BRD-K50168500_canertinib_A375_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

99 genes differentially expressed following the BRD-K50168500_canertinib_A375_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR1C1 aldo-keto reductase family 1, member C1
ALAS1 5'-aminolevulinate synthase 1
ANO10 anoctamin 10
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
C8ORF4 chromosome 8 open reading frame 4
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COMT catechol-O-methyltransferase
CTTN cortactin
DDIT3 DNA-damage-inducible transcript 3
EGR1 early growth response 1
GDF15 growth differentiation factor 15
GPNMB glycoprotein (transmembrane) nmb
GPR137B G protein-coupled receptor 137B
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
ISG20 interferon stimulated exonuclease gene 20kDa
KIAA0226L KIAA0226-like
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MME membrane metallo-endopeptidase
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NRCAM neuronal cell adhesion molecule
NUPR1 nuclear protein, transcriptional regulator, 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PHYH phytanoyl-CoA 2-hydroxylase
PIR pirin (iron-binding nuclear protein)
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
REG1A regenerating islet-derived 1 alpha
RGS1 regulator of G-protein signaling 1
RRAGD Ras-related GTP binding D
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPP1 secreted phosphoprotein 1
SQSTM1 sequestosome 1
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TPP1 tripeptidyl peptidase I
TRIB3 tribbles pseudokinase 3
VEGFA vascular endothelial growth factor A

decreased expression

Symbol Name
AURKA aurora kinase A
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CCNA2 cyclin A2
CD24 CD24 molecule
CD59 CD59 molecule, complement regulatory protein
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
COL3A1 collagen, type III, alpha 1
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DPYSL2 dihydropyrimidinase-like 2
DPYSL3 dihydropyrimidinase-like 3
EGFR epidermal growth factor receptor
ERBB3 erb-b2 receptor tyrosine kinase 3
ESR1 estrogen receptor 1
GPER1 G protein-coupled estrogen receptor 1
HOPX HOP homeobox
IFITM3 interferon induced transmembrane protein 3
IGFBP7 insulin-like growth factor binding protein 7
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
LUM lumican
LYZ lysozyme
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
NUSAP1 nucleolar and spindle associated protein 1
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PLAT plasminogen activator, tissue
PNMA2 paraneoplastic Ma antigen 2
PODXL podocalyxin-like
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
RBM47 RNA binding motif protein 47
SEPT9 septin 9
SFRP1 secreted frizzled-related protein 1
SMC4 structural maintenance of chromosomes 4
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
STMN1 stathmin 1
TACSTD2 tumor-associated calcium signal transducer 2
TGFB1 transforming growth factor, beta 1
TJP2 tight junction protein 2
TM4SF1 transmembrane 4 L six family member 1
TMSB15A thymosin beta 15a
TNS3 tensin 3
TOP2A topoisomerase (DNA) II alpha 170kDa
TPM1 tropomyosin 1 (alpha)
TSPAN13 tetraspanin 13
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1