BRD-K51608872_N,N-dimethyl-6-({[1-(1-naphthyl)-1H-tetrazol-5-yl]thio}methyl)-1,3,5-triazine-2,4-diamine_HA1E_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

66 genes differentially expressed following the BRD-K51608872_N,N-dimethyl-6-({[1-(1-naphthyl)-1H-tetrazol-5-yl]thio}methyl)-1,3,5-triazine-2,4-diamine_HA1E_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADD3 adducin 3 (gamma)
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ARPP19 cAMP-regulated phosphoprotein, 19kDa
CCL2 chemokine (C-C motif) ligand 2
CD200 CD200 molecule
CD93 CD93 molecule
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CLIC5 chloride intracellular channel 5
CST1 cystatin SN
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNPH1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1
DPYSL3 dihydropyrimidinase-like 3
EHF ets homologous factor
EYA2 EYA transcriptional coactivator and phosphatase 2
FCGBP Fc fragment of IgG binding protein
ICAM1 intercellular adhesion molecule 1
LY75 lymphocyte antigen 75
MMP9 matrix metallopeptidase 9
MUT methylmalonyl CoA mutase
PAWR PRKC, apoptosis, WT1, regulator
PDLIM5 PDZ and LIM domain 5
PDZD8 PDZ domain containing 8
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RBMS1 RNA binding motif, single stranded interacting protein 1
RGS5 regulator of G-protein signaling 5
SELE selectin E
SEPP1 selenoprotein P, plasma, 1
SOX17 SRY (sex determining region Y)-box 17
SULF1 sulfatase 1
TAC1 tachykinin, precursor 1
THY1 Thy-1 cell surface antigen
WT1 Wilms tumor 1

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AMIGO2 adhesion molecule with Ig-like domain 2
ARFIP2 ADP-ribosylation factor interacting protein 2
ASCL1 achaete-scute family bHLH transcription factor 1
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DPP4 dipeptidyl-peptidase 4
FABP7 fatty acid binding protein 7, brain
HILPDA hypoxia inducible lipid droplet-associated
HMOX1 heme oxygenase 1
HOXC10 homeobox C10
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ISG15 ISG15 ubiquitin-like modifier
KIAA0101 KIAA0101
KRT7 keratin 7, type II
LOX lysyl oxidase
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
NEFH neurofilament, heavy polypeptide
NEFL neurofilament, light polypeptide
NR2F2 nuclear receptor subfamily 2, group F, member 2
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PFKP phosphofructokinase, platelet
PKM pyruvate kinase, muscle
PLIN2 perilipin 2
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
RAB31 RAB31, member RAS oncogene family
RTN2 reticulon 2
S100A2 S100 calcium binding protein A2
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SEZ6L2 seizure related 6 homolog (mouse)-like 2
SLC38A1 solute carrier family 38, member 1
SPAG4 sperm associated antigen 4
TUBA4A tubulin, alpha 4a
ZNF395 zinc finger protein 395