BRD-K52850071_JAK3 Inhibitor II_HCC515_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

228 genes differentially expressed following the BRD-K52850071_JAK3 Inhibitor II_HCC515_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ANXA11 annexin A11
ANXA4 annexin A4
APOC1 apolipoprotein C-I
ARHGAP29 Rho GTPase activating protein 29
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASPN asporin
ASS1 argininosuccinate synthase 1
ATF4 activating transcription factor 4
BEX4 brain expressed, X-linked 4
BLVRB biliverdin reductase B
C10ORF10 chromosome 10 open reading frame 10
C3 complement component 3
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CARS cysteinyl-tRNA synthetase
CCNG2 cyclin G2
CD24 CD24 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CFD complement factor D (adipsin)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CREG1 cellular repressor of E1A-stimulated genes 1
CTH cystathionine gamma-lyase
DDIT3 DNA-damage-inducible transcript 3
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DPP4 dipeptidyl-peptidase 4
EPCAM epithelial cell adhesion molecule
EPRS glutamyl-prolyl-tRNA synthetase
FABP4 fatty acid binding protein 4, adipocyte
FBLN1 fibulin 1
FGG fibrinogen gamma chain
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1
FTH1 ferritin, heavy polypeptide 1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GCLM glutamate-cysteine ligase, modifier subunit
GLRX glutaredoxin (thioltransferase)
GRN granulin
GSTM3 glutathione S-transferase mu 3 (brain)
GULP1 GULP, engulfment adaptor PTB domain containing 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HHEX hematopoietically expressed homeobox
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HLA-DMB major histocompatibility complex, class II, DM beta
HMOX1 heme oxygenase 1
HSPG2 heparan sulfate proteoglycan 2
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IGKV4-1 immunoglobulin kappa variable 4-1
IRS2 insulin receptor substrate 2
JAG1 jagged 1
KRT19 keratin 19, type I
LAMP2 lysosomal-associated membrane protein 2
LCN2 lipocalin 2
LDOC1 leucine zipper, down-regulated in cancer 1
LINC00341 long intergenic non-protein coding RNA 341
LRRC8D leucine rich repeat containing 8 family, member D
MAOA monoamine oxidase A
MARS methionyl-tRNA synthetase
MME membrane metallo-endopeptidase
MMP7 matrix metallopeptidase 7
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
MSMB microseminoprotein, beta-
NUPR1 nuclear protein, transcriptional regulator, 1
OLFML2A olfactomedin-like 2A
P2RX1 purinergic receptor P2X, ligand gated ion channel, 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDGFD platelet derived growth factor D
PDZK1IP1 PDZK1 interacting protein 1
PEG10 paternally expressed 10
PRSS8 protease, serine, 8
PSAT1 phosphoserine aminotransferase 1
PSMF1 proteasome (prosome, macropain) inhibitor subunit 1 (PI31)
PXDN peroxidasin
PYCARD PYD and CARD domain containing
RGCC regulator of cell cycle
RSRP1 arginine/serine-rich protein 1
RTN1 reticulon 1
S100A8 S100 calcium binding protein A8
S100P S100 calcium binding protein P
SARS seryl-tRNA synthetase
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SCPEP1 serine carboxypeptidase 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLC38A2 solute carrier family 38, member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPON2 spondin 2, extracellular matrix protein
STC2 stanniocalcin 2
TACSTD2 tumor-associated calcium signal transducer 2
TMEM230 transmembrane protein 230
TPD52L1 tumor protein D52-like 1
TPP1 tripeptidyl peptidase I
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
TXNRD1 thioredoxin reductase 1
UBE2C ubiquitin-conjugating enzyme E2C
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae)
VTCN1 V-set domain containing T cell activation inhibitor 1
XBP1 X-box binding protein 1
XIST X inactive specific transcript (non-protein coding)
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
ABHD2 abhydrolase domain containing 2
AQP3 aquaporin 3 (Gill blood group)
ASF1B anti-silencing function 1B histone chaperone
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
AURKA aurora kinase A
AUTS2 autism susceptibility candidate 2
BLM Bloom syndrome, RecQ helicase-like
BRCA1 breast cancer 1, early onset
BST2 bone marrow stromal cell antigen 2
CADM1 cell adhesion molecule 1
CCL2 chemokine (C-C motif) ligand 2
CCNA2 cyclin A2
CCND1 cyclin D1
CCNE2 cyclin E2
CCNF cyclin F
CD59 CD59 molecule, complement regulatory protein
CDC42 cell division cycle 42
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CERS6 ceramide synthase 6
COCH cochlin
CTTN cortactin
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL8 chemokine (C-X-C motif) ligand 8
DBF4 DBF4 zinc finger
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP6 dual specificity phosphatase 6
EGFR epidermal growth factor receptor
EIF5A eukaryotic translation initiation factor 5A
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ENO1 enolase 1, (alpha)
EPHB2 EPH receptor B2
EPN2 epsin 2
EREG epiregulin
EXO1 exonuclease 1
EXOSC2 exosome component 2
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FANCI Fanconi anemia, complementation group I
FEN1 flap structure-specific endonuclease 1
FGFR3 fibroblast growth factor receptor 3
FOLR1 folate receptor 1 (adult)
FOSL1 FOS-like antigen 1
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2
GINS2 GINS complex subunit 2 (Psf2 homolog)
GPM6B glycoprotein M6B
GTSE1 G-2 and S-phase expressed 1
HELLS helicase, lymphoid-specific
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HOPX HOP homeobox
HP haptoglobin
HPRT1 hypoxanthine phosphoribosyltransferase 1
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPE1 heat shock 10kDa protein 1
IER3 immediate early response 3
ITM2A integral membrane protein 2A
KIAA0101 KIAA0101
KIAA0125 KIAA0125
KIF14 kinesin family member 14
KIF18B kinesin family member 18B
LAGE3 L antigen family, member 3
LAMC2 laminin, gamma 2
LIG1 ligase I, DNA, ATP-dependent
MARCKS myristoylated alanine-rich protein kinase C substrate
MCM10 minichromosome maintenance complex component 10
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MKI67 marker of proliferation Ki-67
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NFIB nuclear factor I/B
NOLC1 nucleolar and coiled-body phosphoprotein 1
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1
NUP62 nucleoporin 62kDa
OLFM1 olfactomedin 1
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PFKP phosphofructokinase, platelet
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PKM pyruvate kinase, muscle
PLK1 polo-like kinase 1
PMEPA1 prostate transmembrane protein, androgen induced 1
POLA2 polymerase (DNA directed), alpha 2, accessory subunit
PPIF peptidylprolyl isomerase F
PRPS2 phosphoribosyl pyrophosphate synthetase 2
PRR7 proline rich 7 (synaptic)
PSMC3IP PSMC3 interacting protein
PTMA prothymosin, alpha
RFC2 replication factor C (activator 1) 2, 40kDa
RGS2 regulator of G-protein signaling 2
RPL27A ribosomal protein L27a
RPL37A ribosomal protein L37a
RPL38 ribosomal protein L38
RPS11 ribosomal protein S11
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
S100A2 S100 calcium binding protein A2
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SET SET nuclear proto-oncogene
SHCBP1 SHC SH2-domain binding protein 1
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLIRP SRA stem-loop interacting RNA binding protein
SPAG5 sperm associated antigen 5
SPRR3 small proline-rich protein 3
SPRY2 sprouty homolog 2 (Drosophila)
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SYNE1 spectrin repeat containing, nuclear envelope 1
TIPIN TIMELESS interacting protein
TRIP13 thyroid hormone receptor interactor 13
TSTA3 tissue specific transplantation antigen P35B
TUBA4A tubulin, alpha 4a
TYRP1 tyrosinase-related protein 1
VCAN versican
XPO7 exportin 7