BRD-K50168500_canertinib_SKBR3_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

178 genes differentially expressed following the BRD-K50168500_canertinib_SKBR3_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ACP5 acid phosphatase 5, tartrate resistant
ADIRF adipogenesis regulatory factor
AGR2 anterior gradient 2
ANKRD10 ankyrin repeat domain 10
ANKRD36B ankyrin repeat domain 36B
APOD apolipoprotein D
ASCL1 achaete-scute family bHLH transcription factor 1
BPIFA1 BPI fold containing family A, member 1
BTG1 B-cell translocation gene 1, anti-proliferative
C14ORF132 chromosome 14 open reading frame 132
CAT catalase
CBR3 carbonyl reductase 3
CD53 CD53 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CELF2 CUGBP, Elav-like family member 2
CEMIP cell migration inducing protein, hyaluronan binding
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLDN10 claudin 10
CYTIP cytohesin 1 interacting protein
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DDB2 damage-specific DNA binding protein 2, 48kDa
DEPTOR DEP domain containing MTOR-interacting protein
DLK1 delta-like 1 homolog (Drosophila)
EIF4B eukaryotic translation initiation factor 4B
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative)
ERBB3 erb-b2 receptor tyrosine kinase 3
EXPH5 exophilin 5
FAM102A family with sequence similarity 102, member A
FAM129A family with sequence similarity 129, member A
FBP1 fructose-1,6-bisphosphatase 1
FOLR1 folate receptor 1 (adult)
FXR1 fragile X mental retardation, autosomal homolog 1
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GRN granulin
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit
HIST1H2BD histone cluster 1, H2bd
HMOX1 heme oxygenase 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
IGKV4-1 immunoglobulin kappa variable 4-1
KAT6B K(lysine) acetyltransferase 6B
KIAA1324 KIAA1324
KLHL24 kelch-like family member 24
KRT18 keratin 18, type I
KRT19 keratin 19, type I
LAMP2 lysosomal-associated membrane protein 2
LAPTM4B lysosomal protein transmembrane 4 beta
LXN latexin
MAN1A1 mannosidase, alpha, class 1A, member 1
MCOLN1 mucolipin 1
MGLL monoglyceride lipase
MLPH melanophilin
MVP major vault protein
N4BP2L2 NEDD4 binding protein 2-like 2
NBPF10 neuroblastoma breakpoint family, member 10
NUCB2 nucleobindin 2
OBSL1 obscurin-like 1
OLFML3 olfactomedin-like 3
ORAI3 ORAI calcium release-activated calcium modulator 3
PCCA propionyl CoA carboxylase, alpha polypeptide
PCMTD2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2
PLIN2 perilipin 2
PRSS8 protease, serine, 8
QPRT quinolinate phosphoribosyltransferase
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RNASET2 ribonuclease T2
RTN2 reticulon 2
SAT1 spermidine/spermine N1-acetyltransferase 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SDCBP syndecan binding protein (syntenin)
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SEPP1 selenoprotein P, plasma, 1
SOCS2 suppressor of cytokine signaling 2
SPDEF SAM pointed domain containing ETS transcription factor
SRGN serglycin
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SYT1 synaptotagmin I
TFF3 trefoil factor 3 (intestinal)
TOM1L1 target of myb1 (chicken)-like 1
TPBG trophoblast glycoprotein
TPP1 tripeptidyl peptidase I
TPST2 tyrosylprotein sulfotransferase 2
TRIM2 tripartite motif containing 2
TRPM4 transient receptor potential cation channel, subfamily M, member 4
TXNIP thioredoxin interacting protein
UBXN4 UBX domain protein 4
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
WFDC2 WAP four-disulfide core domain 2
WIPI1 WD repeat domain, phosphoinositide interacting 1
XBP1 X-box binding protein 1
ZNF652 zinc finger protein 652

decreased expression

Symbol Name
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AURKA aurora kinase A
BIRC5 baculoviral IAP repeat containing 5
BMP2 bone morphogenetic protein 2
CCL2 chemokine (C-C motif) ligand 2
CCNA2 cyclin A2
CCND1 cyclin D1
CCNF cyclin F
CD24 CD24 molecule
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
CDC6 cell division cycle 6
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CEP55 centrosomal protein 55kDa
CKS2 CDC28 protein kinase regulatory subunit 2
COL4A6 collagen, type IV, alpha 6
CORO1A coronin, actin binding protein, 1A
CXCL8 chemokine (C-X-C motif) ligand 8
DCK deoxycytidine kinase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EMP1 epithelial membrane protein 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FABP7 fatty acid binding protein 7, brain
GAL galanin/GMAP prepropeptide
GBP1 guanylate binding protein 1, interferon-inducible
GINS2 GINS complex subunit 2 (Psf2 homolog)
GPX3 glutathione peroxidase 3
HIGD1A HIG1 hypoxia inducible domain family, member 1A
HOPX HOP homeobox
IFRD2 interferon-related developmental regulator 2
IGL immunoglobulin lambda locus
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KRT13 keratin 13, type I
KRT14 keratin 14, type I
KRT16 keratin 16, type I
KRT17 keratin 17, type I
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
KRT7 keratin 7, type II
KRT81 keratin 81, type II
LUM lumican
MAL mal, T-cell differentiation protein
MCM10 minichromosome maintenance complex component 10
MELK maternal embryonic leucine zipper kinase
MRTO4 mRNA turnover 4 homolog (S. cerevisiae)
MT1X metallothionein 1X
MT2A metallothionein 2A
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NOP16 NOP16 nucleolar protein
ODC1 ornithine decarboxylase 1
PBK PDZ binding kinase
PI3 peptidase inhibitor 3, skin-derived
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POSTN periostin, osteoblast specific factor
PRKCD protein kinase C, delta
PTGDS prostaglandin D2 synthase 21kDa (brain)
RFC5 replication factor C (activator 1) 5, 36.5kDa
RRM2 ribonucleotide reductase M2
S100A2 S100 calcium binding protein A2
S100A7 S100 calcium binding protein A7
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SHCBP1 SHC SH2-domain binding protein 1
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13
SMC4 structural maintenance of chromosomes 4
SPINK1 serine peptidase inhibitor, Kazal type 1
SPRR1A small proline-rich protein 1A
SPRR1B small proline-rich protein 1B
SRM spermidine synthase
SRSF6 serine/arginine-rich splicing factor 6
TOP2A topoisomerase (DNA) II alpha 170kDa
TPM1 tropomyosin 1 (alpha)
TRIP13 thyroid hormone receptor interactor 13
TUBA4A tubulin, alpha 4a
TUBB2A tubulin, beta 2A class IIa
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S