BRD-K51575138_TPCA-1_HCC515_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

108 genes differentially expressed following the BRD-K51575138_TPCA-1_HCC515_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ACTA2 actin, alpha 2, smooth muscle, aorta
AGR2 anterior gradient 2
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
APOD apolipoprotein D
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
C1ORF116 chromosome 1 open reading frame 116
C6ORF48 chromosome 6 open reading frame 48
CFD complement factor D (adipsin)
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle)
CSNK1E casein kinase 1, epsilon
DCN decorin
DES desmin
DUSP1 dual specificity phosphatase 1
EFHD1 EF-hand domain family, member D1
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EPRS glutamyl-prolyl-tRNA synthetase
ETV5 ets variant 5
GPRC5A G protein-coupled receptor, class C, group 5, member A
IRS2 insulin receptor substrate 2
KRT23 keratin 23, type I
LAT2 linker for activation of T cells family, member 2
LMO2 LIM domain only 2 (rhombotin-like 1)
LPAR1 lysophosphatidic acid receptor 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYBPC1 myosin binding protein C, slow type
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NREP neuronal regeneration related protein
PHGDH phosphoglycerate dehydrogenase
PLXND1 plexin D1
PROM1 prominin 1
PRPF4 pre-mRNA processing factor 4
PSAT1 phosphoserine aminotransferase 1
PYCR1 pyrroline-5-carboxylate reductase 1
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RPS4Y1 ribosomal protein S4, Y-linked 1
S100P S100 calcium binding protein P
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SORBS2 sorbin and SH3 domain containing 2
STC2 stanniocalcin 2
TARP TCR gamma alternate reading frame protein
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TNNI2 troponin I type 2 (skeletal, fast)
TPM2 tropomyosin 2 (beta)
TRIM2 tripartite motif containing 2
TSC22D3 TSC22 domain family, member 3
TSPAN8 tetraspanin 8
WFDC2 WAP four-disulfide core domain 2
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ACKR3 atypical chemokine receptor 3
ALDOA aldolase A, fructose-bisphosphate
ARL4C ADP-ribosylation factor-like 4C
ATAD2 ATPase family, AAA domain containing 2
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
AURKB aurora kinase B
CALR calreticulin
CAV2 caveolin 2
CCL2 chemokine (C-C motif) ligand 2
CD24 CD24 molecule
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CP ceruloplasmin (ferroxidase)
CPA3 carboxypeptidase A3 (mast cell)
CPB1 carboxypeptidase B1 (tissue)
CRELD2 cysteine-rich with EGF-like domains 2
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL9 chemokine (C-X-C motif) ligand 9
EGFR epidermal growth factor receptor
ENO1 enolase 1, (alpha)
FANCI Fanconi anemia, complementation group I
GBP1 guanylate binding protein 1, interferon-inducible
GLI2 GLI family zinc finger 2
GOLGA8B golgin A8 family, member B
GPNMB glycoprotein (transmembrane) nmb
H2AFX H2A histone family, member X
HK1 hexokinase 1
IGF1R insulin-like growth factor 1 receptor
IGFBP3 insulin-like growth factor binding protein 3
KIF20A kinesin family member 20A
MARCKS myristoylated alanine-rich protein kinase C substrate
NAV2 neuron navigator 2
PBX3 pre-B-cell leukemia homeobox 3
PCDH7 protocadherin 7
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLAU plasminogen activator, urokinase
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PTMA prothymosin, alpha
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1
RCN2 reticulocalbin 2, EF-hand calcium binding domain
S100A9 S100 calcium binding protein A9
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SOCS1 suppressor of cytokine signaling 1
SPRR1B small proline-rich protein 1B
TCTN1 tectonic family member 1
TMEM14A transmembrane protein 14A
TMEM45A transmembrane protein 45A
TNC tenascin C
TOP2A topoisomerase (DNA) II alpha 170kDa
XIST X inactive specific transcript (non-protein coding)
ZFP36L1 ZFP36 ring finger protein-like 1
ZIC1 Zic family member 1