BRD-K53281329_SYK-inhibitor_A375_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

79 genes differentially expressed following the BRD-K53281329_SYK-inhibitor_A375_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABLIM1 actin binding LIM protein 1
ACKR3 atypical chemokine receptor 3
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ANXA4 annexin A4
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
ITM2A integral membrane protein 2A
KYNU kynureninase
LYN LYN proto-oncogene, Src family tyrosine kinase
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3
MSRB2 methionine sulfoxide reductase B2
MXRA5 matrix-remodelling associated 5
NGRN neugrin, neurite outgrowth associated
NUPR1 nuclear protein, transcriptional regulator, 1
OLFM1 olfactomedin 1
OPHN1 oligophrenin 1
PCYOX1L prenylcysteine oxidase 1 like
PHGDH phosphoglycerate dehydrogenase
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
PYCR1 pyrroline-5-carboxylate reductase 1
RNASET2 ribonuclease T2
SELL selectin L
SERTAD2 SERTA domain containing 2
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
TPP1 tripeptidyl peptidase I
TSPAN7 tetraspanin 7
WDR61 WD repeat domain 61
XIST X inactive specific transcript (non-protein coding)
ZMAT3 zinc finger, matrin-type 3
ZNF589 zinc finger protein 589
ZW10 zw10 kinetochore protein

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADI1 acireductone dioxygenase 1
AMIGO2 adhesion molecule with Ig-like domain 2
ARG2 arginase 2
BPHL biphenyl hydrolase-like (serine hydrolase)
CAPZB capping protein (actin filament) muscle Z-line, beta
CCL5 chemokine (C-C motif) ligand 5
CHN2 chimerin 2
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit
COL1A2 collagen, type I, alpha 2
COL6A1 collagen, type VI, alpha 1
COL6A2 collagen, type VI, alpha 2
CYTIP cytohesin 1 interacting protein
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FCGBP Fc fragment of IgG binding protein
FKBP11 FK506 binding protein 11, 19 kDa
FSTL1 follistatin-like 1
HSPA2 heat shock 70kDa protein 2
IFI16 interferon, gamma-inducible protein 16
IFITM3 interferon induced transmembrane protein 3
IGHM immunoglobulin heavy constant mu
IL13RA2 interleukin 13 receptor, alpha 2
LAMB1 laminin, beta 1
LAMC1 laminin, gamma 1 (formerly LAMB2)
LAPTM4B lysosomal protein transmembrane 4 beta
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRDX1 peroxiredoxin 1
PROM1 prominin 1
PTGER3 prostaglandin E receptor 3 (subtype EP3)
S100A2 S100 calcium binding protein A2
S100A7 S100 calcium binding protein A7
SFRP1 secreted frizzled-related protein 1
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPINK1 serine peptidase inhibitor, Kazal type 1
STK17A serine/threonine kinase 17a
STMN1 stathmin 1
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFPI2 tissue factor pathway inhibitor 2
TOP2A topoisomerase (DNA) II alpha 170kDa
TUBB2A tubulin, beta 2A class IIa
TYMS thymidylate synthetase
WWTR1 WW domain containing transcription regulator 1