BRD-K52911425_GDC-0941_HEPG2_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

137 genes differentially expressed following the BRD-K52911425_GDC-0941_HEPG2_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ANG angiogenin, ribonuclease, RNase A family, 5
APOD apolipoprotein D
ASS1 argininosuccinate synthase 1
BACE2 beta-site APP-cleaving enzyme 2
BASP1 brain abundant, membrane attached signal protein 1
BDH1 3-hydroxybutyrate dehydrogenase, type 1
C1RL complement component 1, r subcomponent-like
CD36 CD36 molecule (thrombospondin receptor)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CELF2 CUGBP, Elav-like family member 2
CHRDL1 chordin-like 1
CLGN calmegin
CP ceruloplasmin (ferroxidase)
CST1 cystatin SN
CST4 cystatin S
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DEFB1 defensin, beta 1
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EPB41L3 erythrocyte membrane protein band 4.1-like 3
ERBB3 erb-b2 receptor tyrosine kinase 3
FAM65B family with sequence similarity 65, member B
FGA fibrinogen alpha chain
FGG fibrinogen gamma chain
FGL1 fibrinogen-like 1
FKBP11 FK506 binding protein 11, 19 kDa
FOXN3 forkhead box N3
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
GPR137B G protein-coupled receptor 137B
GSTA4 glutathione S-transferase alpha 4
HNMT histamine N-methyltransferase
IGFBP1 insulin-like growth factor binding protein 1
IRS2 insulin receptor substrate 2
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2
KDM5D lysine (K)-specific demethylase 5D
LXN latexin
MLPH melanophilin
MTSS1 metastasis suppressor 1
MUC5B mucin 5B, oligomeric mucus/gel-forming
MVP major vault protein
N4BP2L1 NEDD4 binding protein 2-like 1
PDZK1IP1 PDZK1 interacting protein 1
PSAP prosaposin
RAB40B RAB40B, member RAS oncogene family
RAB4A RAB4A, member RAS oncogene family
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RGS10 regulator of G-protein signaling 10
RNASE4 ribonuclease, RNase A family, 4
RNF144A ring finger protein 144A
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
TBC1D8 TBC1 domain family, member 8 (with GRAM domain)
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TGM2 transglutaminase 2
TMC5 transmembrane channel-like 5
TMPRSS3 transmembrane protease, serine 3
TST thiosulfate sulfurtransferase (rhodanese)
TWF2 twinfilin actin binding protein 2
VDAC1 voltage-dependent anion channel 1
ZCCHC24 zinc finger, CCHC domain containing 24

decreased expression

Symbol Name
ADD3 adducin 3 (gamma)
ANPEP alanyl (membrane) aminopeptidase
ANXA1 annexin A1
AQP1 aquaporin 1 (Colton blood group)
AURKA aurora kinase A
CA2 carbonic anhydrase II
CAV1 caveolin 1, caveolae protein, 22kDa
CCNA2 cyclin A2
CCNB1 cyclin B1
CD320 CD320 molecule
CD34 CD34 molecule
CDC20 cell division cycle 20
CDKN3 cyclin-dependent kinase inhibitor 3
CEP55 centrosomal protein 55kDa
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHN1 chimerin 1
CKS2 CDC28 protein kinase regulatory subunit 2
COL15A1 collagen, type XV, alpha 1
COL1A1 collagen, type I, alpha 1
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL6A3 collagen, type VI, alpha 3
CXCL8 chemokine (C-X-C motif) ligand 8
DCN decorin
DHRS2 dehydrogenase/reductase (SDR family) member 2
DPYSL3 dihydropyrimidinase-like 3
ECT2 epithelial cell transforming 2
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF5A eukaryotic translation initiation factor 5A
EMP1 epithelial membrane protein 1
EREG epiregulin
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FGFR2 fibroblast growth factor receptor 2
FILIP1L filamin A interacting protein 1-like
FOSL1 FOS-like antigen 1
GABPB1 GA binding protein transcription factor, beta subunit 1
GINS1 GINS complex subunit 1 (Psf1 homolog)
H2AFX H2A histone family, member X
HAT1 histone acetyltransferase 1
HIST1H2BG histone cluster 1, H2bg
HSPA8 heat shock 70kDa protein 8
IGFBP7 insulin-like growth factor binding protein 7
IPO13 importin 13
ITM2A integral membrane protein 2A
KIF20A kinesin family member 20A
KRT19 keratin 19, type I
LUM lumican
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAGEA3 melanoma antigen family A3
MELK maternal embryonic leucine zipper kinase
NRN1 neuritin 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
ODC1 ornithine decarboxylase 1
PBK PDZ binding kinase
PHLDA1 pleckstrin homology-like domain, family A, member 1
POSTN periostin, osteoblast specific factor
PTMA prothymosin, alpha
RFC5 replication factor C (activator 1) 5, 36.5kDa
RGCC regulator of cell cycle
RNF138 ring finger protein 138, E3 ubiquitin protein ligase
RRM2 ribonucleotide reductase M2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SPC25 SPC25, NDC80 kinetochore complex component
SQRDL sulfide quinone reductase-like (yeast)
SSBP2 single-stranded DNA binding protein 2
STC2 stanniocalcin 2
TPM4 tropomyosin 4
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TPX2 TPX2, microtubule-associated
TSPAN7 tetraspanin 7
UBE2C ubiquitin-conjugating enzyme E2C
UBE2E3 ubiquitin-conjugating enzyme E2E 3
XIST X inactive specific transcript (non-protein coding)