BRD-K50140147_NVP-TAE684_SKBR3_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

91 genes differentially expressed following the BRD-K50140147_NVP-TAE684_SKBR3_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADA adenosine deaminase
COL6A3 collagen, type VI, alpha 3
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CYB561 cytochrome b561
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
EMP3 epithelial membrane protein 3
ESR1 estrogen receptor 1
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FAM57A family with sequence similarity 57, member A
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GPNMB glycoprotein (transmembrane) nmb
GPX2 glutathione peroxidase 2
H2BFS H2B histone family, member S (pseudogene)
HIST1H2BD histone cluster 1, H2bd
LRRC59 leucine rich repeat containing 59
LTB lymphotoxin beta (TNF superfamily, member 3)
MMP12 matrix metallopeptidase 12
MPP1 membrane protein, palmitoylated 1, 55kDa
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NTS neurotensin
NUCB2 nucleobindin 2
PGC progastricsin (pepsinogen C)
PHACTR2 phosphatase and actin regulator 2
PMP22 peripheral myelin protein 22
PON3 paraoxonase 3
PYGL phosphorylase, glycogen, liver
RGS10 regulator of G-protein signaling 10
RNASET2 ribonuclease T2
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFTPA2 surfactant protein A2
SSR4 signal sequence receptor, delta
STK26 serine/threonine protein kinase 26
TARP TCR gamma alternate reading frame protein
TESC tescalcin
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TOP1 topoisomerase (DNA) I
TRBC1 T cell receptor beta constant 1
TSPAN8 tetraspanin 8
VAMP8 vesicle-associated membrane protein 8

decreased expression

Symbol Name
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C3 aldo-keto reductase family 1, member C3
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ARHGEF40 Rho guanine nucleotide exchange factor (GEF) 40
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5
BAMBI BMP and activin membrane-bound inhibitor
BST2 bone marrow stromal cell antigen 2
CA2 carbonic anhydrase II
CAPN2 calpain 2, (m/II) large subunit
CASP1 caspase 1, apoptosis-related cysteine peptidase
CAST calpastatin
CD36 CD36 molecule (thrombospondin receptor)
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CRABP2 cellular retinoic acid binding protein 2
CRELD2 cysteine-rich with EGF-like domains 2
EFHD1 EF-hand domain family, member D1
EMP1 epithelial membrane protein 1
FABP4 fatty acid binding protein 4, adipocyte
FXYD5 FXYD domain containing ion transport regulator 5
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GOLGA8A golgin A8 family, member A
KLK5 kallikrein-related peptidase 5
KLK6 kallikrein-related peptidase 6
KRT17 keratin 17, type I
KRT6B keratin 6B, type II
KRT7 keratin 7, type II
LY75 lymphocyte antigen 75
MDK midkine (neurite growth-promoting factor 2)
MEF2C myocyte enhancer factor 2C
MTSS1 metastasis suppressor 1
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYOF myoferlin
PDE2A phosphodiesterase 2A, cGMP-stimulated
PEG10 paternally expressed 10
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
SDC1 syndecan 1
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SNAP25 synaptosomal-associated protein, 25kDa
TAC1 tachykinin, precursor 1
TACSTD2 tumor-associated calcium signal transducer 2
TFPI2 tissue factor pathway inhibitor 2
TPM1 tropomyosin 1 (alpha)
TSPO translocator protein (18kDa)
VGLL1 vestigial-like family member 1