BRD-K52911425_GDC-0941_A375_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

211 genes differentially expressed following the BRD-K52911425_GDC-0941_A375_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8
ABLIM1 actin binding LIM protein 1
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AHNAK2 AHNAK nucleoprotein 2
ASS1 argininosuccinate synthase 1
ATP9A ATPase, class II, type 9A
BEX4 brain expressed, X-linked 4
BMP4 bone morphogenetic protein 4
C14ORF159 chromosome 14 open reading frame 159
C1RL complement component 1, r subcomponent-like
C6ORF48 chromosome 6 open reading frame 48
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAPN3 calpain 3, (p94)
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CES2 carboxylesterase 2
COL14A1 collagen, type XIV, alpha 1
CPQ carboxypeptidase Q
CTSA cathepsin A
CTSK cathepsin K
CUTA cutA divalent cation tolerance homolog (E. coli)
DCN decorin
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2
EPHA3 EPH receptor A3
EPS8 epidermal growth factor receptor pathway substrate 8
F2RL1 coagulation factor II (thrombin) receptor-like 1
FN1 fibronectin 1
FYCO1 FYVE and coiled-coil domain containing 1
GABARAP GABA(A) receptor-associated protein
GLTSCR2 glioma tumor suppressor candidate region gene 2
GOLGA8A golgin A8 family, member A
GOLGA8H golgin A8 family, member H
GPNMB glycoprotein (transmembrane) nmb
GPR137B G protein-coupled receptor 137B
GRN granulin
GSDMB gasdermin B
HBP1 HMG-box transcription factor 1
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HIGD2A HIG1 hypoxia inducible domain family, member 2A
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HMGA2 high mobility group AT-hook 2
IFI27 interferon, alpha-inducible protein 27
IFI44L interferon-induced protein 44-like
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFIT3 interferon-induced protein with tetratricopeptide repeats 3
IGF2R insulin-like growth factor 2 receptor
IGFBP6 insulin-like growth factor binding protein 6
LAMA4 laminin, alpha 4
LETMD1 LETM1 domain containing 1
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LPIN1 lipin 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MANSC1 MANSC domain containing 1
MET MET proto-oncogene, receptor tyrosine kinase
MGAT4B mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B
MPDZ multiple PDZ domain protein
MTMR11 myotubularin related protein 11
MTUS1 microtubule associated tumor suppressor 1
MVP major vault protein
MX1 MX dynamin-like GTPase 1
MX2 MX dynamin-like GTPase 2
MXI1 MAX interactor 1, dimerization protein
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NELL2 NEL-like 2 (chicken)
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NOV nephroblastoma overexpressed
NPDC1 neural proliferation, differentiation and control, 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NRN1 neuritin 1
NUPR1 nuclear protein, transcriptional regulator, 1
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
ORAI3 ORAI calcium release-activated calcium modulator 3
OSBPL1A oxysterol binding protein-like 1A
PAN2 PAN2 poly(A) specific ribonuclease subunit
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLCB4 phospholipase C, beta 4
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
RPL28 ribosomal protein L28
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
RSAD2 radical S-adenosyl methionine domain containing 2
SELENBP1 selenium binding protein 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLC22A18 solute carrier family 22, member 18
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
SLC35E2B solute carrier family 35, member E2B
SLC6A15 solute carrier family 6 (neutral amino acid transporter), member 15
SPATA20 spermatogenesis associated 20
SQSTM1 sequestosome 1
SSPN sarcospan
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SVIL supervillin
TCEAL4 transcription elongation factor A (SII)-like 4
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TFPI2 tissue factor pathway inhibitor 2
TGFBR3 transforming growth factor, beta receptor III
THBS2 thrombospondin 2
TM4SF1 transmembrane 4 L six family member 1
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TPCN1 two pore segment channel 1
TPP1 tripeptidyl peptidase I
TSPAN4 tetraspanin 4
WDR45 WD repeat domain 45
WIPI1 WD repeat domain, phosphoinositide interacting 1
WLS wntless Wnt ligand secretion mediator
ZNF277 zinc finger protein 277

decreased expression

Symbol Name
AK4 adenylate kinase 4
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ASF1B anti-silencing function 1B histone chaperone
ATAD2 ATPase family, AAA domain containing 2
AURKA aurora kinase A
BARD1 BRCA1 associated RING domain 1
BASP1 brain abundant, membrane attached signal protein 1
BIRC5 baculoviral IAP repeat containing 5
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CCNA2 cyclin A2
CCNF cyclin F
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDCA8 cell division cycle associated 8
CDH3 cadherin 3, type 1, P-cadherin (placental)
CDKN3 cyclin-dependent kinase inhibitor 3
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CSTA cystatin A (stefin A)
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DBF4 DBF4 zinc finger
DDIT4 DNA-damage-inducible transcript 4
DEFB1 defensin, beta 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
ESR1 estrogen receptor 1
EXO1 exonuclease 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FEN1 flap structure-specific endonuclease 1
FGFR3 fibroblast growth factor receptor 3
GCLM glutamate-cysteine ligase, modifier subunit
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GMNN geminin, DNA replication inhibitor
GSTP1 glutathione S-transferase pi 1
GTSE1 G-2 and S-phase expressed 1
HELLS helicase, lymphoid-specific
HJURP Holliday junction recognition protein
HMGB1 high mobility group box 1
HSPA14 heat shock 70kDa protein 14
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
KIF14 kinesin family member 14
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KLHL7 kelch-like family member 7
KRT14 keratin 14, type I
KRT5 keratin 5, type II
LMNB1 lamin B1
LMNB2 lamin B2
LTF lactotransferrin
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCM10 minichromosome maintenance complex component 10
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MKI67 marker of proliferation Ki-67
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MYB v-myb avian myeloblastosis viral oncogene homolog
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NCAPG non-SMC condensin I complex, subunit G
NLRP2 NLR family, pyrin domain containing 2
NUSAP1 nucleolar and spindle associated protein 1
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLE3 polymerase (DNA directed), epsilon 3, accessory subunit
PROM1 prominin 1
PRPF4 pre-mRNA processing factor 4
PSAT1 phosphoserine aminotransferase 1
PTBP3 polypyrimidine tract binding protein 3
RAD54B RAD54 homolog B (S. cerevisiae)
RGS2 regulator of G-protein signaling 2
RRM2 ribonucleotide reductase M2
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SEPHS1 selenophosphate synthetase 1
SFN stratifin
SHCBP1 SHC SH2-domain binding protein 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SMC2 structural maintenance of chromosomes 2
SPC25 SPC25, NDC80 kinetochore complex component
SRGN serglycin
SRSF7 serine/arginine-rich splicing factor 7
STIL SCL/TAL1 interrupting locus
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TMPO thymopoietin
TOP2A topoisomerase (DNA) II alpha 170kDa
TPM4 tropomyosin 4
TPX2 TPX2, microtubule-associated
TRIP13 thyroid hormone receptor interactor 13
TUBB2A tubulin, beta 2A class IIa
TUBB6 tubulin, beta 6 class V
TUBG1 tubulin, gamma 1
TXNDC9 thioredoxin domain containing 9
VRK1 vaccinia related kinase 1
XIST X inactive specific transcript (non-protein coding)