BRD-K52911425_GDC-0941_BT20_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

284 genes differentially expressed following the BRD-K52911425_GDC-0941_BT20_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AAMDC adipogenesis associated, Mth938 domain containing
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ABHD4 abhydrolase domain containing 4
ACKR3 atypical chemokine receptor 3
AKAP8L A kinase (PRKA) anchor protein 8-like
ANKRD10 ankyrin repeat domain 10
ANKRD36B ankyrin repeat domain 36B
APOD apolipoprotein D
AQP3 aquaporin 3 (Gill blood group)
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ARMCX1 armadillo repeat containing, X-linked 1
ATG14 autophagy related 14
ATHL1 ATH1, acid trehalase-like 1 (yeast)
AUH AU RNA binding protein/enoyl-CoA hydratase
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BAZ2B bromodomain adjacent to zinc finger domain, 2B
BCL3 B-cell CLL/lymphoma 3
BCL6 B-cell CLL/lymphoma 6
BTG1 B-cell translocation gene 1, anti-proliferative
C10ORF10 chromosome 10 open reading frame 10
C1RL complement component 1, r subcomponent-like
CALCOCO1 calcium binding and coiled-coil domain 1
CAST calpastatin
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CBX7 chromobox homolog 7
CCDC28A coiled-coil domain containing 28A
CCNG2 cyclin G2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDK19 cyclin-dependent kinase 19
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CELF2 CUGBP, Elav-like family member 2
CFB complement factor B
CHN2 chimerin 2
CLDN3 claudin 3
COBL cordon-bleu WH2 repeat protein
COL1A1 collagen, type I, alpha 1
CREBL2 cAMP responsive element binding protein-like 2
CTGF connective tissue growth factor
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYTH1 cytohesin 1
ECHDC2 enoyl CoA hydratase domain containing 2
ERBB3 erb-b2 receptor tyrosine kinase 3
F13A1 coagulation factor XIII, A1 polypeptide
FAM134C family with sequence similarity 134, member C
FOXN3 forkhead box N3
FOXO4 forkhead box O4
GALC galactosylceramidase
GAS6 growth arrest-specific 6
GBP2 guanylate binding protein 2, interferon-inducible
GLRX glutaredoxin (thioltransferase)
GLTSCR2 glioma tumor suppressor candidate region gene 2
GLUL glutamate-ammonia ligase
GPX1 glutathione peroxidase 1
GRN granulin
HBP1 HMG-box transcription factor 1
HCLS1 hematopoietic cell-specific Lyn substrate 1
HECA headcase homolog (Drosophila)
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST2H2BE histone cluster 2, H2be
HMOX1 heme oxygenase 1
HNMT histamine N-methyltransferase
HSPBAP1 HSPB (heat shock 27kDa) associated protein 1
IDUA iduronidase, alpha-L-
IFI27 interferon, alpha-inducible protein 27
IFITM1 interferon induced transmembrane protein 1
IL1R1 interleukin 1 receptor, type I
INSR insulin receptor
IRS2 insulin receptor substrate 2
ISCU iron-sulfur cluster assembly enzyme
JMJD1C jumonji domain containing 1C
KLHDC2 kelch domain containing 2
KLHL21 kelch-like family member 21
KLHL24 kelch-like family member 24
KLK11 kallikrein-related peptidase 11
LGALS8 lectin, galactoside-binding, soluble, 8
LMBRD1 LMBR1 domain containing 1
LRP10 low density lipoprotein receptor-related protein 10
LXN latexin
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
METTL7A methyltransferase like 7A
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MTSS1 metastasis suppressor 1
MUC16 mucin 16, cell surface associated
MVP major vault protein
MXI1 MAX interactor 1, dimerization protein
MYO1D myosin ID
MYO6 myosin VI
N4BP2L1 NEDD4 binding protein 2-like 1
NBR1 neighbor of BRCA1 gene 1
NEFL neurofilament, light polypeptide
NEK9 NIMA-related kinase 9
NOS3 nitric oxide synthase 3 (endothelial cell)
NPC2 Niemann-Pick disease, type C2
NUPR1 nuclear protein, transcriptional regulator, 1
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCMTD2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2
PELI2 pellino E3 ubiquitin protein ligase family member 2
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PNRC1 proline-rich nuclear receptor coactivator 1
PRUNE2 prune homolog 2 (Drosophila)
RALGDS ral guanine nucleotide dissociation stimulator
RB1CC1 RB1-inducible coiled-coil 1
RBM47 RNA binding motif protein 47
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
REXO2 RNA exonuclease 2
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RNASE4 ribonuclease, RNase A family, 4
RPS4Y1 ribosomal protein S4, Y-linked 1
RSRP1 arginine/serine-rich protein 1
RTN2 reticulon 2
SAT1 spermidine/spermine N1-acetyltransferase 1
SATB1 SATB homeobox 1
SCGB1D2 secretoglobin, family 1D, member 2
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SECISBP2L SECIS binding protein 2-like
SEPP1 selenoprotein P, plasma, 1
SERINC1 serine incorporator 1
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SGPL1 sphingosine-1-phosphate lyase 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SOS2 son of sevenless homolog 2 (Drosophila)
SOX4 SRY (sex determining region Y)-box 4
SQSTM1 sequestosome 1
SRSF5 serine/arginine-rich splicing factor 5
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
STAB1 stabilin 1
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
TMEM50A transmembrane protein 50A
TMEM59 transmembrane protein 59
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPP1 tripeptidyl peptidase I
TRAK2 trafficking protein, kinesin binding 2
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
WDR19 WD repeat domain 19
WDTC1 WD and tetratricopeptide repeats 1
WWP1 WW domain containing E3 ubiquitin protein ligase 1
YPEL5 yippee-like 5 (Drosophila)
ZBTB18 zinc finger and BTB domain containing 18
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ACAT2 acetyl-CoA acetyltransferase 2
ACTG2 actin, gamma 2, smooth muscle, enteric
AK4 adenylate kinase 4
AKAP12 A kinase (PRKA) anchor protein 12
ANXA10 annexin A10
AREG amphiregulin
ASF1B anti-silencing function 1B histone chaperone
ATAD2 ATPase family, AAA domain containing 2
BZW2 basic leucine zipper and W2 domains 2
CA2 carbonic anhydrase II
CALU calumenin
CCND1 cyclin D1
CD24 CD24 molecule
CD36 CD36 molecule (thrombospondin receptor)
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDK4 cyclin-dependent kinase 4
CENPN centromere protein N
CKS1B CDC28 protein kinase regulatory subunit 1B
CSE1L CSE1 chromosome segregation 1-like (yeast)
CSRP1 cysteine and glycine-rich protein 1
CTPS1 CTP synthase 1
CYCS cytochrome c, somatic
DCTPP1 dCTP pyrophosphatase 1
DHFR dihydrofolate reductase
DKC1 dyskeratosis congenita 1, dyskerin
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLC1 DLC1 Rho GTPase activating protein
DNM1L dynamin 1-like
DSCC1 DNA replication and sister chromatid cohesion 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
ENO1 enolase 1, (alpha)
FABP4 fatty acid binding protein 4, adipocyte
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FANCI Fanconi anemia, complementation group I
FBP1 fructose-1,6-bisphosphatase 1
FEN1 flap structure-specific endonuclease 1
FGFR3 fibroblast growth factor receptor 3
FHL1 four and a half LIM domains 1
FOSL1 FOS-like antigen 1
GAL galanin/GMAP prepropeptide
GFOD1 glucose-fructose oxidoreductase domain containing 1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GLDC glycine dehydrogenase (decarboxylating)
GPI glucose-6-phosphate isomerase
HAT1 histone acetyltransferase 1
HK2 hexokinase 2
HN1 hematological and neurological expressed 1
HOMER1 homer scaffolding protein 1
HSPA8 heat shock 70kDa protein 8
IARS isoleucyl-tRNA synthetase
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IFRD2 interferon-related developmental regulator 2
IL7R interleukin 7 receptor
ITGA6 integrin, alpha 6
JUN jun proto-oncogene
L1CAM L1 cell adhesion molecule
LAPTM4B lysosomal protein transmembrane 4 beta
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
MAP1B microtubule-associated protein 1B
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MELK maternal embryonic leucine zipper kinase
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MLEC malectin
MMP12 matrix metallopeptidase 12
MRPL12 mitochondrial ribosomal protein L12
MRPL17 mitochondrial ribosomal protein L17
MRTO4 mRNA turnover 4 homolog (S. cerevisiae)
MSH2 mutS homolog 2
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NME1 NME/NM23 nucleoside diphosphate kinase 1
NOLC1 nucleolar and coiled-body phosphoprotein 1
ODC1 ornithine decarboxylase 1
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PDIA4 protein disulfide isomerase family A, member 4
PDXK pyridoxal (pyridoxine, vitamin B6) kinase
PFKP phosphofructokinase, platelet
PGK1 phosphoglycerate kinase 1
PLN phospholamban
PNP purine nucleoside phosphorylase
POLR1E polymerase (RNA) I polypeptide E, 53kDa
PPARG peroxisome proliferator-activated receptor gamma
PPIF peptidylprolyl isomerase F
PPP1R1A protein phosphatase 1, regulatory (inhibitor) subunit 1A
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRDX4 peroxiredoxin 4
PRPF4 pre-mRNA processing factor 4
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3
PTGIS prostaglandin I2 (prostacyclin) synthase
PTRF polymerase I and transcript release factor
RAD51 RAD51 recombinase
RANBP1 RAN binding protein 1
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RFC4 replication factor C (activator 1) 4, 37kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RNASEH2A ribonuclease H2, subunit A
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
S100A2 S100 calcium binding protein A2
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
SDC1 syndecan 1
SDF2L1 stromal cell-derived factor 2-like 1
SEPT11 septin 11
SHCBP1 SHC SH2-domain binding protein 1
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SPP1 secreted phosphoprotein 1
SRM spermidine synthase
SRPRB signal recognition particle receptor, B subunit
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TFRC transferrin receptor
TGFA transforming growth factor, alpha
THBS2 thrombospondin 2
TK1 thymidine kinase 1, soluble
TMEM47 transmembrane protein 47
TMEM97 transmembrane protein 97
TPM1 tropomyosin 1 (alpha)
TRIP13 thyroid hormone receptor interactor 13
TUBB2A tubulin, beta 2A class IIa
TYMS thymidylate synthetase
UCHL5 ubiquitin carboxyl-terminal hydrolase L5
VRK1 vaccinia related kinase 1
ZWINT ZW10 interacting kinetochore protein