BRD-K52850071_JAK3 Inhibitor II_HA1E_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

115 genes differentially expressed following the BRD-K52850071_JAK3 Inhibitor II_HA1E_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AIM2 absent in melanoma 2
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
APOBEC3A apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A
ASNS asparagine synthetase (glutamine-hydrolyzing)
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CASC3 cancer susceptibility candidate 3
CD14 CD14 molecule
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CLCA1 chloride channel accessory 1
CYBB cytochrome b-245, beta polypeptide
DUSP14 dual specificity phosphatase 14
EMX2 empty spiracles homeobox 2
EZR ezrin
FCN1 ficolin (collagen/fibrinogen domain containing) 1
FGR FGR proto-oncogene, Src family tyrosine kinase
GATA3 GATA binding protein 3
GCLC glutamate-cysteine ligase, catalytic subunit
GNLY granulysin
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
GZMH granzyme H (cathepsin G-like 2, protein h-CCPX)
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DRA major histocompatibility complex, class II, DR alpha
IKZF1 IKAROS family zinc finger 1 (Ikaros)
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KRT13 keratin 13, type I
KRT15 keratin 15, type I
MTSS1 metastasis suppressor 1
NARFL nuclear prelamin A recognition factor-like
NELL2 NEL-like 2 (chicken)
NNT nicotinamide nucleotide transhydrogenase
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
RAB27A RAB27A, member RAS oncogene family
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SLAMF7 SLAM family member 7
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOX11 SRY (sex determining region Y)-box 11
STK10 serine/threonine kinase 10
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TXNIP thioredoxin interacting protein
WFDC2 WAP four-disulfide core domain 2
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ADI1 acireductone dioxygenase 1
AK4 adenylate kinase 4
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALDOA aldolase A, fructose-bisphosphate
ALG5 ALG5, dolichyl-phosphate beta-glucosyltransferase
ANPEP alanyl (membrane) aminopeptidase
ASPN asporin
BST2 bone marrow stromal cell antigen 2
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast)
CD44 CD44 molecule (Indian blood group)
CDC20 cell division cycle 20
CLEC11A C-type lectin domain family 11, member A
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL14 chemokine (C-X-C motif) ligand 14
CYCS cytochrome c, somatic
DARS aspartyl-tRNA synthetase
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DHCR24 24-dehydrocholesterol reductase
DLC1 DLC1 Rho GTPase activating protein
DPYSL3 dihydropyrimidinase-like 3
DUSP22 dual specificity phosphatase 22
DUSP3 dual specificity phosphatase 3
EBP emopamil binding protein (sterol isomerase)
ELF1 E74-like factor 1 (ets domain transcription factor)
FAM162A family with sequence similarity 162, member A
FDFT1 farnesyl-diphosphate farnesyltransferase 1
GNAS GNAS complex locus
GOLGA8A golgin A8 family, member A
GOLT1B golgi transport 1B
HN1 hematological and neurological expressed 1
HOXC6 homeobox C6
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IGF1R insulin-like growth factor 1 receptor
IL1R1 interleukin 1 receptor, type I
INSIG1 insulin induced gene 1
ISG15 ISG15 ubiquitin-like modifier
LDLR low density lipoprotein receptor
MAB21L2 mab-21-like 2 (C. elegans)
MOK MOK protein kinase
MSMO1 methylsterol monooxygenase 1
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1M metallothionein 1M
MT1X metallothionein 1X
OGN osteoglycin
PDGFC platelet derived growth factor C
PKM pyruvate kinase, muscle
PLAGL1 pleiomorphic adenoma gene-like 1
PLS3 plastin 3
PRPS2 phosphoribosyl pyrophosphate synthetase 2
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFRP1 secreted frizzled-related protein 1
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC43A3 solute carrier family 43, member 3
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPINK1 serine peptidase inhibitor, Kazal type 1
SRPX sushi-repeat containing protein, X-linked
TFRC transferrin receptor
THBS2 thrombospondin 2
TNIP1 TNFAIP3 interacting protein 1
TSPAN4 tetraspanin 4
VCAN versican
VDAC1 voltage-dependent anion channel 1
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble