BRD-K50168500_canertinib_HA1E_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

113 genes differentially expressed following the BRD-K50168500_canertinib_HA1E_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ADGRG6 adhesion G protein-coupled receptor G6
AEBP1 AE binding protein 1
APOL1 apolipoprotein L, 1
BST2 bone marrow stromal cell antigen 2
C8ORF4 chromosome 8 open reading frame 4
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CLGN calmegin
COL10A1 collagen, type X, alpha 1
CPT1A carnitine palmitoyltransferase 1A (liver)
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FAIM Fas apoptotic inhibitory molecule
GCH1 GTP cyclohydrolase 1
H2AFX H2A histone family, member X
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IFI27 interferon, alpha-inducible protein 27
IFI30 interferon, gamma-inducible protein 30
IFI35 interferon-induced protein 35
IFI6 interferon, alpha-inducible protein 6
IFIT3 interferon-induced protein with tetratricopeptide repeats 3
IRS2 insulin receptor substrate 2
KRT18 keratin 18, type I
KRT8 keratin 8, type II
LACTB2 lactamase, beta 2
MEGF9 multiple EGF-like-domains 9
N4BP2L1 NEDD4 binding protein 2-like 1
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa
PIR pirin (iron-binding nuclear protein)
PLBD1 phospholipase B domain containing 1
PLSCR1 phospholipid scramblase 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPON1 spondin 1, extracellular matrix protein
SQSTM1 sequestosome 1
STAT1 signal transducer and activator of transcription 1, 91kDa
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
UBE2L6 ubiquitin-conjugating enzyme E2L 6

decreased expression

Symbol Name
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CAV1 caveolin 1, caveolae protein, 22kDa
CCNB2 cyclin B2
CD44 CD44 molecule (Indian blood group)
CFLAR CASP8 and FADD-like apoptosis regulator
COL1A2 collagen, type I, alpha 2
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL13 chemokine (C-X-C motif) ligand 13
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
DKK1 dickkopf WNT signaling pathway inhibitor 1
DPT dermatopontin
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGR1 early growth response 1
EPB41L3 erythrocyte membrane protein band 4.1-like 3
EPHA3 EPH receptor A3
FABP7 fatty acid binding protein 7, brain
FAM129A family with sequence similarity 129, member A
FGFBP1 fibroblast growth factor binding protein 1
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2
GLIPR1 GLI pathogenesis-related 1
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IDI1 isopentenyl-diphosphate delta isomerase 1
IGF1R insulin-like growth factor 1 receptor
IGFBP3 insulin-like growth factor binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
IGL immunoglobulin lambda locus
INSIG1 insulin induced gene 1
JAG1 jagged 1
KRT14 keratin 14, type I
KRT5 keratin 5, type II
LGALS3 lectin, galactoside-binding, soluble, 3
LRRC17 leucine rich repeat containing 17
LRRN3 leucine rich repeat neuronal 3
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
LTF lactotransferrin
LUM lumican
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MALL mal, T-cell differentiation protein-like
MGP matrix Gla protein
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MSMO1 methylsterol monooxygenase 1
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1X metallothionein 1X
NRN1 neuritin 1
OAT ornithine aminotransferase
PEG10 paternally expressed 10
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PTN pleiotrophin
S100A7 S100 calcium binding protein A7
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SFRP1 secreted frizzled-related protein 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SOX9 SRY (sex determining region Y)-box 9
SQLE squalene epoxidase
TCF4 transcription factor 4
TGFBI transforming growth factor, beta-induced, 68kDa
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TNC tenascin C
TNFRSF17 tumor necrosis factor receptor superfamily, member 17
TNS1 tensin 1
TPM2 tropomyosin 2 (beta)
VEGFC vascular endothelial growth factor C
VTCN1 V-set domain containing T cell activation inhibitor 1
ZBTB18 zinc finger and BTB domain containing 18