BRD-K53423944_6-[4-(3-chlorophenyl)piperazin-1-yl]-3-cyclohexylpyrimidine-2,4(1H,3H)-dione_HA1E_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

120 genes differentially expressed following the BRD-K53423944_6-[4-(3-chlorophenyl)piperazin-1-yl]-3-cyclohexylpyrimidine-2,4(1H,3H)-dione_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ACPP acid phosphatase, prostate
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b
BAMBI BMP and activin membrane-bound inhibitor
BCL6 B-cell CLL/lymphoma 6
BRD2 bromodomain containing 2
CA2 carbonic anhydrase II
CA4 carbonic anhydrase IV
CD36 CD36 molecule (thrombospondin receptor)
CELF2 CUGBP, Elav-like family member 2
CLU clusterin
CPB1 carboxypeptidase B1 (tissue)
CPE carboxypeptidase E
CXADR coxsackie virus and adenovirus receptor
CXCL9 chemokine (C-X-C motif) ligand 9
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DUSP22 dual specificity phosphatase 22
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
F11R F11 receptor
FASTKD5 FAST kinase domains 5
FST follistatin
GADD45B growth arrest and DNA-damage-inducible, beta
GPM6B glycoprotein M6B
GSN gelsolin
GSTA1 glutathione S-transferase alpha 1
HIST1H2BG histone cluster 1, H2bg
HIST1H4C histone cluster 1, H4c
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IDI1 isopentenyl-diphosphate delta isomerase 1
IDO1 indoleamine 2,3-dioxygenase 1
ISOC1 isochorismatase domain containing 1
JUND jun D proto-oncogene
KRT5 keratin 5, type II
MAN1A1 mannosidase, alpha, class 1A, member 1
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MMP9 matrix metallopeptidase 9
MPO myeloperoxidase
MSMB microseminoprotein, beta-
NPTX2 neuronal pentraxin II
OLFM4 olfactomedin 4
ORM1 orosomucoid 1
PELI1 pellino E3 ubiquitin protein ligase 1
PLAGL1 pleiomorphic adenoma gene-like 1
PPP1R16B protein phosphatase 1, regulatory subunit 16B
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRDX2 peroxiredoxin 2
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
RGCC regulator of cell cycle
RNASE4 ribonuclease, RNase A family, 4
RNF11 ring finger protein 11
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
S100P S100 calcium binding protein P
SCGB1D2 secretoglobin, family 1D, member 2
SFN stratifin
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SOD2 superoxide dismutase 2, mitochondrial
SQLE squalene epoxidase
SST somatostatin
STOM stomatin
STS steroid sulfatase (microsomal), isozyme S
TARP TCR gamma alternate reading frame protein
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM47 transmembrane protein 47
TUBB2A tubulin, beta 2A class IIa
XIST X inactive specific transcript (non-protein coding)
ZFP36L2 ZFP36 ring finger protein-like 2

decreased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ANKRD10 ankyrin repeat domain 10
ASXL2 additional sex combs like transcriptional regulator 2
BAZ1A bromodomain adjacent to zinc finger domain, 1A
C1RL complement component 1, r subcomponent-like
CCNF cyclin F
CDK12 cyclin-dependent kinase 12
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene
CSTF3 cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa
CX3CR1 chemokine (C-X3-C motif) receptor 1
DEFB1 defensin, beta 1
DHRS2 dehydrogenase/reductase (SDR family) member 2
EHBP1 EH domain binding protein 1
FAM208A family with sequence similarity 208, member A
FOXD1 forkhead box D1
GLS glutaminase
GOLGA8A golgin A8 family, member A
GRAMD3 GRAM domain containing 3
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGA2 high mobility group AT-hook 2
HOXC6 homeobox C6
KIF14 kinesin family member 14
KRT7 keratin 7, type II
LOC100505650 uncharacterized LOC100505650
MBNL2 muscleblind-like splicing regulator 2
MET MET proto-oncogene, receptor tyrosine kinase
MTA1 metastasis associated 1
MX2 MX dynamin-like GTPase 2
NUP62 nucleoporin 62kDa
PAX8 paired box 8
PCGF2 polycomb group ring finger 2
PFKP phosphofructokinase, platelet
PIK3R4 phosphoinositide-3-kinase, regulatory subunit 4
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PPP1R10 protein phosphatase 1, regulatory subunit 10
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RPL31 ribosomal protein L31
S100A2 S100 calcium binding protein A2
SLPI secretory leukocyte peptidase inhibitor
SPATA20 spermatogenesis associated 20
STXBP1 syntaxin binding protein 1
SYNRG synergin, gamma
TGM2 transglutaminase 2
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TMEM100 transmembrane protein 100
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
WNT5A wingless-type MMTV integration site family, member 5A