BRD-K50234570_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

98 genes differentially expressed following the BRD-K50234570_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
BAG3 BCL2-associated athanogene 3
BTG2 BTG family, member 2
CAB39 calcium binding protein 39
CBS cystathionine-beta-synthase
CENPE centromere protein E, 312kDa
CLTC clathrin, heavy chain (Hc)
CNOT4 CCR4-NOT transcription complex, subunit 4
COL11A1 collagen, type XI, alpha 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
FAM129A family with sequence similarity 129, member A
FBXO11 F-box protein 11
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
HSPA13 heat shock protein 70kDa family, member 13
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
JUN jun proto-oncogene
LAMP1 lysosomal-associated membrane protein 1
LBH limb bud and heart development
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
NGRN neugrin, neurite outgrowth associated
PXMP2 peroxisomal membrane protein 2, 22kDa
SELENBP1 selenium binding protein 1
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SHROOM2 shroom family member 2
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
TXNIP thioredoxin interacting protein

decreased expression

Symbol Name
ACTN1 actinin, alpha 1
ADD3 adducin 3 (gamma)
ADGRL2 adhesion G protein-coupled receptor L2
AKAP12 A kinase (PRKA) anchor protein 12
AKT3 v-akt murine thymoma viral oncogene homolog 3
AMD1 adenosylmethionine decarboxylase 1
AMIGO2 adhesion molecule with Ig-like domain 2
APOA1 apolipoprotein A-I
ARHGAP29 Rho GTPase activating protein 29
C7 complement component 7
CCL19 chemokine (C-C motif) ligand 19
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CHGB chromogranin B
CP ceruloplasmin (ferroxidase)
CTGF connective tissue growth factor
DCN decorin
DEPTOR DEP domain containing MTOR-interacting protein
DHRS2 dehydrogenase/reductase (SDR family) member 2
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLK1 delta-like 1 homolog (Drosophila)
DPYSL2 dihydropyrimidinase-like 2
DPYSL3 dihydropyrimidinase-like 3
DST dystonin
DUSP6 dual specificity phosphatase 6
EFHD2 EF-hand domain family, member D2
ENC1 ectodermal-neural cortex 1 (with BTB domain)
FERMT2 fermitin family member 2
FGB fibrinogen beta chain
FGG fibrinogen gamma chain
GJA1 gap junction protein, alpha 1, 43kDa
HDAC9 histone deacetylase 9
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IL13RA2 interleukin 13 receptor, alpha 2
KRT14 keratin 14, type I
KRT19 keratin 19, type I
KRT7 keratin 7, type II
LAMC1 laminin, gamma 1 (formerly LAMB2)
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAP7 microtubule-associated protein 7
MARCKS myristoylated alanine-rich protein kinase C substrate
MMP7 matrix metallopeptidase 7
MMP9 matrix metallopeptidase 9
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
ORM1 orosomucoid 1
PERP PERP, TP53 apoptosis effector
QPCT glutaminyl-peptide cyclotransferase
RBP4 retinol binding protein 4, plasma
RFTN1 raftlin, lipid raft linker 1
RGS4 regulator of G-protein signaling 4
RGS5 regulator of G-protein signaling 5
S100A9 S100 calcium binding protein A9
SCG2 secretogranin II
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SMNDC1 survival motor neuron domain containing 1
SOX9 SRY (sex determining region Y)-box 9
SRC SRC proto-oncogene, non-receptor tyrosine kinase
TACSTD2 tumor-associated calcium signal transducer 2
TM4SF1 transmembrane 4 L six family member 1
TOX3 TOX high mobility group box family member 3
TPD52 tumor protein D52
VNN1 vanin 1