BRD-K51781482_IKK-3 Inhibitor IX_VCAP_6.0_h_6.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

55 genes differentially expressed following the BRD-K51781482_IKK-3 Inhibitor IX_VCAP_6.0_h_6.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
CD36 CD36 molecule (thrombospondin receptor)
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CLIC4 chloride intracellular channel 4
COBL cordon-bleu WH2 repeat protein
CYB5A cytochrome b5 type A (microsomal)
DMXL2 Dmx-like 2
DSC2 desmocollin 2
ESRP1 epithelial splicing regulatory protein 1
GHR growth hormone receptor
GLRX glutaredoxin (thioltransferase)
GPER1 G protein-coupled estrogen receptor 1
HEBP2 heme binding protein 2
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
MAP7 microtubule-associated protein 7
MTSS1 metastasis suppressor 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
PELI1 pellino E3 ubiquitin protein ligase 1
PERP PERP, TP53 apoptosis effector
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
SEPP1 selenoprotein P, plasma, 1
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SYNJ2 synaptojanin 2
THBS1 thrombospondin 1
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM47 transmembrane protein 47
TOX3 TOX high mobility group box family member 3
ZFAND5 zinc finger, AN1-type domain 5

decreased expression

Symbol Name
AIM1 absent in melanoma 1
CAV1 caveolin 1, caveolae protein, 22kDa
CCL20 chemokine (C-C motif) ligand 20
CCL5 chemokine (C-C motif) ligand 5
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CFI complement factor I
CSRP1 cysteine and glycine-rich protein 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
FBLN1 fibulin 1
G6PD glucose-6-phosphate dehydrogenase
MDK midkine (neurite growth-promoting factor 2)
MMP7 matrix metallopeptidase 7
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
MYH11 myosin, heavy chain 11, smooth muscle
NMU neuromedin U
TGFB1I1 transforming growth factor beta 1 induced transcript 1
Funding