BRD-K53423944_6-[4-(3-chlorophenyl)piperazin-1-yl]-3-cyclohexylpyrimidine-2,4(1H,3H)-dione_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

68 genes differentially expressed following the BRD-K53423944_6-[4-(3-chlorophenyl)piperazin-1-yl]-3-cyclohexylpyrimidine-2,4(1H,3H)-dione_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AGR2 anterior gradient 2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
BMP2 bone morphogenetic protein 2
CD24 CD24 molecule
CDC42 cell division cycle 42
CLU clusterin
COMP cartilage oligomeric matrix protein
CRISP3 cysteine-rich secretory protein 3
DSP desmoplakin
EMP1 epithelial membrane protein 1
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
EZR ezrin
F2RL1 coagulation factor II (thrombin) receptor-like 1
GLUL glutamate-ammonia ligase
IL1R1 interleukin 1 receptor, type I
JAG1 jagged 1
LYZ lysozyme
MIR22HG MIR22 host gene
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RBP4 retinol binding protein 4, plasma
RGS2 regulator of G-protein signaling 2
S100A8 S100 calcium binding protein A8
S100P S100 calcium binding protein P
SORBS1 sorbin and SH3 domain containing 1
SULF1 sulfatase 1
TFF1 trefoil factor 1
TSPAN13 tetraspanin 13
TXNIP thioredoxin interacting protein

decreased expression

Symbol Name
BACE2 beta-site APP-cleaving enzyme 2
C2CD5 C2 calcium-dependent domain containing 5
CD58 CD58 molecule
CSRP2 cysteine and glycine-rich protein 2
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
GNAS GNAS complex locus
GPX1 glutathione peroxidase 1
GUSBP11 glucuronidase, beta pseudogene 11
IPO13 importin 13
JMJD6 jumonji domain containing 6
LAPTM4B lysosomal protein transmembrane 4 beta
LY6E lymphocyte antigen 6 complex, locus E
MACF1 microtubule-actin crosslinking factor 1
MAGEA12 melanoma antigen family A12
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MET MET proto-oncogene, receptor tyrosine kinase
MOCOS molybdenum cofactor sulfurase
N4BP2L1 NEDD4 binding protein 2-like 1
NEFL neurofilament, light polypeptide
NRN1 neuritin 1
NVL nuclear VCP-like
PFKP phosphofructokinase, platelet
PLEKHA5 pleckstrin homology domain containing, family A member 5
RAD51C RAD51 paralog C
RNMT RNA (guanine-7-) methyltransferase
RPA2 replication protein A2, 32kDa
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast)
TOP2A topoisomerase (DNA) II alpha 170kDa
TRIP6 thyroid hormone receptor interactor 6
TUBB6 tubulin, beta 6 class V
VCAN versican