BRD-K51313569_palbociclib_HT29_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

190 genes differentially expressed following the BRD-K51313569_palbociclib_HT29_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADIRF adipogenesis regulatory factor
AGR2 anterior gradient 2
AMIGO2 adhesion molecule with Ig-like domain 2
ANXA3 annexin A3
ANXA4 annexin A4
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BASP1 brain abundant, membrane attached signal protein 1
BHLHE41 basic helix-loop-helix family, member e41
C21ORF33 chromosome 21 open reading frame 33
CCND1 cyclin D1
CD44 CD44 molecule (Indian blood group)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CTSE cathepsin E
CXCL10 chemokine (C-X-C motif) ligand 10
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DYNLT3 dynein, light chain, Tctex-type 3
ERBB2 erb-b2 receptor tyrosine kinase 2
FBP1 fructose-1,6-bisphosphatase 1
FOLR1 folate receptor 1 (adult)
FXYD3 FXYD domain containing ion transport regulator 3
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GATA6 GATA binding protein 6
GLRX glutaredoxin (thioltransferase)
GPX2 glutathione peroxidase 2
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IFI27 interferon, alpha-inducible protein 27
IGF1R insulin-like growth factor 1 receptor
LGALS3 lectin, galactoside-binding, soluble, 3
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LIMCH1 LIM and calponin homology domains 1
MAGED2 melanoma antigen family D2
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MECOM MDS1 and EVI1 complex locus
MME membrane metallo-endopeptidase
MVP major vault protein
NPDC1 neural proliferation, differentiation and control, 1
PDE1A phosphodiesterase 1A, calmodulin-dependent
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PRKCZ protein kinase C, zeta
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RPL31 ribosomal protein L31
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SH3YL1 SH3 and SYLF domain containing 1
SIDT2 SID1 transmembrane family, member 2
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC16A5 solute carrier family 16 (monocarboxylate transporter), member 5
SRPX sushi-repeat containing protein, X-linked
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOX3 TOX high mobility group box family member 3
TSPAN8 tetraspanin 8
TST thiosulfate sulfurtransferase (rhodanese)
XAF1 XIAP associated factor 1

decreased expression

Symbol Name
ANPEP alanyl (membrane) aminopeptidase
ASF1B anti-silencing function 1B histone chaperone
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATAD2 ATPase family, AAA domain containing 2
AURKA aurora kinase A
BARD1 BRCA1 associated RING domain 1
BIRC5 baculoviral IAP repeat containing 5
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BRCA1 breast cancer 1, early onset
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CCNA2 cyclin A2
CCNB2 cyclin B2
CCNE2 cyclin E2
CD36 CD36 molecule (thrombospondin receptor)
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC25B cell division cycle 25B
CDC6 cell division cycle 6
CDC7 cell division cycle 7
CDCA3 cell division cycle associated 3
CDCA8 cell division cycle associated 8
CDK1 cyclin-dependent kinase 1
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CDKN3 cyclin-dependent kinase inhibitor 3
CDT1 chromatin licensing and DNA replication factor 1
CENPA centromere protein A
CENPF centromere protein F, 350/400kDa
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CLU clusterin
CNN3 calponin 3, acidic
CPA3 carboxypeptidase A3 (mast cell)
DBF4 DBF4 zinc finger
DDB2 damage-specific DNA binding protein 2, 48kDa
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DSCC1 DNA replication and sister chromatid cohesion 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FAM129A family with sequence similarity 129, member A
FANCG Fanconi anemia, complementation group G
FANCI Fanconi anemia, complementation group I
FEN1 flap structure-specific endonuclease 1
FOXM1 forkhead box M1
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GTSE1 G-2 and S-phase expressed 1
H2AFV H2A histone family, member V
H2AFX H2A histone family, member X
HJURP Holliday junction recognition protein
HMGB1 high mobility group box 1
HMGB2 high mobility group box 2
HMMR hyaluronan-mediated motility receptor (RHAMM)
IGFBP5 insulin-like growth factor binding protein 5
KIAA0101 KIAA0101
KIF11 kinesin family member 11
KIF15 kinesin family member 15
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KIF4A kinesin family member 4A
LBR lamin B receptor
LMNB1 lamin B1
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MELK maternal embryonic leucine zipper kinase
MKI67 marker of proliferation Ki-67
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYLK myosin light chain kinase
NCAPG non-SMC condensin I complex, subunit G
NCAPG2 non-SMC condensin II complex, subunit G2
NDC80 NDC80 kinetochore complex component
NEIL3 nei endonuclease VIII-like 3 (E. coli)
NEK2 NIMA-related kinase 2
NUSAP1 nucleolar and spindle associated protein 1
OIP5 Opa interacting protein 5
OLFM1 olfactomedin 1
PARP2 poly (ADP-ribose) polymerase 2
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PEA15 phosphoprotein enriched in astrocytes 15
PHGDH phosphoglycerate dehydrogenase
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRC1 protein regulator of cytokinesis 1
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PSIP1 PC4 and SFRS1 interacting protein 1
PTTG1 pituitary tumor-transforming 1
RACGAP1 Rac GTPase activating protein 1
RAD51AP1 RAD51 associated protein 1
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RNASEH2A ribonuclease H2, subunit A
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC2A4RG SLC2A4 regulator
SMC4 structural maintenance of chromosomes 4
SPC25 SPC25, NDC80 kinetochore complex component
STMN1 stathmin 1
TACC3 transforming, acidic coiled-coil containing protein 3
TFPI2 tissue factor pathway inhibitor 2
THAP11 THAP domain containing 11
TK1 thymidine kinase 1, soluble
TMPO thymopoietin
TNC tenascin C
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TRMT5 tRNA methyltransferase 5
TTK TTK protein kinase
TUBB tubulin, beta class I
TUBB3 tubulin, beta 3 class III
TUBB4B tubulin, beta 4B class IVb
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZWINT ZW10 interacting kinetochore protein