BRD-K53423944_6-[4-(3-chlorophenyl)piperazin-1-yl]-3-cyclohexylpyrimidine-2,4(1H,3H)-dione_PC3_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

195 genes differentially expressed following the BRD-K53423944_6-[4-(3-chlorophenyl)piperazin-1-yl]-3-cyclohexylpyrimidine-2,4(1H,3H)-dione_PC3_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAMDEC1 ADAM-like, decysin 1
ARMCX1 armadillo repeat containing, X-linked 1
ATF3 activating transcription factor 3
BTG1 B-cell translocation gene 1, anti-proliferative
C6ORF62 chromosome 6 open reading frame 62
CA4 carbonic anhydrase IV
CALD1 caldesmon 1
CASP1 caspase 1, apoptosis-related cysteine peptidase
CASP10 caspase 10, apoptosis-related cysteine peptidase
CD14 CD14 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD9 CD9 molecule
CD93 CD93 molecule
CLC Charcot-Leyden crystal galectin
CLEC5A C-type lectin domain family 5, member A
COL1A2 collagen, type I, alpha 2
COLEC12 collectin sub-family member 12
CXCL14 chemokine (C-X-C motif) ligand 14
CXCR4 chemokine (C-X-C motif) receptor 4
CYBB cytochrome b-245, beta polypeptide
DCN decorin
DSP desmoplakin
FGL2 fibrinogen-like 2
FOS FBJ murine osteosarcoma viral oncogene homolog
GADD45B growth arrest and DNA-damage-inducible, beta
GLUL glutamate-ammonia ligase
GPM6B glycoprotein M6B
GPNMB glycoprotein (transmembrane) nmb
GPR183 G protein-coupled receptor 183
HIST1H1C histone cluster 1, H1c
HIST1H2AE histone cluster 1, H2ae
HIST1H2BG histone cluster 1, H2bg
HIST2H2BE histone cluster 2, H2be
HLA-C major histocompatibility complex, class I, C
HLA-F major histocompatibility complex, class I, F
HSPA1A heat shock 70kDa protein 1A
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IFI6 interferon, alpha-inducible protein 6
IGFBP5 insulin-like growth factor binding protein 5
IGFBP7 insulin-like growth factor binding protein 7
IGHM immunoglobulin heavy constant mu
IGKV4-1 immunoglobulin kappa variable 4-1
INSM1 insulinoma-associated 1
ISG15 ISG15 ubiquitin-like modifier
JUN jun proto-oncogene
KLF9 Kruppel-like factor 9
LAMP5 lysosomal-associated membrane protein family, member 5
LPAR6 lysophosphatidic acid receptor 6
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAGEA3 melanoma antigen family A3
MED17 mediator complex subunit 17
MMP12 matrix metallopeptidase 12
MMP9 matrix metallopeptidase 9
MS4A12 membrane-spanning 4-domains, subfamily A, member 12
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1H metallothionein 1H
NCAM1 neural cell adhesion molecule 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PBX3 pre-B-cell leukemia homeobox 3
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PGK1 phosphoglycerate kinase 1
PID1 phosphotyrosine interaction domain containing 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
POSTN periostin, osteoblast specific factor
PTPRD protein tyrosine phosphatase, receptor type, D
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RGS5 regulator of G-protein signaling 5
SERINC5 serine incorporator 5
SGK1 serum/glucocorticoid regulated kinase 1
SPARCL1 SPARC-like 1 (hevin)
TEK TEK tyrosine kinase, endothelial
TF transferrin
THBS1 thrombospondin 1
TSPAN7 tetraspanin 7
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABLIM1 actin binding LIM protein 1
ACTN1 actinin, alpha 1
ADGRE5 adhesion G protein-coupled receptor E5
AK1 adenylate kinase 1
AKAP10 A kinase (PRKA) anchor protein 10
AKR1C3 aldo-keto reductase family 1, member C3
ALCAM activated leukocyte cell adhesion molecule
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
AQP3 aquaporin 3 (Gill blood group)
ARFIP2 ADP-ribosylation factor interacting protein 2
ARMCX6 armadillo repeat containing, X-linked 6
ASS1 argininosuccinate synthase 1
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BIK BCL2-interacting killer (apoptosis-inducing)
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C14ORF1 chromosome 14 open reading frame 1
C1ORF106 chromosome 1 open reading frame 106
C1ORF116 chromosome 1 open reading frame 116
C8ORF4 chromosome 8 open reading frame 4
CD151 CD151 molecule (Raph blood group)
CDC25B cell division cycle 25B
CDK4 cyclin-dependent kinase 4
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CLDN10 claudin 10
CP ceruloplasmin (ferroxidase)
CTSE cathepsin E
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL6 chemokine (C-X-C motif) ligand 6
DIMT1 DIM1 dimethyladenosine transferase 1 homolog (S. cerevisiae)
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
EIF5 eukaryotic translation initiation factor 5
ERBB2 erb-b2 receptor tyrosine kinase 2
FHL2 four and a half LIM domains 2
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14
GAS1 growth arrest-specific 1
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type
GMDS GDP-mannose 4,6-dehydratase
GSTP1 glutathione S-transferase pi 1
HDDC2 HD domain containing 2
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KIAA0125 KIAA0125
KLK11 kallikrein-related peptidase 11
KRT7 keratin 7, type II
LAMA3 laminin, alpha 3
LAMB3 laminin, beta 3
LDLR low density lipoprotein receptor
LOXL1 lysyl oxidase-like 1
LRBA LPS-responsive vesicle trafficking, beach and anchor containing
LRP10 low density lipoprotein receptor-related protein 10
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAPK13 mitogen-activated protein kinase 13
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MGLL monoglyceride lipase
MPRIP myosin phosphatase Rho interacting protein
MRPL12 mitochondrial ribosomal protein L12
MUC5B mucin 5B, oligomeric mucus/gel-forming
MYH10 myosin, heavy chain 10, non-muscle
NIPSNAP1 nipsnap homolog 1 (C. elegans)
NUP210 nucleoporin 210kDa
NUP43 nucleoporin 43kDa
NUP62 nucleoporin 62kDa
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
ODC1 ornithine decarboxylase 1
PARP4 poly (ADP-ribose) polymerase family, member 4
PCMT1 protein-L-isoaspartate (D-aspartate) O-methyltransferase
PLA2G16 phospholipase A2, group XVI
PLS1 plastin 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRKCD protein kinase C, delta
PROM1 prominin 1
PRSS2 protease, serine, 2 (trypsin 2)
PRSS3 protease, serine, 3
PSCA prostate stem cell antigen
PTGES prostaglandin E synthase
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBMS1 RNA binding motif, single stranded interacting protein 1
RBPMS RNA binding protein with multiple splicing
RHOF ras homolog family member F (in filopodia)
RPL36AL ribosomal protein L36a-like
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
S100A11 S100 calcium binding protein A11
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SKIV2L superkiller viralicidic activity 2-like (S. cerevisiae)
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC25A46 solute carrier family 25, member 46
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SREBF1 sterol regulatory element binding transcription factor 1
STEAP3 STEAP family member 3, metalloreductase
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SYNGR2 synaptogyrin 2
TBC1D8 TBC1 domain family, member 8 (with GRAM domain)
TBL1X transducin (beta)-like 1X-linked
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TESC tescalcin
TFF2 trefoil factor 2
TGM2 transglutaminase 2
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TM4SF1 transmembrane 4 L six family member 1
TMEM135 transmembrane protein 135
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TOP2A topoisomerase (DNA) II alpha 170kDa
TRIM16 tripartite motif containing 16
TRIOBP TRIO and F-actin binding protein
TSPAN8 tetraspanin 8
TXNDC9 thioredoxin domain containing 9
UBAP2 ubiquitin associated protein 2
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VCL vinculin
WDR61 WD repeat domain 61
XPO1 exportin 1
ZMYM2 zinc finger, MYM-type 2