BRD-K52911425_-666_PC3_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

203 genes differentially expressed following the BRD-K52911425_-666_PC3_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ACKR3 atypical chemokine receptor 3
ADGRF5 adhesion G protein-coupled receptor F5
ALDOB aldolase B, fructose-bisphosphate
AMIGO2 adhesion molecule with Ig-like domain 2
ANKRD36B ankyrin repeat domain 36B
AREG amphiregulin
ATP9A ATPase, class II, type 9A
BASP1 brain abundant, membrane attached signal protein 1
BCAS1 breast carcinoma amplified sequence 1
BEX4 brain expressed, X-linked 4
C14ORF132 chromosome 14 open reading frame 132
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCNG2 cyclin G2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
CHGB chromogranin B
CLCA4 chloride channel accessory 4
CLIC5 chloride intracellular channel 5
COLEC12 collectin sub-family member 12
CP ceruloplasmin (ferroxidase)
CPT1A carnitine palmitoyltransferase 1A (liver)
CTGF connective tissue growth factor
CTNND1 catenin (cadherin-associated protein), delta 1
DEPTOR DEP domain containing MTOR-interacting protein
DHRS3 dehydrogenase/reductase (SDR family) member 3
DKK3 dickkopf WNT signaling pathway inhibitor 3
DUSP6 dual specificity phosphatase 6
EFHD1 EF-hand domain family, member D1
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB4 erb-b2 receptor tyrosine kinase 4
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FABP1 fatty acid binding protein 1, liver
FABP4 fatty acid binding protein 4, adipocyte
FAM69A family with sequence similarity 69, member A
FCGBP Fc fragment of IgG binding protein
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FHL1 four and a half LIM domains 1
FNBP1 formin binding protein 1
FOXO4 forkhead box O4
GAS6 growth arrest-specific 6
GSDMB gasdermin B
GSN gelsolin
HBP1 HMG-box transcription factor 1
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HOXD1 homeobox D1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
IL1R1 interleukin 1 receptor, type I
INA internexin neuronal intermediate filament protein, alpha
INSR insulin receptor
IRS1 insulin receptor substrate 1
ISYNA1 inositol-3-phosphate synthase 1
KRT20 keratin 20, type I
LGALS8 lectin, galactoside-binding, soluble, 8
LINC00341 long intergenic non-protein coding RNA 341
LPAR6 lysophosphatidic acid receptor 6
MVP major vault protein
MYO1D myosin ID
NFASC neurofascin
NT5E 5'-nucleotidase, ecto (CD73)
OLFM4 olfactomedin 4
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PRSS23 protease, serine, 23
RFTN1 raftlin, lipid raft linker 1
RGCC regulator of cell cycle
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCGB2A2 secretoglobin, family 2A, member 2
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SERINC5 serine incorporator 5
SGCE sarcoglycan, epsilon
SLC14A1 solute carrier family 14 (urea transporter), member 1 (Kidd blood group)
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC38A1 solute carrier family 38, member 1
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
STMN2 stathmin 2
STON1 stonin 1
STS steroid sulfatase (microsomal), isozyme S
TMEM35 transmembrane protein 35
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TNS3 tensin 3
TOX thymocyte selection-associated high mobility group box
TPP1 tripeptidyl peptidase I
TRPS1 trichorhinophalangeal syndrome I
TSPAN7 tetraspanin 7
TXNIP thioredoxin interacting protein
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VNN1 vanin 1
WFDC1 WAP four-disulfide core domain 1
WLS wntless Wnt ligand secretion mediator
YIPF3 Yip1 domain family, member 3
YPEL5 yippee-like 5 (Drosophila)
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1
AK1 adenylate kinase 1
AK4 adenylate kinase 4
APITD1 apoptosis-inducing, TAF9-like domain 1
ASF1B anti-silencing function 1B histone chaperone
AURKA aurora kinase A
BIRC5 baculoviral IAP repeat containing 5
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CCNA2 cyclin A2
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CENPU centromere protein U
CKS2 CDC28 protein kinase regulatory subunit 2
CSE1L CSE1 chromosome segregation 1-like (yeast)
CTPS1 CTP synthase 1
CXCL8 chemokine (C-X-C motif) ligand 8
CYB5A cytochrome b5 type A (microsomal)
DBF4 DBF4 zinc finger
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP14 dual specificity phosphatase 14
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
EIF4E eukaryotic translation initiation factor 4E
EIF5A eukaryotic translation initiation factor 5A
ELAVL1 ELAV like RNA binding protein 1
EMP3 epithelial membrane protein 3
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FEN1 flap structure-specific endonuclease 1
FOSL1 FOS-like antigen 1
FOXM1 forkhead box M1
GGCT gamma-glutamylcyclotransferase
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
H2AFX H2A histone family, member X
HN1 hematological and neurological expressed 1
HSPA14 heat shock 70kDa protein 14
IGFBP3 insulin-like growth factor binding protein 3
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
KIF14 kinesin family member 14
KIF20A kinesin family member 20A
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRT10 keratin 10, type I
LPL lipoprotein lipase
LRRC59 leucine rich repeat containing 59
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LTF lactotransferrin
MCM10 minichromosome maintenance complex component 10
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MRPS7 mitochondrial ribosomal protein S7
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NME1 NME/NM23 nucleoside diphosphate kinase 1
NUP85 nucleoporin 85kDa
NUP98 nucleoporin 98kDa
NUPL1 nucleoporin like 1
ODC1 ornithine decarboxylase 1
PARP2 poly (ADP-ribose) polymerase 2
PBK PDZ binding kinase
PFKP phosphofructokinase, platelet
PGC progastricsin (pepsinogen C)
PITX1 paired-like homeodomain 1
PLK1 polo-like kinase 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
POLA2 polymerase (DNA directed), alpha 2, accessory subunit
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRC1 protein regulator of cytokinesis 1
QDPR quinoid dihydropteridine reductase
RAE1 ribonucleic acid export 1
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RPP40 ribonuclease P/MRP 40kDa subunit
SACS sacsin molecular chaperone
SFN stratifin
SHCBP1 SHC SH2-domain binding protein 1
SMC4 structural maintenance of chromosomes 4
SNRPF small nuclear ribonucleoprotein polypeptide F
SNRPG small nuclear ribonucleoprotein polypeptide G
SRM spermidine synthase
SRSF3 serine/arginine-rich splicing factor 3
SRSF7 serine/arginine-rich splicing factor 7
STMN1 stathmin 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC3 transforming, acidic coiled-coil containing protein 3
TDP1 tyrosyl-DNA phosphodiesterase 1
TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast)
TIPIN TIMELESS interacting protein
TMPO thymopoietin
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TPX2 TPX2, microtubule-associated
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UGCG UDP-glucose ceramide glucosyltransferase
WBSCR22 Williams Beuren syndrome chromosome region 22