BRD-K51918615_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

84 genes differentially expressed following the BRD-K51918615_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
C1ORF115 chromosome 1 open reading frame 115
CA2 carbonic anhydrase II
CAST calpastatin
CLIC4 chloride intracellular channel 4
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
EPS8 epidermal growth factor receptor pathway substrate 8
FADS1 fatty acid desaturase 1
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FDPS farnesyl diphosphate synthase
FUCA1 fucosidase, alpha-L- 1, tissue
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOXC6 homeobox C6
LDLR low density lipoprotein receptor
LMO2 LIM domain only 2 (rhombotin-like 1)
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MAP7 microtubule-associated protein 7
MSMO1 methylsterol monooxygenase 1
NME4 NME/NM23 nucleoside diphosphate kinase 4
OBSL1 obscurin-like 1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
POLR1D polymerase (RNA) I polypeptide D, 16kDa
QPCT glutaminyl-peptide cyclotransferase
RHOBTB3 Rho-related BTB domain containing 3
SASH1 SAM and SH3 domain containing 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCYL3 SCY1-like 3 (S. cerevisiae)
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
SORBS2 sorbin and SH3 domain containing 2
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SQLE squalene epoxidase
SRC SRC proto-oncogene, non-receptor tyrosine kinase
TOX3 TOX high mobility group box family member 3

decreased expression

Symbol Name
ACKR3 atypical chemokine receptor 3
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ASPN asporin
CD24 CD24 molecule
CDC42 cell division cycle 42
CELF2 CUGBP, Elav-like family member 2
COL6A1 collagen, type VI, alpha 1
COL6A3 collagen, type VI, alpha 3
CSRP2 cysteine and glycine-rich protein 2
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL8 chemokine (C-X-C motif) ligand 8
DHRS2 dehydrogenase/reductase (SDR family) member 2
DSP desmoplakin
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGR1 early growth response 1
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAM129A family with sequence similarity 129, member A
FBN2 fibrillin 2
G0S2 G0/G1 switch 2
GCH1 GTP cyclohydrolase 1
IER3 immediate early response 3
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IRF1 interferon regulatory factor 1
KLF10 Kruppel-like factor 10
KLF4 Kruppel-like factor 4 (gut)
LCN2 lipocalin 2
MCL1 myeloid cell leukemia 1
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial
ODC1 ornithine decarboxylase 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLBD1 phospholipase B domain containing 1
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RNF167 ring finger protein 167
SCAND1 SCAN domain containing 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
STK10 serine/threonine kinase 10
STX1A syntaxin 1A (brain)
THBS4 thrombospondin 4
WARS tryptophanyl-tRNA synthetase
ZNF423 zinc finger protein 423