BRD-K51608872_N,N-dimethyl-6-({[1-(1-naphthyl)-1H-tetrazol-5-yl]thio}methyl)-1,3,5-triazine-2,4-diamine_HT29_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

70 genes differentially expressed following the BRD-K51608872_N,N-dimethyl-6-({[1-(1-naphthyl)-1H-tetrazol-5-yl]thio}methyl)-1,3,5-triazine-2,4-diamine_HT29_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALOX5 arachidonate 5-lipoxygenase
ASPN asporin
C1ORF54 chromosome 1 open reading frame 54
CD93 CD93 molecule
COL3A1 collagen, type III, alpha 1
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DLK1 delta-like 1 homolog (Drosophila)
DOK5 docking protein 5
DPP4 dipeptidyl-peptidase 4
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
ESR1 estrogen receptor 1
FCGBP Fc fragment of IgG binding protein
GAS1 growth arrest-specific 1
GJA1 gap junction protein, alpha 1, 43kDa
JAM2 junctional adhesion molecule 2
LAPTM4B lysosomal protein transmembrane 4 beta
LUM lumican
LYZ lysozyme
MAMLD1 mastermind-like domain containing 1
MXRA5 matrix-remodelling associated 5
MYBPC1 myosin binding protein C, slow type
OLFM1 olfactomedin 1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEPP1 selenoprotein P, plasma, 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
TOX3 TOX high mobility group box family member 3
TXNL1 thioredoxin-like 1
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)

decreased expression

Symbol Name
ACTB actin, beta
AMD1 adenosylmethionine decarboxylase 1
AREG amphiregulin
CA12 carbonic anhydrase XII
CAPN2 calpain 2, (m/II) large subunit
CD24 CD24 molecule
CDC25A cell division cycle 25A
COTL1 coactosin-like F-actin binding protein 1
CSRP1 cysteine and glycine-rich protein 1
DNM1L dynamin 1-like
DUSP4 dual specificity phosphatase 4
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EREG epiregulin
FERMT1 fermitin family member 1
FKBP11 FK506 binding protein 11, 19 kDa
FLNB filamin B, beta
FOSL1 FOS-like antigen 1
FXYD2 FXYD domain containing ion transport regulator 2
G6PD glucose-6-phosphate dehydrogenase
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
KRT14 keratin 14, type I
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MKI67 marker of proliferation Ki-67
MMP7 matrix metallopeptidase 7
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLXNA2 plexin A2
PRKCD protein kinase C, delta
RAB29 RAB29, member RAS oncogene family
RBM34 RNA binding motif protein 34
RHOB ras homolog family member B
SFRP1 secreted frizzled-related protein 1
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SMAGP small cell adhesion glycoprotein
SOX4 SRY (sex determining region Y)-box 4
SPTBN1 spectrin, beta, non-erythrocytic 1
SRSF6 serine/arginine-rich splicing factor 6
TGFB1 transforming growth factor, beta 1
TPD52L1 tumor protein D52-like 1
UBE2S ubiquitin-conjugating enzyme E2S