BRD-K51608872_N,N-dimethyl-6-({[1-(1-naphthyl)-1H-tetrazol-5-yl]thio}methyl)-1,3,5-triazine-2,4-diamine_VCAP_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

47 genes differentially expressed following the BRD-K51608872_N,N-dimethyl-6-({[1-(1-naphthyl)-1H-tetrazol-5-yl]thio}methyl)-1,3,5-triazine-2,4-diamine_VCAP_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALOX5AP arachidonate 5-lipoxygenase-activating protein
AURKB aurora kinase B
C1QA complement component 1, q subcomponent, A chain
CD93 CD93 molecule
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CORO1A coronin, actin binding protein, 1A
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DCHS1 dachsous cadherin-related 1
DKK3 dickkopf WNT signaling pathway inhibitor 3
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM107A family with sequence similarity 107, member A
G0S2 G0/G1 switch 2
HYOU1 hypoxia up-regulated 1
IFI16 interferon, gamma-inducible protein 16
IFNAR1 interferon (alpha, beta and omega) receptor 1
LOC100505650 uncharacterized LOC100505650
MSLN mesothelin
MUC16 mucin 16, cell surface associated
PECAM1 platelet/endothelial cell adhesion molecule 1
PELI1 pellino E3 ubiquitin protein ligase 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RGS5 regulator of G-protein signaling 5
VWF von Willebrand factor

decreased expression

Symbol Name
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ANKRD12 ankyrin repeat domain 12
CA12 carbonic anhydrase XII
CCDC92 coiled-coil domain containing 92
CPM carboxypeptidase M
DMXL2 Dmx-like 2
DSP desmoplakin
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ETNK1 ethanolamine kinase 1
GLRX glutaredoxin (thioltransferase)
HES1 hes family bHLH transcription factor 1
HOXC6 homeobox C6
IGFBP6 insulin-like growth factor binding protein 6
KRT14 keratin 14, type I
NRN1 neuritin 1
PSD3 pleckstrin and Sec7 domain containing 3
SDC2 syndecan 2
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TOX3 TOX high mobility group box family member 3