolog (Drosophila)
DMD dystrophin
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
F13A1 coagulation factor XIII, A1 polypeptide
FGFR3 fibroblast growth factor receptor 3
FHL1 four and a half LIM domains 1
GALNT11 polypeptide N-acetylgalactosaminyltransferase 11
GAS2L1 growth arrest-specific 2 like 1
GRIA2 glutamate receptor, ionotropic, AMPA 2
GUCY1B3 guanylate cyclase 1, soluble, beta 3
HEXIM1 hexamethylene bis-acetamide inducible 1
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IL17RB interleukin 17 receptor B
ITM2A integral membrane protein 2A
KAZN kazrin, periplakin interacting protein
LGALS1 lectin, galactoside-binding, soluble, 1
LTF lactotransferrin
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAP7 microtubule-associated protein 7
MSH6 mutS homolog 6
MUC5B mucin 5B, oligomeric mucus/gel-forming
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing
NME4 NME/NM23 nucleoside diphosphate kinase 4
NMT1 N-myristoyltransferase 1
PDZK1 PDZ domain containing 1
PLK1 polo-like kinase 1
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H
PTP4A2 protein tyrosine phosphatase type IVA, member 2
RAB26 RAB26, member RAS oncogene family
RHOBTB3 Rho-related BTB domain containing 3
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SRC SRC proto-oncogene, non-receptor tyrosine kinase
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TNIK TRAF2 and NCK interacting kinase
TPSAB1 tryptase alpha/beta 1