BRD-K53423944_6-[4-(3-chlorophenyl)piperazin-1-yl]-3-cyclohexylpyrimidine-2,4(1H,3H)-dione_VCAP_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

142 genes differentially expressed following the BRD-K53423944_6-[4-(3-chlorophenyl)piperazin-1-yl]-3-cyclohexylpyrimidine-2,4(1H,3H)-dione_VCAP_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALDOC aldolase C, fructose-bisphosphate
ANXA6 annexin A6
APOD apolipoprotein D
AREG amphiregulin
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
AURKA aurora kinase A
AUTS2 autism susceptibility candidate 2
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BCL2A1 BCL2-related protein A1
CAPG capping protein (actin filament), gelsolin-like
CCNG2 cyclin G2
CD24 CD24 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CENPN centromere protein N
CLEC2B C-type lectin domain family 2, member B
CLEC3B C-type lectin domain family 3, member B
COL9A3 collagen, type IX, alpha 3
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2
DDIT4 DNA-damage-inducible transcript 4
EFHD1 EF-hand domain family, member D1
EMP2 epithelial membrane protein 2
EREG epiregulin
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FAM129A family with sequence similarity 129, member A
FERMT2 fermitin family member 2
G0S2 G0/G1 switch 2
GLA galactosidase, alpha
GPM6B glycoprotein M6B
GPR137B G protein-coupled receptor 137B
HSPA13 heat shock protein 70kDa family, member 13
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IDI1 isopentenyl-diphosphate delta isomerase 1
IL7R interleukin 7 receptor
KLHL7 kelch-like family member 7
KLRB1 killer cell lectin-like receptor subfamily B, member 1
KRT14 keratin 14, type I
KRT15 keratin 15, type I
LTF lactotransferrin
LUM lumican
MARCKSL1 MARCKS-like 1
MGLL monoglyceride lipase
NEBL nebulette
NTAN1 N-terminal asparagine amidase
OLFM4 olfactomedin 4
PCDH9 protocadherin 9
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PLK1 polo-like kinase 1
PPAP2B phosphatidic acid phosphatase type 2B
PROM1 prominin 1
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTN pleiotrophin
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RRAGC Ras-related GTP binding C
RYBP RING1 and YY1 binding protein
S100A8 S100 calcium binding protein A8
SCGB2A2 secretoglobin, family 2A, member 2
SCUBE2 signal peptide, CUB domain, EGF-like 2
SDC4 syndecan 4
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SOX4 SRY (sex determining region Y)-box 4
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
STMN1 stathmin 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TSC22D3 TSC22 domain family, member 3
TUBB2A tubulin, beta 2A class IIa
TXNIP thioredoxin interacting protein
UBE2C ubiquitin-conjugating enzyme E2C
UGDH UDP-glucose 6-dehydrogenase
VTCN1 V-set domain containing T cell activation inhibitor 1

decreased expression

Symbol Name
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ADGRE5 adhesion G protein-coupled receptor E5
AHCY adenosylhomocysteinase
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
C1RL complement component 1, r subcomponent-like
C9ORF3 chromosome 9 open reading frame 3
CBR1 carbonyl reductase 1
CCDC85B coiled-coil domain containing 85B
CD47 CD47 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CLDN10 claudin 10
COA3 cytochrome c oxidase assembly factor 3
COA4 cytochrome c oxidase assembly factor 4 homolog (S. cerevisiae)
CP ceruloplasmin (ferroxidase)
CTSE cathepsin E
DNPH1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1
EIF5A eukaryotic translation initiation factor 5A
ELOVL6 ELOVL fatty acid elongase 6
EMG1 EMG1 N1-specific pseudouridine methyltransferase
EPRS glutamyl-prolyl-tRNA synthetase
ETFB electron-transfer-flavoprotein, beta polypeptide
ETNK1 ethanolamine kinase 1
FAM216A family with sequence similarity 216, member A
FAM57A family with sequence similarity 57, member A
FOLR1 folate receptor 1 (adult)
FXYD3 FXYD domain containing ion transport regulator 3
GOLGA8A golgin A8 family, member A
HPN hepsin
HSPD1 heat shock 60kDa protein 1 (chaperonin)
IFI44L interferon-induced protein 44-like
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
IRS2 insulin receptor substrate 2
KRT13 keratin 13, type I
LAMA3 laminin, alpha 3
MGST2 microsomal glutathione S-transferase 2
MRPL12 mitochondrial ribosomal protein L12
MRPL57 mitochondrial ribosomal protein L57
MRPS16 mitochondrial ribosomal protein S16
MSLN mesothelin
MTA1 metastasis associated 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NHP2 NHP2 ribonucleoprotein
NIPSNAP1 nipsnap homolog 1 (C. elegans)
NME1 NME/NM23 nucleoside diphosphate kinase 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
PLAC8 placenta-specific 8
PON2 paraoxonase 2
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PSPH phosphoserine phosphatase
PUS7 pseudouridylate synthase 7 (putative)
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RPRD1A regulation of nuclear pre-mRNA domain containing 1A
RSL1D1 ribosomal L1 domain containing 1
SCCPDH saccharopine dehydrogenase (putative)
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SFXN1 sideroflexin 1
SPATA20 spermatogenesis associated 20
SPON1 spondin 1, extracellular matrix protein
ST7 suppression of tumorigenicity 7
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit
TBC1D9B TBC1 domain family, member 9B (with GRAM domain)
TCTA T-cell leukemia translocation altered
TESC tescalcin
TGM2 transglutaminase 2
THTPA thiamine triphosphatase
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TMEM5 transmembrane protein 5
TPI1 triosephosphate isomerase 1
TRIM16 tripartite motif containing 16
UBE3C ubiquitin protein ligase E3C
ZNF451 zinc finger protein 451