BRD-K53423944_6-[4-(3-chlorophenyl)piperazin-1-yl]-3-cyclohexylpyrimidine-2,4(1H,3H)-dione_VCAP_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

49 genes differentially expressed following the BRD-K53423944_6-[4-(3-chlorophenyl)piperazin-1-yl]-3-cyclohexylpyrimidine-2,4(1H,3H)-dione_VCAP_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ACSL3 acyl-CoA synthetase long-chain family member 3
BTG2 BTG family, member 2
CD1E CD1e molecule
CD8A CD8a molecule
CELF2 CUGBP, Elav-like family member 2
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CXCL9 chemokine (C-X-C motif) ligand 9
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DCN decorin
DHCR7 7-dehydrocholesterol reductase
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
EZR ezrin
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FYB FYN binding protein
G0S2 G0/G1 switch 2
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPB8 heat shock 22kDa protein 8
IDI1 isopentenyl-diphosphate delta isomerase 1
INSIG1 insulin induced gene 1
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
LCN2 lipocalin 2
LDLR low density lipoprotein receptor
LPAR6 lysophosphatidic acid receptor 6
MMP9 matrix metallopeptidase 9
MSMO1 methylsterol monooxygenase 1
PEG3 paternally expressed 3
PLBD1 phospholipase B domain containing 1
PLEKHJ1 pleckstrin homology domain containing, family J member 1
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTPRC protein tyrosine phosphatase, receptor type, C
SQLE squalene epoxidase
TUBB2A tubulin, beta 2A class IIa

decreased expression

Symbol Name
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
AKR1C3 aldo-keto reductase family 1, member C3
CNOT4 CCR4-NOT transcription complex, subunit 4
DST dystonin
ERBB2 erb-b2 receptor tyrosine kinase 2
GRIA2 glutamate receptor, ionotropic, AMPA 2
IRS2 insulin receptor substrate 2
KRT7 keratin 7, type II
LAMA3 laminin, alpha 3
MKL2 MKL/myocardin-like 2
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PPL periplakin
SPTBN1 spectrin, beta, non-erythrocytic 1
TMEM5 transmembrane protein 5
UBE3C ubiquitin protein ligase E3C