BRD-K51683034_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

75 genes differentially expressed following the BRD-K51683034_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ASNS asparagine synthetase (glutamine-hydrolyzing)
CD99 CD99 molecule
CES1 carboxylesterase 1
COL3A1 collagen, type III, alpha 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
FZD7 frizzled class receptor 7
GCLC glutamate-cysteine ligase, catalytic subunit
GNAS GNAS complex locus
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
KDM5D lysine (K)-specific demethylase 5D
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A
PCOLCE procollagen C-endopeptidase enhancer
PHYH phytanoyl-CoA 2-hydroxylase
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
POSTN periostin, osteoblast specific factor
PRAME preferentially expressed antigen in melanoma
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RGS2 regulator of G-protein signaling 2
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
TCF12 transcription factor 12
TLR4 toll-like receptor 4
TUSC3 tumor suppressor candidate 3
UBL3 ubiquitin-like 3
UGCG UDP-glucose ceramide glucosyltransferase

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADGRG2 adhesion G protein-coupled receptor G2
ADGRG6 adhesion G protein-coupled receptor G6
AHNAK2 AHNAK nucleoprotein 2
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
BSG basigin (Ok blood group)
C1ORF116 chromosome 1 open reading frame 116
CA2 carbonic anhydrase II
CAV1 caveolin 1, caveolae protein, 22kDa
CDC25A cell division cycle 25A
CPE carboxypeptidase E
CTNND1 catenin (cadherin-associated protein), delta 1
CXADR coxsackie virus and adenovirus receptor
CXCL14 chemokine (C-X-C motif) ligand 14
DHCR24 24-dehydrocholesterol reductase
DKK3 dickkopf WNT signaling pathway inhibitor 3
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
F11R F11 receptor
F2RL1 coagulation factor II (thrombin) receptor-like 1
FGG fibrinogen gamma chain
GBP1 guanylate binding protein 1, interferon-inducible
GJA1 gap junction protein, alpha 1, 43kDa
HIST1H2BD histone cluster 1, H2bd
ITGA6 integrin, alpha 6
LAMP3 lysosomal-associated membrane protein 3
LAPTM4B lysosomal protein transmembrane 4 beta
NPTX2 neuronal pentraxin II
PRODH proline dehydrogenase (oxidase) 1
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PXDN peroxidasin
SDC1 syndecan 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SHB Src homology 2 domain containing adaptor protein B
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
STXBP2 syntaxin binding protein 2
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae)
TFRC transferrin receptor
TGFB1 transforming growth factor, beta 1
TMEM45A transmembrane protein 45A
TMSB15A thymosin beta 15a
TUBA4A tubulin, alpha 4a
TUBB2A tubulin, beta 2A class IIa
ZNF395 zinc finger protein 395