BRD-K53423944_6-[4-(3-chlorophenyl)piperazin-1-yl]-3-cyclohexylpyrimidine-2,4(1H,3H)-dione_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

217 genes differentially expressed following the BRD-K53423944_6-[4-(3-chlorophenyl)piperazin-1-yl]-3-cyclohexylpyrimidine-2,4(1H,3H)-dione_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ADGRL4 adhesion G protein-coupled receptor L4
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
AQP1 aquaporin 1 (Colton blood group)
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ATF3 activating transcription factor 3
BEX4 brain expressed, X-linked 4
C1ORF54 chromosome 1 open reading frame 54
C3ORF14 chromosome 3 open reading frame 14
CA4 carbonic anhydrase IV
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAV1 caveolin 1, caveolae protein, 22kDa
CCK cholecystokinin
CCL8 chemokine (C-C motif) ligand 8
CD24 CD24 molecule
CD52 CD52 molecule
CD69 CD69 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD9 CD9 molecule
CD93 CD93 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CKB creatine kinase, brain
CLC Charcot-Leyden crystal galectin
CLDN5 claudin 5
CLIC5 chloride intracellular channel 5
COL3A1 collagen, type III, alpha 1
CPE carboxypeptidase E
CPQ carboxypeptidase Q
CRIP2 cysteine-rich protein 2
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
CTGF connective tissue growth factor
CXCL14 chemokine (C-X-C motif) ligand 14
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DEFA4 defensin, alpha 4, corticostatin
ELOVL4 ELOVL fatty acid elongase 4
EMP1 epithelial membrane protein 1
EMP2 epithelial membrane protein 2
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FABP4 fatty acid binding protein 4, adipocyte
FASTKD5 FAST kinase domains 5
FBXO11 F-box protein 11
FLT1 fms-related tyrosine kinase 1
FSD1 fibronectin type III and SPRY domain containing 1
G0S2 G0/G1 switch 2
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GJA1 gap junction protein, alpha 1, 43kDa
GPM6B glycoprotein M6B
GPNMB glycoprotein (transmembrane) nmb
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IGF1 insulin-like growth factor 1 (somatomedin C)
IGLL1 immunoglobulin lambda-like polypeptide 1
JUP junction plakoglobin
KLF10 Kruppel-like factor 10
KRT5 keratin 5, type II
LAPTM4B lysosomal protein transmembrane 4 beta
LCN2 lipocalin 2
LPAR6 lysophosphatidic acid receptor 6
LRRC17 leucine rich repeat containing 17
LTB lymphotoxin beta (TNF superfamily, member 3)
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MME membrane metallo-endopeptidase
MMP9 matrix metallopeptidase 9
NCF4 neutrophil cytosolic factor 4, 40kDa
NDRG1 N-myc downstream regulated 1
NEFH neurofilament, heavy polypeptide
NELL2 NEL-like 2 (chicken)
OLFM1 olfactomedin 1
PCLO piccolo presynaptic cytomatrix protein
PDGFD platelet derived growth factor D
PECAM1 platelet/endothelial cell adhesion molecule 1
PFN2 profilin 2
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLBD1 phospholipase B domain containing 1
PLEKHF2 pleckstrin homology domain containing, family F (with FYVE domain) member 2
PLTP phospholipid transfer protein
PNPLA4 patatin-like phospholipase domain containing 4
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
QPCT glutaminyl-peptide cyclotransferase
RGCC regulator of cell cycle
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
S100A8 S100 calcium binding protein A8
SDC2 syndecan 2
SELE selectin E
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFN stratifin
SGK1 serum/glucocorticoid regulated kinase 1
SLIT2 slit homolog 2 (Drosophila)
SOX4 SRY (sex determining region Y)-box 4
SPARCL1 SPARC-like 1 (hevin)
SST somatostatin
STS steroid sulfatase (microsomal), isozyme S
SULF1 sulfatase 1
SYT1 synaptotagmin I
TEK TEK tyrosine kinase, endothelial
TMSB15A thymosin beta 15a
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TUBA1A tubulin, alpha 1a
TUSC3 tumor suppressor candidate 3
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UGCG UDP-glucose ceramide glucosyltransferase
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
XIST X inactive specific transcript (non-protein coding)
ZNF423 zinc finger protein 423

decreased expression

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
AFF1 AF4/FMR2 family, member 1
AKAP11 A kinase (PRKA) anchor protein 11
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ANKRD17 ankyrin repeat domain 17
ANKRD28 ankyrin repeat domain 28
ARHGAP5 Rho GTPase activating protein 5
ASXL2 additional sex combs like transcriptional regulator 2
ATR ATR serine/threonine kinase
ATXN1 ataxin 1
BASP1 brain abundant, membrane attached signal protein 1
BAZ1A bromodomain adjacent to zinc finger domain, 1A
C2CD2 C2 calcium-dependent domain containing 2
CAPRIN2 caprin family member 2
CCNF cyclin F
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDK19 cyclin-dependent kinase 19
CDR2L cerebellar degeneration-related protein 2-like
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEMIP cell migration inducing protein, hyaluronan binding
CENPE centromere protein E, 312kDa
CEP350 centrosomal protein 350kDa
COL9A3 collagen, type IX, alpha 3
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CRTC3 CREB regulated transcription coactivator 3
CSTF3 cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa
CTSE cathepsin E
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DENND5A DENN/MADD domain containing 5A
DHRS2 dehydrogenase/reductase (SDR family) member 2
DKK1 dickkopf WNT signaling pathway inhibitor 1
DST dystonin
EDRF1 erythroid differentiation regulatory factor 1
FAM208B family with sequence similarity 208, member B
FAM216A family with sequence similarity 216, member A
FAM35A family with sequence similarity 35, member A
FAM57A family with sequence similarity 57, member A
FKBP11 FK506 binding protein 11, 19 kDa
FNBP4 formin binding protein 4
FNDC3A fibronectin type III domain containing 3A
FNDC3B fibronectin type III domain containing 3B
GPATCH8 G patch domain containing 8
GSAP gamma-secretase activating protein
HEATR1 HEAT repeat containing 1
HOPX HOP homeobox
HOXC10 homeobox C10
HOXC6 homeobox C6
INPP5A inositol polyphosphate-5-phosphatase, 40kDa
JADE1 jade family PHD finger 1
JMJD6 jumonji domain containing 6
KIF2C kinesin family member 2C
KRT7 keratin 7, type II
KYNU kynureninase
LARP4 La ribonucleoprotein domain family, member 4
LOC100272216 uncharacterized LOC100272216
LYST lysosomal trafficking regulator
MACF1 microtubule-actin crosslinking factor 1
MALT1 MALT1 paracaspase
MAP3K4 mitogen-activated protein kinase kinase kinase 4
MBNL2 muscleblind-like splicing regulator 2
MDN1 MDN1, midasin homolog (yeast)
MED13 mediator complex subunit 13
MELK maternal embryonic leucine zipper kinase
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MSLN mesothelin
NOC3L nucleolar complex associated 3 homolog (S. cerevisiae)
NUP62 nucleoporin 62kDa
PACSIN3 protein kinase C and casein kinase substrate in neurons 3
PCM1 pericentriolar material 1
PDLIM5 PDZ and LIM domain 5
PDS5A PDS5 cohesin associated factor A
PFKP phosphofructokinase, platelet
PHF3 PHD finger protein 3
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PLAC8 placenta-specific 8
PMS1 PMS1 postmeiotic segregation increased 1 (S. cerevisiae)
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PRKCA protein kinase C, alpha
PTPN12 protein tyrosine phosphatase, non-receptor type 12
PURA purine-rich element binding protein A
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RRP1B ribosomal RNA processing 1B
RUNX3 runt-related transcription factor 3
SACS sacsin molecular chaperone
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC16A6 solute carrier family 16, member 6
SON SON DNA binding protein
SPATS2L spermatogenesis associated, serine-rich 2-like
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SYNJ2 synaptojanin 2
TBL1X transducin (beta)-like 1X-linked
TBP TATA box binding protein
TCERG1 transcription elongation regulator 1
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TESC tescalcin
TGM2 transglutaminase 2
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TMEM2 transmembrane protein 2
TMEM5 transmembrane protein 5
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
UBE3C ubiquitin protein ligase E3C
USP34 ubiquitin specific peptidase 34
WAC WW domain containing adaptor with coiled-coil
XBP1 X-box binding protein 1
ZNF22 zinc finger protein 22
ZNF451 zinc finger protein 451