BRD-K52911425_GDC-0941_HA1E_24_h_0.12_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

104 genes differentially expressed following the BRD-K52911425_GDC-0941_HA1E_24_h_0.12_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
AMOTL2 angiomotin like 2
ARID5B AT rich interactive domain 5B (MRF1-like)
BAMBI BMP and activin membrane-bound inhibitor
C10ORF10 chromosome 10 open reading frame 10
CBR3 carbonyl reductase 3
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COL5A2 collagen, type V, alpha 2
CREBL2 cAMP responsive element binding protein-like 2
CSRP2 cysteine and glycine-rich protein 2
DHFR dihydrofolate reductase
DPYD dihydropyrimidine dehydrogenase
DUSP6 dual specificity phosphatase 6
E2F2 E2F transcription factor 2
ECM1 extracellular matrix protein 1
EDN1 endothelin 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
FOXG1 forkhead box G1
GREM1 gremlin 1, DAN family BMP antagonist
HIST1H4C histone cluster 1, H4c
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
IFI16 interferon, gamma-inducible protein 16
IFIT3 interferon-induced protein with tetratricopeptide repeats 3
IGLL1 immunoglobulin lambda-like polypeptide 1
IRS2 insulin receptor substrate 2
ITGB5 integrin, beta 5
KLHL2 kelch-like family member 2
KRAS Kirsten rat sarcoma viral oncogene homolog
LIMCH1 LIM and calponin homology domains 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MBP myelin basic protein
MMP1 matrix metallopeptidase 1
MTCL1 microtubule crosslinking factor 1
NREP neuronal regeneration related protein
PALLD palladin, cytoskeletal associated protein
PBX1 pre-B-cell leukemia homeobox 1
PROM1 prominin 1
PXDN peroxidasin
SOX4 SRY (sex determining region Y)-box 4
SPRY2 sprouty homolog 2 (Drosophila)
STK38L serine/threonine kinase 38 like
SULF1 sulfatase 1
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFPI2 tissue factor pathway inhibitor 2
TMSB15A thymosin beta 15a
TMSB15B thymosin beta 15B
TNPO1 transportin 1
TRIB2 tribbles pseudokinase 2
UGCG UDP-glucose ceramide glucosyltransferase
YPEL1 yippee-like 1 (Drosophila)
ZFAND5 zinc finger, AN1-type domain 5

decreased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ARG2 arginase 2
CALB1 calbindin 1, 28kDa
CCDC86 coiled-coil domain containing 86
CCND2 cyclin D2
CCR7 chemokine (C-C motif) receptor 7
CKB creatine kinase, brain
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DDIT4 DNA-damage-inducible transcript 4
DHCR24 24-dehydrocholesterol reductase
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
EGR1 early growth response 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM162A family with sequence similarity 162, member A
FASN fatty acid synthase
GATA2 GATA binding protein 2
HSPE1 heat shock 10kDa protein 1
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP3 insulin-like growth factor binding protein 3
IL1R2 interleukin 1 receptor, type II
IL6ST interleukin 6 signal transducer
INSIG1 insulin induced gene 1
ITGA6 integrin, alpha 6
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
MAL mal, T-cell differentiation protein
MAN1A1 mannosidase, alpha, class 1A, member 1
MSMB microseminoprotein, beta-
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NT5DC2 5'-nucleotidase domain containing 2
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PAX8 paired box 8
PGC progastricsin (pepsinogen C)
PRAME preferentially expressed antigen in melanoma
PSAT1 phosphoserine aminotransferase 1
PSPH phosphoserine phosphatase
S100A2 S100 calcium binding protein A2
SIAH2 siah E3 ubiquitin protein ligase 2
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SPAG4 sperm associated antigen 4
SUB1 SUB1 homolog (S. cerevisiae)
VDAC1 voltage-dependent anion channel 1