BRD-K52075040_-666_NCIH508_6.0_h_44.4_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

181 genes differentially expressed following the BRD-K52075040_-666_NCIH508_6.0_h_44.4_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANXA1 annexin A1
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
BEX1 brain expressed, X-linked 1
BTG2 BTG family, member 2
CA2 carbonic anhydrase II
CADM1 cell adhesion molecule 1
CALML3 calmodulin-like 3
CD163 CD163 molecule
CD9 CD9 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEP57 centrosomal protein 57kDa
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLEC11A C-type lectin domain family 11, member A
COL6A2 collagen, type VI, alpha 2
COL8A2 collagen, type VIII, alpha 2
COMP cartilage oligomeric matrix protein
CPA3 carboxypeptidase A3 (mast cell)
CRELD2 cysteine-rich with EGF-like domains 2
CSRP2 cysteine and glycine-rich protein 2
DDIT4 DNA-damage-inducible transcript 4
DKK3 dickkopf WNT signaling pathway inhibitor 3
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DPYSL3 dihydropyrimidinase-like 3
DSP desmoplakin
DSTN destrin (actin depolymerizing factor)
DUSP1 dual specificity phosphatase 1
DUSP2 dual specificity phosphatase 2
EGR1 early growth response 1
EZR ezrin
FAM129A family with sequence similarity 129, member A
FGFBP1 fibroblast growth factor binding protein 1
FGFR3 fibroblast growth factor receptor 3
FN1 fibronectin 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FST follistatin
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GAS6 growth arrest-specific 6
GLUL glutamate-ammonia ligase
GUSBP11 glucuronidase, beta pseudogene 11
HMOX1 heme oxygenase 1
HP haptoglobin
HSPA2 heat shock 70kDa protein 2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
IER3 immediate early response 3
IER5 immediate early response 5
IGFBP7 insulin-like growth factor binding protein 7
IGHM immunoglobulin heavy constant mu
IL1R1 interleukin 1 receptor, type I
INHBA inhibin, beta A
ITM2C integral membrane protein 2C
JUN jun proto-oncogene
KRT16 keratin 16, type I
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
LAMA3 laminin, alpha 3
LDLR low density lipoprotein receptor
LOC100505650 uncharacterized LOC100505650
LOXL2 lysyl oxidase-like 2
LRRC15 leucine rich repeat containing 15
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAN2A1 mannosidase, alpha, class 2A, member 1
MMP1 matrix metallopeptidase 1
MMP11 matrix metallopeptidase 11
MOK MOK protein kinase
NELL2 NEL-like 2 (chicken)
NR4A1 nuclear receptor subfamily 4, group A, member 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PKP1 plakophilin 1
PLAU plasminogen activator, urokinase
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RBP1 retinol binding protein 1, cellular
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RHOB ras homolog family member B
S100A2 S100 calcium binding protein A2
S100A7 S100 calcium binding protein A7
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFN stratifin
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
STC2 stanniocalcin 2
SULF1 sulfatase 1
THBS2 thrombospondin 2
THBS4 thrombospondin 4
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TPBG trophoblast glycoprotein
TRIB1 tribbles pseudokinase 1
TUBB2A tubulin, beta 2A class IIa
TUFT1 tuftelin 1
VEGFA vascular endothelial growth factor A
WBP5 WW domain binding protein 5
WISP2 WNT1 inducible signaling pathway protein 2
XIST X inactive specific transcript (non-protein coding)
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3
AGTR1 angiotensin II receptor, type 1
ANXA3 annexin A3
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
BST2 bone marrow stromal cell antigen 2
CCNB2 cyclin B2
CCND3 cyclin D3
CD24 CD24 molecule
CDC42 cell division cycle 42
CDK4 cyclin-dependent kinase 4
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CENPA centromere protein A
CHPT1 choline phosphotransferase 1
CLIC5 chloride intracellular channel 5
CRYAB crystallin, alpha B
CSK c-src tyrosine kinase
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL5 chemokine (C-X-C motif) ligand 5
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GGT1 gamma-glutamyltransferase 1
GTF3A general transcription factor IIIA
HBB hemoglobin, beta
HES1 hes family bHLH transcription factor 1
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HN1 hematological and neurological expressed 1
HOXA10 homeobox A10
HPRT1 hypoxanthine phosphoribosyltransferase 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KRT7 keratin 7, type II
LPCAT1 lysophosphatidylcholine acyltransferase 1
LPL lipoprotein lipase
LXN latexin
LY75 lymphocyte antigen 75
MARCKS myristoylated alanine-rich protein kinase C substrate
MET MET proto-oncogene, receptor tyrosine kinase
MPZL1 myelin protein zero-like 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NBN nibrin
NEBL nebulette
NFIB nuclear factor I/B
NPY1R neuropeptide Y receptor Y1
NR2F2 nuclear receptor subfamily 2, group F, member 2
OXTR oxytocin receptor
PEBP1 phosphatidylethanolamine binding protein 1
PIP prolactin-induced protein
PLAC8 placenta-specific 8
PLK1 polo-like kinase 1
PPAP2C phosphatidic acid phosphatase type 2C
PPARG peroxisome proliferator-activated receptor gamma
PROM1 prominin 1
PRPF4 pre-mRNA processing factor 4
PRPS2 phosphoribosyl pyrophosphate synthetase 2
PSD3 pleckstrin and Sec7 domain containing 3
PTP4A2 protein tyrosine phosphatase type IVA, member 2
RBM47 RNA binding motif protein 47
RPS11 ribosomal protein S11
SESN1 sestrin 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF1 trefoil factor 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBR3 transforming growth factor, beta receptor III
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TM4SF1 transmembrane 4 L six family member 1
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOP2A topoisomerase (DNA) II alpha 170kDa
TSPAN8 tetraspanin 8
USP22 ubiquitin specific peptidase 22
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon