| Dataset | LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map) |
| Similar Terms | |
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228 genes differentially expressed following the BRD-K52850071_JAK3 Inhibitor II_HCC515_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
| Symbol | Name |
|---|---|
| 1060P11.3 | killer cell immunoglobulin-like receptor, three domains, pseudogene |
| AARS | alanyl-tRNA synthetase |
| AKR1C1 | aldo-keto reductase family 1, member C1 |
| AKR1C2 | aldo-keto reductase family 1, member C2 |
| AKR1C3 | aldo-keto reductase family 1, member C3 |
| ALDH2 | aldehyde dehydrogenase 2 family (mitochondrial) |
| ANXA11 | annexin A11 |
| ANXA4 | annexin A4 |
| APOC1 | apolipoprotein C-I |
| ARHGAP29 | Rho GTPase activating protein 29 |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) |
| ASPN | asporin |
| ASS1 | argininosuccinate synthase 1 |
| ATF4 | activating transcription factor 4 |
| BEX4 | brain expressed, X-linked 4 |
| BLVRB | biliverdin reductase B |
| C10ORF10 | chromosome 10 open reading frame 10 |
| C3 | complement component 3 |
| CAMK2N1 | calcium/calmodulin-dependent protein kinase II inhibitor 1 |
| CARS | cysteinyl-tRNA synthetase |
| CCNG2 | cyclin G2 |
| CD24 | CD24 molecule |
| CDH1 | cadherin 1, type 1, E-cadherin (epithelial) |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) |
| CFD | complement factor D (adipsin) |
| CHAC1 | ChaC glutathione-specific gamma-glutamylcyclotransferase 1 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 |
| CREG1 | cellular repressor of E1A-stimulated genes 1 |
| CTH | cystathionine gamma-lyase |
| DDIT3 | DNA-damage-inducible transcript 3 |
| DNAJB9 | DnaJ (Hsp40) homolog, subfamily B, member 9 |
| DPP4 | dipeptidyl-peptidase 4 |
| EPCAM | epithelial cell adhesion molecule |
| EPRS | glutamyl-prolyl-tRNA synthetase |
| FABP4 | fatty acid binding protein 4, adipocyte |
| FBLN1 | fibulin 1 |
| FGG | fibrinogen gamma chain |
| FOLH1 | folate hydrolase (prostate-specific membrane antigen) 1 |
| FTH1 | ferritin, heavy polypeptide 1 |
| GABRP | gamma-aminobutyric acid (GABA) A receptor, pi |
| GCLM | glutamate-cysteine ligase, modifier subunit |
| GLRX | glutaredoxin (thioltransferase) |
| GRN | granulin |
| GSTM3 | glutathione S-transferase mu 3 (brain) |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 |
| HHEX | hematopoietically expressed homeobox |
| HIST1H2AC | histone cluster 1, H2ac |
| HIST1H2BD | histone cluster 1, H2bd |
| HLA-DMB | major histocompatibility complex, class II, DM beta |
| HMOX1 | heme oxygenase 1 |
| HSPG2 | heparan sulfate proteoglycan 2 |
| ID4 | inhibitor of DNA binding 4, dominant negative helix-loop-helix protein |
| IGKV4-1 | immunoglobulin kappa variable 4-1 |
| IRS2 | insulin receptor substrate 2 |
| JAG1 | jagged 1 |
| KRT19 | keratin 19, type I |
| LAMP2 | lysosomal-associated membrane protein 2 |
| LCN2 | lipocalin 2 |
| LDOC1 | leucine zipper, down-regulated in cancer 1 |
| LINC00341 | long intergenic non-protein coding RNA 341 |
| LRRC8D | leucine rich repeat containing 8 family, member D |
| MAOA | monoamine oxidase A |
| MARS | methionyl-tRNA synthetase |
| MME | membrane metallo-endopeptidase |
| MMP7 | matrix metallopeptidase 7 |
| MS4A3 | membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific) |
| MSMB | microseminoprotein, beta- |
| NUPR1 | nuclear protein, transcriptional regulator, 1 |
| OLFML2A | olfactomedin-like 2A |
| P2RX1 | purinergic receptor P2X, ligand gated ion channel, 1 |
| PCK2 | phosphoenolpyruvate carboxykinase 2 (mitochondrial) |
| PDGFD | platelet derived growth factor D |
| PDZK1IP1 | PDZK1 interacting protein 1 |
| PEG10 | paternally expressed 10 |
| PRSS8 | protease, serine, 8 |
| PSAT1 | phosphoserine aminotransferase 1 |
| PSMF1 | proteasome (prosome, macropain) inhibitor subunit 1 (PI31) |
| PXDN | peroxidasin |
| PYCARD | PYD and CARD domain containing |
| RGCC | regulator of cell cycle |
| RSRP1 | arginine/serine-rich protein 1 |
| RTN1 | reticulon 1 |
| S100A8 | S100 calcium binding protein A8 |
| S100P | S100 calcium binding protein P |
| SARS | seryl-tRNA synthetase |
| SCNN1A | sodium channel, non voltage gated 1 alpha subunit |
| SCPEP1 | serine carboxypeptidase 1 |
| SERPINF1 | serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 |
| SLC38A2 | solute carrier family 38, member 2 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 |
| SPON2 | spondin 2, extracellular matrix protein |
| STC2 | stanniocalcin 2 |
| TACSTD2 | tumor-associated calcium signal transducer 2 |
| TMEM230 | transmembrane protein 230 |
| TPD52L1 | tumor protein D52-like 1 |
| TPP1 | tripeptidyl peptidase I |
| TRIB3 | tribbles pseudokinase 3 |
| TSC22D3 | TSC22 domain family, member 3 |
| TXNIP | thioredoxin interacting protein |
| TXNRD1 | thioredoxin reductase 1 |
| UBE2C | ubiquitin-conjugating enzyme E2C |
| VAMP1 | vesicle-associated membrane protein 1 (synaptobrevin 1) |
| VPS28 | vacuolar protein sorting 28 homolog (S. cerevisiae) |
| VTCN1 | V-set domain containing T cell activation inhibitor 1 |
| XBP1 | X-box binding protein 1 |
| XIST | X inactive specific transcript (non-protein coding) |
| YPEL5 | yippee-like 5 (Drosophila) |
| Symbol | Name |
|---|---|
| ABHD2 | abhydrolase domain containing 2 |
| AQP3 | aquaporin 3 (Gill blood group) |
| ASF1B | anti-silencing function 1B histone chaperone |
| ATP6V0E1 | ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1 |
| AURKA | aurora kinase A |
| AUTS2 | autism susceptibility candidate 2 |
| BLM | Bloom syndrome, RecQ helicase-like |
| BRCA1 | breast cancer 1, early onset |
| BST2 | bone marrow stromal cell antigen 2 |
| CADM1 | cell adhesion molecule 1 |
| CCL2 | chemokine (C-C motif) ligand 2 |
| CCNA2 | cyclin A2 |
| CCND1 | cyclin D1 |
| CCNE2 | cyclin E2 |
| CCNF | cyclin F |
| CD59 | CD59 molecule, complement regulatory protein |
| CDC42 | cell division cycle 42 |
| CDC45 | cell division cycle 45 |
| CDC6 | cell division cycle 6 |
| CDH2 | cadherin 2, type 1, N-cadherin (neuronal) |
| CDKN1B | cyclin-dependent kinase inhibitor 1B (p27, Kip1) |
| CERS6 | ceramide synthase 6 |
| COCH | cochlin |
| CTTN | cortactin |
| CXCL14 | chemokine (C-X-C motif) ligand 14 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 |
| DBF4 | DBF4 zinc finger |
| DTL | denticleless E3 ubiquitin protein ligase homolog (Drosophila) |
| DUSP6 | dual specificity phosphatase 6 |
| EGFR | epidermal growth factor receptor |
| EIF5A | eukaryotic translation initiation factor 5A |
| ENC1 | ectodermal-neural cortex 1 (with BTB domain) |
| ENO1 | enolase 1, (alpha) |
| EPHB2 | EPH receptor B2 |
| EPN2 | epsin 2 |
| EREG | epiregulin |
| EXO1 | exonuclease 1 |
| EXOSC2 | exosome component 2 |
| FABP5 | fatty acid binding protein 5 (psoriasis-associated) |
| FANCI | Fanconi anemia, complementation group I |
| FEN1 | flap structure-specific endonuclease 1 |
| FGFR3 | fibroblast growth factor receptor 3 |
| FOLR1 | folate receptor 1 (adult) |
| FOSL1 | FOS-like antigen 1 |
| GALNT2 | polypeptide N-acetylgalactosaminyltransferase 2 |
| GINS2 | GINS complex subunit 2 (Psf2 homolog) |
| GPM6B | glycoprotein M6B |
| GTSE1 | G-2 and S-phase expressed 1 |
| HELLS | helicase, lymphoid-specific |
| HERC5 | HECT and RLD domain containing E3 ubiquitin protein ligase 5 |
| HOPX | HOP homeobox |
| HP | haptoglobin |
| HPRT1 | hypoxanthine phosphoribosyltransferase 1 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) |
| HSPE1 | heat shock 10kDa protein 1 |
| IER3 | immediate early response 3 |
| ITM2A | integral membrane protein 2A |
| KIAA0101 | KIAA0101 |
| KIAA0125 | KIAA0125 |
| KIF14 | kinesin family member 14 |
| KIF18B | kinesin family member 18B |
| LAGE3 | L antigen family, member 3 |
| LAMC2 | laminin, gamma 2 |
| LIG1 | ligase I, DNA, ATP-dependent |
| MARCKS | myristoylated alanine-rich protein kinase C substrate |
| MCM10 | minichromosome maintenance complex component 10 |
| MCM3 | minichromosome maintenance complex component 3 |
| MCM4 | minichromosome maintenance complex component 4 |
| MCM5 | minichromosome maintenance complex component 5 |
| MCM6 | minichromosome maintenance complex component 6 |
| MKI67 | marker of proliferation Ki-67 |
| MYBL2 | v-myb avian myeloblastosis viral oncogene homolog-like 2 |
| NETO2 | neuropilin (NRP) and tolloid (TLL)-like 2 |
| NFIB | nuclear factor I/B |
| NOLC1 | nucleolar and coiled-body phosphoprotein 1 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 |
| NUP62 | nucleoporin 62kDa |
| OLFM1 | olfactomedin 1 |
| PAICS | phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase |
| PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 |
| PFKP | phosphofructokinase, platelet |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 |
| PIK3R1 | phosphoinositide-3-kinase, regulatory subunit 1 (alpha) |
| PKM | pyruvate kinase, muscle |
| PLK1 | polo-like kinase 1 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 |
| POLA2 | polymerase (DNA directed), alpha 2, accessory subunit |
| PPIF | peptidylprolyl isomerase F |
| PRPS2 | phosphoribosyl pyrophosphate synthetase 2 |
| PRR7 | proline rich 7 (synaptic) |
| PSMC3IP | PSMC3 interacting protein |
| PTMA | prothymosin, alpha |
| RFC2 | replication factor C (activator 1) 2, 40kDa |
| RGS2 | regulator of G-protein signaling 2 |
| RPL27A | ribosomal protein L27a |
| RPL37A | ribosomal protein L37a |
| RPL38 | ribosomal protein L38 |
| RPS11 | ribosomal protein S11 |
| RRM1 | ribonucleotide reductase M1 |
| RRM2 | ribonucleotide reductase M2 |
| S100A2 | S100 calcium binding protein A2 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C |
| SET | SET nuclear proto-oncogene |
| SHCBP1 | SHC SH2-domain binding protein 1 |
| SLC39A8 | solute carrier family 39 (zinc transporter), member 8 |
| SLIRP | SRA stem-loop interacting RNA binding protein |
| SPAG5 | sperm associated antigen 5 |
| SPRR3 | small proline-rich protein 3 |
| SPRY2 | sprouty homolog 2 (Drosophila) |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) |
| SUV39H1 | suppressor of variegation 3-9 homolog 1 (Drosophila) |
| SYNE1 | spectrin repeat containing, nuclear envelope 1 |
| TIPIN | TIMELESS interacting protein |
| TRIP13 | thyroid hormone receptor interactor 13 |
| TSTA3 | tissue specific transplantation antigen P35B |
| TUBA4A | tubulin, alpha 4a |
| TYRP1 | tyrosinase-related protein 1 |
| VCAN | versican |
| XPO7 | exportin 7 |
