BRD-K53281329_SYK-inhibitor_HCC515_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

93 genes differentially expressed following the BRD-K53281329_SYK-inhibitor_HCC515_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF4 activating transcription factor 4
ATM ATM serine/threonine kinase
CD1E CD1e molecule
CIRBP cold inducible RNA binding protein
CLNS1A chloride channel, nucleotide-sensitive, 1A
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family)
DKK3 dickkopf WNT signaling pathway inhibitor 3
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
F3 coagulation factor III (thromboplastin, tissue factor)
FAM129A family with sequence similarity 129, member A
FAM69A family with sequence similarity 69, member A
G0S2 G0/G1 switch 2
GREM1 gremlin 1, DAN family BMP antagonist
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
IRS2 insulin receptor substrate 2
METRN meteorin, glial cell differentiation regulator
MMP3 matrix metallopeptidase 3
MYBPC1 myosin binding protein C, slow type
PHGDH phosphoglycerate dehydrogenase
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PLK2 polo-like kinase 2
PSAT1 phosphoserine aminotransferase 1
PSPH phosphoserine phosphatase
PYCR1 pyrroline-5-carboxylate reductase 1
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SNAI2 snail family zinc finger 2
SOX9 SRY (sex determining region Y)-box 9
STC2 stanniocalcin 2
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
TFF3 trefoil factor 3 (intestinal)
THBS4 thrombospondin 4
TNC tenascin C

decreased expression

Symbol Name
AEBP1 AE binding protein 1
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide
BACE2 beta-site APP-cleaving enzyme 2
C1QB complement component 1, q subcomponent, B chain
C7 complement component 7
CCL2 chemokine (C-C motif) ligand 2
CCL5 chemokine (C-C motif) ligand 5
CD14 CD14 molecule
CD163 CD163 molecule
CD24 CD24 molecule
CD47 CD47 molecule
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CKB creatine kinase, brain
CLIC3 chloride intracellular channel 3
CLTC clathrin, heavy chain (Hc)
CLU clusterin
COCH cochlin
CYCS cytochrome c, somatic
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DMTF1 cyclin D binding myb-like transcription factor 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ERBB2 erb-b2 receptor tyrosine kinase 2
FAM162A family with sequence similarity 162, member A
HK1 hexokinase 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IFI27 interferon, alpha-inducible protein 27
IGSF3 immunoglobulin superfamily, member 3
ITGB5 integrin, beta 5
KRT1 keratin 1, type II
LXN latexin
MATN2 matrilin 2
MGP matrix Gla protein
MTUS1 microtubule associated tumor suppressor 1
NSDHL NAD(P) dependent steroid dehydrogenase-like
NSG1 neuron specific gene family member 1
PCP4 Purkinje cell protein 4
PLBD1 phospholipase B domain containing 1
PON3 paraoxonase 3
RAI2 retinoic acid induced 2
RPS4Y1 ribosomal protein S4, Y-linked 1
S100A7 S100 calcium binding protein A7
S100A9 S100 calcium binding protein A9
SCEL sciellin
SLPI secretory leukocyte peptidase inhibitor
SPINK5 serine peptidase inhibitor, Kazal type 5
SPTSSA serine palmitoyltransferase, small subunit A
STMN1 stathmin 1
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17
ZNF185 zinc finger protein 185 (LIM domain)