BRD-K50387473_XMD-892_PC3_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

109 genes differentially expressed following the BRD-K50387473_XMD-892_PC3_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AHNAK2 AHNAK nucleoprotein 2
AMOTL2 angiomotin like 2
ARHGEF18 Rho/Rac guanine nucleotide exchange factor (GEF) 18
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHGB chromogranin B
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
ETV5 ets variant 5
FGF2 fibroblast growth factor 2 (basic)
GULP1 GULP, engulfment adaptor PTB domain containing 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HOMER1 homer scaffolding protein 1
KLF10 Kruppel-like factor 10
LAPTM4B lysosomal protein transmembrane 4 beta
MMP1 matrix metallopeptidase 1
NCAM1 neural cell adhesion molecule 1
PCDH9 protocadherin 9
PEBP1 phosphatidylethanolamine binding protein 1
PLAT plasminogen activator, tissue
PRKACB protein kinase, cAMP-dependent, catalytic, beta
RBP1 retinol binding protein 1, cellular
RGS2 regulator of G-protein signaling 2
SECISBP2L SECIS binding protein 2-like
STAT1 signal transducer and activator of transcription 1, 91kDa
STXBP1 syntaxin binding protein 1
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TSC22D2 TSC22 domain family, member 2
TUBB2B tubulin, beta 2B class IIb
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae)

decreased expression

Symbol Name
ACSL5 acyl-CoA synthetase long-chain family member 5
AIM1 absent in melanoma 1
AKR1C3 aldo-keto reductase family 1, member C3
ALOX15B arachidonate 15-lipoxygenase, type B
ANO1 anoctamin 1, calcium activated chloride channel
AZGP1 alpha-2-glycoprotein 1, zinc-binding
CA12 carbonic anhydrase XII
CASP7 caspase 7, apoptosis-related cysteine peptidase
CD44 CD44 molecule (Indian blood group)
CD52 CD52 molecule
CD58 CD58 molecule
CD59 CD59 molecule, complement regulatory protein
CD8A CD8a molecule
CFI complement factor I
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
CP ceruloplasmin (ferroxidase)
CSTA cystatin A (stefin A)
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DTX4 deltex 4, E3 ubiquitin ligase
EHF ets homologous factor
ENO1 enolase 1, (alpha)
GLIPR1 GLI pathogenesis-related 1
GNLY granulysin
GSTT1 glutathione S-transferase theta 1
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HOPX HOP homeobox
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IGF1 insulin-like growth factor 1 (somatomedin C)
IGFBP3 insulin-like growth factor binding protein 3
IGKC immunoglobulin kappa constant
IGL immunoglobulin lambda locus
IL1B interleukin 1, beta
IL1R1 interleukin 1 receptor, type I
JCHAIN joining chain of multimeric IgA and IgM
KRT15 keratin 15, type I
KRT17 keratin 17, type I
KRT23 keratin 23, type I
KRT5 keratin 5, type II
KRT8 keratin 8, type II
LTF lactotransferrin
LY75 lymphocyte antigen 75
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3
MDK midkine (neurite growth-promoting factor 2)
MMP9 matrix metallopeptidase 9
MNDA myeloid cell nuclear differentiation antigen
N4BP2L1 NEDD4 binding protein 2-like 1
NDRG2 NDRG family member 2
NRIP1 nuclear receptor interacting protein 1
PEA15 phosphoprotein enriched in astrocytes 15
PRKCH protein kinase C, eta
RAB25 RAB25, member RAS oncogene family
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RNASE4 ribonuclease, RNase A family, 4
RTP4 receptor (chemosensory) transporter protein 4
S100A2 S100 calcium binding protein A2
S100A4 S100 calcium binding protein A4
SCGB2A1 secretoglobin, family 2A, member 1
SEPP1 selenoprotein P, plasma, 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SNAI2 snail family zinc finger 2
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
STEAP1 six transmembrane epithelial antigen of the prostate 1
TM9SF3 transmembrane 9 superfamily member 3
TRIB3 tribbles pseudokinase 3
VCAN versican
VEGFA vascular endothelial growth factor A
VTCN1 V-set domain containing T cell activation inhibitor 1
WFDC2 WAP four-disulfide core domain 2
WNT5A wingless-type MMTV integration site family, member 5A