BRD-K53414658_tivozanib_HA1E_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

59 genes differentially expressed following the BRD-K53414658_tivozanib_HA1E_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
BPHL biphenyl hydrolase-like (serine hydrolase)
CCNA1 cyclin A1
CLDN3 claudin 3
COL5A2 collagen, type V, alpha 2
CTSB cathepsin B
CXCL2 chemokine (C-X-C motif) ligand 2
EGF epidermal growth factor
GREM1 gremlin 1, DAN family BMP antagonist
INHBA inhibin, beta A
LEF1 lymphoid enhancer-binding factor 1
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NME4 NME/NM23 nucleoside diphosphate kinase 4
NRIP1 nuclear receptor interacting protein 1
POSTN periostin, osteoblast specific factor
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RGS4 regulator of G-protein signaling 4
SCGB2A2 secretoglobin, family 2A, member 2
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SRGN serglycin
SRSF6 serine/arginine-rich splicing factor 6
SYT1 synaptotagmin I
TBX3 T-box 3
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR1 atypical chemokine receptor 1 (Duffy blood group)
BIN1 bridging integrator 1
CCND2 cyclin D2
CD36 CD36 molecule (thrombospondin receptor)
CHN2 chimerin 2
CXCL14 chemokine (C-X-C motif) ligand 14
DHCR24 24-dehydrocholesterol reductase
DPYSL2 dihydropyrimidinase-like 2
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
G0S2 G0/G1 switch 2
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GPX3 glutathione peroxidase 3
IFI27 interferon, alpha-inducible protein 27
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
ITGB1BP1 integrin beta 1 binding protein 1
KLK10 kallikrein-related peptidase 10
KLK11 kallikrein-related peptidase 11
KLK6 kallikrein-related peptidase 6
KRT19 keratin 19, type I
LAT2 linker for activation of T cells family, member 2
MGLL monoglyceride lipase
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
OSBPL3 oxysterol binding protein-like 3
PNP purine nucleoside phosphorylase
PROM1 prominin 1
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
S100A7 S100 calcium binding protein A7
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3
SLC43A3 solute carrier family 43, member 3
STAT1 signal transducer and activator of transcription 1, 91kDa
TM4SF1 transmembrane 4 L six family member 1
ZBTB18 zinc finger and BTB domain containing 18