BRD-K52850071_JAK3 Inhibitor II_HA1E_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

110 genes differentially expressed following the BRD-K52850071_JAK3 Inhibitor II_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ACOT13 acyl-CoA thioesterase 13
AIM2 absent in melanoma 2
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASPN asporin
BCL6 B-cell CLL/lymphoma 6
C10ORF10 chromosome 10 open reading frame 10
C1QB complement component 1, q subcomponent, B chain
CA2 carbonic anhydrase II
CAT catalase
CBS cystathionine-beta-synthase
CD14 CD14 molecule
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CPA3 carboxypeptidase A3 (mast cell)
ECI1 enoyl-CoA delta isomerase 1
ENO2 enolase 2 (gamma, neuronal)
FBN2 fibrillin 2
FLOT1 flotillin 1
GCLC glutamate-cysteine ligase, catalytic subunit
GLUL glutamate-ammonia ligase
GUSB glucuronidase, beta
GUSBP11 glucuronidase, beta pseudogene 11
IFNAR1 interferon (alpha, beta and omega) receptor 1
IGHM immunoglobulin heavy constant mu
IGLV2-23 immunoglobulin lambda variable 2-23
LGALS8 lectin, galactoside-binding, soluble, 8
MAOA monoamine oxidase A
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
MARS methionyl-tRNA synthetase
MEX3D mex-3 RNA binding family member D
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NGRN neugrin, neurite outgrowth associated
NUPR1 nuclear protein, transcriptional regulator, 1
NVL nuclear VCP-like
PHGDH phosphoglycerate dehydrogenase
PSMF1 proteasome (prosome, macropain) inhibitor subunit 1 (PI31)
RGCC regulator of cell cycle
RGS2 regulator of G-protein signaling 2
SEPP1 selenoprotein P, plasma, 1
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
TPD52L1 tumor protein D52-like 1
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
VEGFA vascular endothelial growth factor A
VTCN1 V-set domain containing T cell activation inhibitor 1
WARS tryptophanyl-tRNA synthetase

decreased expression

Symbol Name
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANXA5 annexin A5
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
CBFB core-binding factor, beta subunit
CBR3 carbonyl reductase 3
CCND1 cyclin D1
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CHL1 cell adhesion molecule L1-like
CLDN10 claudin 10
COL1A1 collagen, type I, alpha 1
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CXCL8 chemokine (C-X-C motif) ligand 8
CYCS cytochrome c, somatic
DEFB1 defensin, beta 1
DLC1 DLC1 Rho GTPase activating protein
DLK1 delta-like 1 homolog (Drosophila)
EBP emopamil binding protein (sterol isomerase)
EGR3 early growth response 3
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM98A family with sequence similarity 98, member A
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GLIPR1 GLI pathogenesis-related 1
HN1 hematological and neurological expressed 1
HOMER1 homer scaffolding protein 1
HSPA8 heat shock 70kDa protein 8
IL6ST interleukin 6 signal transducer
KRT10 keratin 10, type I
MOK MOK protein kinase
NOLC1 nucleolar and coiled-body phosphoprotein 1
PDLIM4 PDZ and LIM domain 4
PON2 paraoxonase 2
PPIF peptidylprolyl isomerase F
PRPS2 phosphoribosyl pyrophosphate synthetase 2
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTGES prostaglandin E synthase
PTMA prothymosin, alpha
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RPL27A ribosomal protein L27a
RPL37A ribosomal protein L37a
RPL38 ribosomal protein L38
RPS11 ribosomal protein S11
S100A2 S100 calcium binding protein A2
SFN stratifin
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SRPRB signal recognition particle receptor, B subunit
SRPX sushi-repeat containing protein, X-linked
STOM stomatin
TMF1 TATA element modulatory factor 1
TSPAN8 tetraspanin 8
UBE2E3 ubiquitin-conjugating enzyme E2E 3
UGCG UDP-glucose ceramide glucosyltransferase
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta