BRD-K52911425_GDC-0941_HA1E_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

193 genes differentially expressed following the BRD-K52911425_GDC-0941_HA1E_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AAMDC adipogenesis associated, Mth938 domain containing
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ACTG2 actin, gamma 2, smooth muscle, enteric
AEBP1 AE binding protein 1
ANGPTL2 angiopoietin-like 2
ANXA4 annexin A4
ARL4C ADP-ribosylation factor-like 4C
ASPN asporin
ATP9A ATPase, class II, type 9A
C10ORF10 chromosome 10 open reading frame 10
C14ORF132 chromosome 14 open reading frame 132
C1QB complement component 1, q subcomponent, B chain
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAPG capping protein (actin filament), gelsolin-like
CCDC28A coiled-coil domain containing 28A
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD99 CD99 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CREBL2 cAMP responsive element binding protein-like 2
CTSD cathepsin D
CTSK cathepsin K
CXADR coxsackie virus and adenovirus receptor
DCHS1 dachsous cadherin-related 1
DKK3 dickkopf WNT signaling pathway inhibitor 3
DOCK4 dedicator of cytokinesis 4
DPYSL2 dihydropyrimidinase-like 2
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
EDN1 endothelin 1
EFNA1 ephrin-A1
ETHE1 ethylmalonic encephalopathy 1
ETV1 ets variant 1
FBLN1 fibulin 1
FCGBP Fc fragment of IgG binding protein
FCGRT Fc fragment of IgG, receptor, transporter, alpha
FOXN3 forkhead box N3
FOXO4 forkhead box O4
FXYD6 FXYD domain containing ion transport regulator 6
GLTSCR2 glioma tumor suppressor candidate region gene 2
GPNMB glycoprotein (transmembrane) nmb
GPR137B G protein-coupled receptor 137B
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
GRB7 growth factor receptor-bound protein 7
GRP gastrin-releasing peptide
GSDMB gasdermin B
GSN gelsolin
HBP1 HMG-box transcription factor 1
HMGB3 high mobility group box 3
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
HTRA1 HtrA serine peptidase 1
IER5 immediate early response 5
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
ING4 inhibitor of growth family, member 4
INSM1 insulinoma-associated 1
IRS2 insulin receptor substrate 2
ITGB5 integrin, beta 5
JUP junction plakoglobin
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KLHDC2 kelch domain containing 2
LGALS4 lectin, galactoside-binding, soluble, 4
LPCAT1 lysophosphatidylcholine acyltransferase 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAN1C1 mannosidase, alpha, class 1C, member 1
MAOA monoamine oxidase A
MFAP2 microfibrillar-associated protein 2
MLPH melanophilin
MMP11 matrix metallopeptidase 11
MMP2 matrix metallopeptidase 2
MTUS1 microtubule associated tumor suppressor 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NUAK1 NUAK family, SNF1-like kinase, 1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PBX1 pre-B-cell leukemia homeobox 1
PDPN podoplanin
PLSCR4 phospholipid scramblase 4
PSIP1 PC4 and SFRS1 interacting protein 1
PTPRO protein tyrosine phosphatase, receptor type, O
QPCT glutaminyl-peptide cyclotransferase
RAB13 RAB13, member RAS oncogene family
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3
SLC35E2B solute carrier family 35, member E2B
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SOX4 SRY (sex determining region Y)-box 4
SPINK1 serine peptidase inhibitor, Kazal type 1
SPINK4 serine peptidase inhibitor, Kazal type 4
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SPRY2 sprouty homolog 2 (Drosophila)
STON1 stonin 1
SWAP70 SWAP switching B-cell complex 70kDa subunit
SYNE2 spectrin repeat containing, nuclear envelope 2
TCEA2 transcription elongation factor A (SII), 2
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TGIF1 TGFB-induced factor homeobox 1
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM35 transmembrane protein 35
TMSB15A thymosin beta 15a
TPP1 tripeptidyl peptidase I
TRAPPC6A trafficking protein particle complex 6A
TRD T cell receptor delta locus
TRIM2 tripartite motif containing 2
TXNIP thioredoxin interacting protein
TYROBP TYRO protein tyrosine kinase binding protein
VAT1 vesicle amine transport 1

decreased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
AK4 adenylate kinase 4
ALDH18A1 aldehyde dehydrogenase 18 family, member A1
ALDOA aldolase A, fructose-bisphosphate
ALDOC aldolase C, fructose-bisphosphate
AMD1 adenosylmethionine decarboxylase 1
ASNS asparagine synthetase (glutamine-hydrolyzing)
BAG2 BCL2-associated athanogene 2
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BST2 bone marrow stromal cell antigen 2
CCL2 chemokine (C-C motif) ligand 2
CD58 CD58 molecule
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
DDIT4 DNA-damage-inducible transcript 4
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
DIRAS3 DIRAS family, GTP-binding RAS-like 3
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EGF epidermal growth factor
ENO1 enolase 1, (alpha)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase)
FAM162A family with sequence similarity 162, member A
FAM98A family with sequence similarity 98, member A
FKBP11 FK506 binding protein 11, 19 kDa
FKBP14 FK506 binding protein 14, 22 kDa
GCLM glutamate-cysteine ligase, modifier subunit
GLIPR1 GLI pathogenesis-related 1
GPC3 glypican 3
GPI glucose-6-phosphate isomerase
GSPT1 G1 to S phase transition 1
GSTM3 glutathione S-transferase mu 3 (brain)
HIGD1A HIG1 hypoxia inducible domain family, member 1A
IGFBP3 insulin-like growth factor binding protein 3
IL6ST interleukin 6 signal transducer
INSIG1 insulin induced gene 1
KRT10 keratin 10, type I
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAL mal, T-cell differentiation protein
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MOK MOK protein kinase
MSMO1 methylsterol monooxygenase 1
NKX3-1 NK3 homeobox 1
NOP16 NOP16 nucleolar protein
NPR3 natriuretic peptide receptor 3
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
OAT ornithine aminotransferase
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PAX8 paired box 8
PDXK pyridoxal (pyridoxine, vitamin B6) kinase
PGM1 phosphoglucomutase 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PNP purine nucleoside phosphorylase
PPIF peptidylprolyl isomerase F
PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12
QPRT quinolinate phosphoribosyltransferase
RCAN1 regulator of calcineurin 1
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A2 S100 calcium binding protein A2
SCARB1 scavenger receptor class B, member 1
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SPAG4 sperm associated antigen 4
SPATS2L spermatogenesis associated, serine-rich 2-like
SQLE squalene epoxidase
SRPRB signal recognition particle receptor, B subunit
STC2 stanniocalcin 2
TACSTD2 tumor-associated calcium signal transducer 2
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TFRC transferrin receptor
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
VLDLR very low density lipoprotein receptor
YARS tyrosyl-tRNA synthetase
YME1L1 YME1-like 1 ATPase