BRD-K51313569_palbociclib_BT20_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

229 genes differentially expressed following the BRD-K51313569_palbociclib_BT20_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACLY ATP citrate lyase
ADIRF adipogenesis regulatory factor
AGR2 anterior gradient 2
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
AMIGO2 adhesion molecule with Ig-like domain 2
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
CFB complement factor B
CIB1 calcium and integrin binding 1 (calmyrin)
CLU clusterin
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
ERBB2 erb-b2 receptor tyrosine kinase 2
FABP4 fatty acid binding protein 4, adipocyte
FOLR1 folate receptor 1 (adult)
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
GATA6 GATA binding protein 6
GCLC glutamate-cysteine ligase, catalytic subunit
GPX2 glutathione peroxidase 2
GSTK1 glutathione S-transferase kappa 1
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
IDS iduronate 2-sulfatase
IDUA iduronidase, alpha-L-
IFI27 interferon, alpha-inducible protein 27
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
KRT18 keratin 18, type I
KRT19 keratin 19, type I
LCN2 lipocalin 2
LDOC1 leucine zipper, down-regulated in cancer 1
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LXN latexin
MSRB2 methionine sulfoxide reductase B2
MVP major vault protein
NEBL nebulette
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
OBSL1 obscurin-like 1
PDZK1IP1 PDZK1 interacting protein 1
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PON2 paraoxonase 2
PPOX protoporphyrinogen oxidase
PRKCD protein kinase C, delta
PTPRF protein tyrosine phosphatase, receptor type, F
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RFX5 regulatory factor X, 5 (influences HLA class II expression)
S100P S100 calcium binding protein P
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SELENBP1 selenium binding protein 1
SH3BP5 SH3-domain binding protein 5 (BTK-associated)
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
TPD52L1 tumor protein D52-like 1
TSC22D3 TSC22 domain family, member 3
TSPAN13 tetraspanin 13
UBA7 ubiquitin-like modifier activating enzyme 7
UGDH UDP-glucose 6-dehydrogenase
VAV3 vav 3 guanine nucleotide exchange factor
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
ACAT2 acetyl-CoA acetyltransferase 2
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ASF1B anti-silencing function 1B histone chaperone
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ASPN asporin
ATAD2 ATPase family, AAA domain containing 2
AURKA aurora kinase A
AURKB aurora kinase B
BIRC5 baculoviral IAP repeat containing 5
BRCA1 breast cancer 1, early onset
BTG3 BTG family, member 3
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CA2 carbonic anhydrase II
CAV1 caveolin 1, caveolae protein, 22kDa
CCNA2 cyclin A2
CCNB2 cyclin B2
CCNE2 cyclin E2
CCNF cyclin F
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC25B cell division cycle 25B
CDC25C cell division cycle 25C
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDCA3 cell division cycle associated 3
CDCA4 cell division cycle associated 4
CDCA8 cell division cycle associated 8
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CENPE centromere protein E, 312kDa
CENPF centromere protein F, 350/400kDa
CENPM centromere protein M
CENPN centromere protein N
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CHEK1 checkpoint kinase 1
CIT citron rho-interacting serine/threonine kinase
CLIC4 chloride intracellular channel 4
DBF4 DBF4 zinc finger
DEK DEK proto-oncogene
DEPDC1 DEP domain containing 1
DHFR dihydrofolate reductase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNMT1 DNA (cytosine-5-)-methyltransferase 1
DPYSL2 dihydropyrimidinase-like 2
DSCC1 DNA replication and sister chromatid cohesion 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
E2F8 E2F transcription factor 8
ECT2 epithelial cell transforming 2
EMP1 epithelial membrane protein 1
EMP3 epithelial membrane protein 3
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
EXO1 exonuclease 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FAM64A family with sequence similarity 64, member A
FANCI Fanconi anemia, complementation group I
FBXO5 F-box protein 5
FEN1 flap structure-specific endonuclease 1
FOXM1 forkhead box M1
GADD45A growth arrest and DNA-damage-inducible, alpha
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GMNN geminin, DNA replication inhibitor
GPRC5A G protein-coupled receptor, class C, group 5, member A
GTSE1 G-2 and S-phase expressed 1
H2AFX H2A histone family, member X
H2AFZ H2A histone family, member Z
HELLS helicase, lymphoid-specific
HJURP Holliday junction recognition protein
HMGB1 high mobility group box 1
HMGB2 high mobility group box 2
HMMR hyaluronan-mediated motility receptor (RHAMM)
IL17RB interleukin 17 receptor B
KIAA0101 KIAA0101
KIF11 kinesin family member 11
KIF14 kinesin family member 14
KIF15 kinesin family member 15
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KIF23 kinesin family member 23
KIF4A kinesin family member 4A
KIFC1 kinesin family member C1
LBR lamin B receptor
LMNB1 lamin B1
LMNB2 lamin B2
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MKI67 marker of proliferation Ki-67
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYBPC1 myosin binding protein C, slow type
NCAPD2 non-SMC condensin I complex, subunit D2
NCAPG non-SMC condensin I complex, subunit G
NCAPG2 non-SMC condensin II complex, subunit G2
NCAPH non-SMC condensin I complex, subunit H
NDC80 NDC80 kinetochore complex component
NEIL3 nei endonuclease VIII-like 3 (E. coli)
NEK2 NIMA-related kinase 2
NUSAP1 nucleolar and spindle associated protein 1
OIP5 Opa interacting protein 5
OSR2 odd-skipped related transciption factor 2
PARP2 poly (ADP-ribose) polymerase 2
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PLK1 polo-like kinase 1
PLP2 proteolipid protein 2 (colonic epithelium-enriched)
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRC1 protein regulator of cytokinesis 1
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PSIP1 PC4 and SFRS1 interacting protein 1
PSRC1 proline/serine-rich coiled-coil 1
PTTG1 pituitary tumor-transforming 1
RACGAP1 Rac GTPase activating protein 1
RAD51 RAD51 recombinase
RAD51AP1 RAD51 associated protein 1
RAI14 retinoic acid induced 14
RBBP8 retinoblastoma binding protein 8
RFC3 replication factor C (activator 1) 3, 38kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RNASEH2A ribonuclease H2, subunit A
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
SAP30 Sin3A-associated protein, 30kDa
SFN stratifin
SHCBP1 SHC SH2-domain binding protein 1
SMC2 structural maintenance of chromosomes 2
SMC4 structural maintenance of chromosomes 4
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
SPAG5 sperm associated antigen 5
SPC25 SPC25, NDC80 kinetochore complex component
SPDL1 spindle apparatus coiled-coil protein 1
STMN1 stathmin 1
TACC3 transforming, acidic coiled-coil containing protein 3
TEAD4 TEA domain family member 4
TK1 thymidine kinase 1, soluble
TMPO thymopoietin
TMSB15A thymosin beta 15a
TNC tenascin C
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TRIP13 thyroid hormone receptor interactor 13
TRMT5 tRNA methyltransferase 5
TROAP trophinin associated protein
TSPAN4 tetraspanin 4
TTK TTK protein kinase
TUBB2A tubulin, beta 2A class IIa
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
WEE1 WEE1 G2 checkpoint kinase
WHSC1 Wolf-Hirschhorn syndrome candidate 1
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZWINT ZW10 interacting kinetochore protein