BRD-K51276371_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

75 genes differentially expressed following the BRD-K51276371_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
BACE2 beta-site APP-cleaving enzyme 2
CCL20 chemokine (C-C motif) ligand 20
CFB complement factor B
COL10A1 collagen, type X, alpha 1
COL11A1 collagen, type XI, alpha 1
EREG epiregulin
FSD1 fibronectin type III and SPRY domain containing 1
GEM GTP binding protein overexpressed in skeletal muscle
GJA1 gap junction protein, alpha 1, 43kDa
GNLY granulysin
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
IDO1 indoleamine 2,3-dioxygenase 1
IGFBP7 insulin-like growth factor binding protein 7
IL7R interleukin 7 receptor
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
KCTD14 potassium channel tetramerization domain containing 14
KRT18 keratin 18, type I
LAPTM4B lysosomal protein transmembrane 4 beta
NNMT nicotinamide N-methyltransferase
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLA2G16 phospholipase A2, group XVI
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PLS1 plastin 1
PRKCQ protein kinase C, theta
PSTPIP2 proline-serine-threonine phosphatase interacting protein 2
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RNF167 ring finger protein 167
RPIA ribose 5-phosphate isomerase A
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
STX1A syntaxin 1A (brain)
SULF1 sulfatase 1
TIMP1 TIMP metallopeptidase inhibitor 1
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TXNDC9 thioredoxin domain containing 9
VCAN versican
VGLL4 vestigial-like family member 4
VIM vimentin

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
C6ORF62 chromosome 6 open reading frame 62
CA2 carbonic anhydrase II
CDC42 cell division cycle 42
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CTSZ cathepsin Z
DMD dystrophin
DUSP22 dual specificity phosphatase 22
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FCGBP Fc fragment of IgG binding protein
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FGFR3 fibroblast growth factor receptor 3
HSPA1A heat shock 70kDa protein 1A
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IGFBP4 insulin-like growth factor binding protein 4
IL6R interleukin 6 receptor
ING2 inhibitor of growth family, member 2
KLK11 kallikrein-related peptidase 11
LPL lipoprotein lipase
LY6D lymphocyte antigen 6 complex, locus D
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
PARP2 poly (ADP-ribose) polymerase 2
PIR pirin (iron-binding nuclear protein)
PPAP2B phosphatidic acid phosphatase type 2B
RHOBTB3 Rho-related BTB domain containing 3
RPS11 ribosomal protein S11
RXRA retinoid X receptor, alpha
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TMEM100 transmembrane protein 100
TPM1 tropomyosin 1 (alpha)
TRIM29 tripartite motif containing 29