BRD-K50168500_canertinib_HCC515_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

164 genes differentially expressed following the BRD-K50168500_canertinib_HCC515_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ANPEP alanyl (membrane) aminopeptidase
ANXA4 annexin A4
APOC1 apolipoprotein C-I
ARID5B AT rich interactive domain 5B (MRF1-like)
BID BH3 interacting domain death agonist
C10ORF10 chromosome 10 open reading frame 10
C1ORF115 chromosome 1 open reading frame 115
C3 complement component 3
CAPN1 calpain 1, (mu/I) large subunit
CAST calpastatin
CAT catalase
CD93 CD93 molecule
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CFB complement factor B
CFD complement factor D (adipsin)
CHMP6 charged multivesicular body protein 6
CP ceruloplasmin (ferroxidase)
CYB5A cytochrome b5 type A (microsomal)
CYFIP1 cytoplasmic FMR1 interacting protein 1
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DEFB1 defensin, beta 1
DHCR24 24-dehydrocholesterol reductase
DIO1 deiodinase, iodothyronine, type I
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EIF4B eukaryotic translation initiation factor 4B
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FGA fibrinogen alpha chain
FGB fibrinogen beta chain
FGFR2 fibroblast growth factor receptor 2
FGG fibrinogen gamma chain
FMO3 flavin containing monooxygenase 3
FOXO3 forkhead box O3
FXR1 fragile X mental retardation, autosomal homolog 1
GLUL glutamate-ammonia ligase
GSTA1 glutathione S-transferase alpha 1
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
IL6R interleukin 6 receptor
INHBB inhibin, beta B
INSR insulin receptor
IRF9 interferon regulatory factor 9
KLHL24 kelch-like family member 24
KRT5 keratin 5, type II
LIMK2 LIM domain kinase 2
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MME membrane metallo-endopeptidase
MSMB microseminoprotein, beta-
MUC1 mucin 1, cell surface associated
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NCF4 neutrophil cytosolic factor 4, 40kDa
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NUPR1 nuclear protein, transcriptional regulator, 1
PIR pirin (iron-binding nuclear protein)
PLEK pleckstrin
PLVAP plasmalemma vesicle associated protein
PYCARD PYD and CARD domain containing
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RGS1 regulator of G-protein signaling 1
RPL31 ribosomal protein L31
RPS4Y1 ribosomal protein S4, Y-linked 1
RRAGD Ras-related GTP binding D
SCGB2A2 secretoglobin, family 2A, member 2
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
SPON2 spondin 2, extracellular matrix protein
SPP1 secreted phosphoprotein 1
SQLE squalene epoxidase
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SYBU syntabulin (syntaxin-interacting)
TM7SF2 transmembrane 7 superfamily member 2
TOM1L1 target of myb1 (chicken)-like 1
TPP1 tripeptidyl peptidase I
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VAT1 vesicle amine transport 1
VTCN1 V-set domain containing T cell activation inhibitor 1
WIPI1 WD repeat domain, phosphoinositide interacting 1
XBP1 X-box binding protein 1
ZNF91 zinc finger protein 91
ZSCAN31 zinc finger and SCAN domain containing 31

decreased expression

Symbol Name
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AMD1 adenosylmethionine decarboxylase 1
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
AREG amphiregulin
ARL4C ADP-ribosylation factor-like 4C
AURKB aurora kinase B
AXL AXL receptor tyrosine kinase
CCND1 cyclin D1
CDA cytidine deaminase
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
CKB creatine kinase, brain
COL1A1 collagen, type I, alpha 1
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
CYCS cytochrome c, somatic
CYTH1 cytohesin 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DPYSL2 dihydropyrimidinase-like 2
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EFHD2 EF-hand domain family, member D2
EGFR epidermal growth factor receptor
EGR3 early growth response 3
EPHB2 EPH receptor B2
EREG epiregulin
ETV1 ets variant 1
F3 coagulation factor III (thromboplastin, tissue factor)
FLRT2 fibronectin leucine rich transmembrane protein 2
FN1 fibronectin 1
FOSL1 FOS-like antigen 1
G0S2 G0/G1 switch 2
GAL galanin/GMAP prepropeptide
GLIPR1 GLI pathogenesis-related 1
GPRC5A G protein-coupled receptor, class C, group 5, member A
HEPH hephaestin
IER3 immediate early response 3
IL13RA2 interleukin 13 receptor, alpha 2
JUN jun proto-oncogene
KIF14 kinesin family member 14
LIF leukemia inhibitory factor
LPAR1 lysophosphatidic acid receptor 1
LUM lumican
MALL mal, T-cell differentiation protein-like
MCM10 minichromosome maintenance complex component 10
MEX3D mex-3 RNA binding family member D
MGLL monoglyceride lipase
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PFKP phosphofructokinase, platelet
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLAT plasminogen activator, tissue
PMEPA1 prostate transmembrane protein, androgen induced 1
PNMA2 paraneoplastic Ma antigen 2
POSTN periostin, osteoblast specific factor
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRSS3 protease, serine, 3
PTRF polymerase I and transcript release factor
RGS4 regulator of G-protein signaling 4
RRM2 ribonucleotide reductase M2
SATB2 SATB homeobox 2
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFRP1 secreted frizzled-related protein 1
SPRY2 sprouty homolog 2 (Drosophila)
SPRY4 sprouty homolog 4 (Drosophila)
TGM2 transglutaminase 2
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNC tenascin C
TSPAN8 tetraspanin 8
TUBB6 tubulin, beta 6 class V
USP6NL USP6 N-terminal like
XIST X inactive specific transcript (non-protein coding)