BRD-K52850071_JAK3 Inhibitor II_PC3_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

80 genes differentially expressed following the BRD-K52850071_JAK3 Inhibitor II_PC3_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
BEX1 brain expressed, X-linked 1
C10ORF10 chromosome 10 open reading frame 10
CA2 carbonic anhydrase II
CCP110 centriolar coiled coil protein 110kDa
CD36 CD36 molecule (thrombospondin receptor)
CD40 CD40 molecule, TNF receptor superfamily member 5
COL4A5 collagen, type IV, alpha 5
CPA3 carboxypeptidase A3 (mast cell)
CRABP2 cellular retinoic acid binding protein 2
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
DHRS1 dehydrogenase/reductase (SDR family) member 1
FRY furry homolog (Drosophila)
GALC galactosylceramidase
GUSBP11 glucuronidase, beta pseudogene 11
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
IGLV2-23 immunoglobulin lambda variable 2-23
IGLV3-19 immunoglobulin lambda variable 3-19
JCHAIN joining chain of multimeric IgA and IgM
LDOC1 leucine zipper, down-regulated in cancer 1
LYN LYN proto-oncogene, Src family tyrosine kinase
PHGDH phosphoglycerate dehydrogenase
PYCARD PYD and CARD domain containing
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
RTN1 reticulon 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SFRP1 secreted frizzled-related protein 1
SFTPB surfactant protein B
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TFF3 trefoil factor 3 (intestinal)
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TRIB3 tribbles pseudokinase 3
TXNIP thioredoxin interacting protein
WARS tryptophanyl-tRNA synthetase

decreased expression

Symbol Name
ATF3 activating transcription factor 3
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
BAG2 BCL2-associated athanogene 2
BCAT1 branched chain amino-acid transaminase 1, cytosolic
BCL2A1 BCL2-related protein A1
CCNG1 cyclin G1
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CENPN centromere protein N
CHEK1 checkpoint kinase 1
CHPT1 choline phosphotransferase 1
CRISP3 cysteine-rich secretory protein 3
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CXCL5 chemokine (C-X-C motif) ligand 5
CYCS cytochrome c, somatic
DARS aspartyl-tRNA synthetase
EIF4B eukaryotic translation initiation factor 4B
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GLDC glycine dehydrogenase (decarboxylating)
HOMER1 homer scaffolding protein 1
IGFBP3 insulin-like growth factor binding protein 3
LAMC2 laminin, gamma 2
LYPLA1 lysophospholipase I
MREG melanoregulin
MXRA7 matrix-remodelling associated 7
NCK2 NCK adaptor protein 2
NIP7 NIP7, nucleolar pre-rRNA processing protein
PEBP1 phosphatidylethanolamine binding protein 1
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
RRAGD Ras-related GTP binding D
SAMD4A sterile alpha motif domain containing 4A
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLPI secretory leukocyte peptidase inhibitor
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TYRP1 tyrosinase-related protein 1
XPO7 exportin 7
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon