BRD-K50140147_NVP-TAE684_MCF7_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

75 genes differentially expressed following the BRD-K50140147_NVP-TAE684_MCF7_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTA1 actin, alpha 1, skeletal muscle
ADCK3 aarF domain containing kinase 3
ADD3 adducin 3 (gamma)
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
BIRC3 baculoviral IAP repeat containing 3
CD24 CD24 molecule
CFLAR CASP8 and FADD-like apoptosis regulator
CKM creatine kinase, muscle
COL4A5 collagen, type IV, alpha 5
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR4 chemokine (C-X-C motif) receptor 4
DIAPH2 diaphanous-related formin 2
EHF ets homologous factor
EIF5A eukaryotic translation initiation factor 5A
FOS FBJ murine osteosarcoma viral oncogene homolog
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GSTP1 glutathione S-transferase pi 1
H1FX H1 histone family, member X
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IFITM1 interferon induced transmembrane protein 1
IRS2 insulin receptor substrate 2
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
L1TD1 LINE-1 type transposase domain containing 1
LEFTY2 left-right determination factor 2
LGALS1 lectin, galactoside-binding, soluble, 1
MB myoglobin
MMP7 matrix metallopeptidase 7
MT1X metallothionein 1X
MYBPC1 myosin binding protein C, slow type
MYL2 myosin, light chain 2, regulatory, cardiac, slow
NQO1 NAD(P)H dehydrogenase, quinone 1
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDE10A phosphodiesterase 10A
PPP1R1A protein phosphatase 1, regulatory (inhibitor) subunit 1A
PTPRM protein tyrosine phosphatase, receptor type, M
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RGS2 regulator of G-protein signaling 2
RTN3 reticulon 3
SAT1 spermidine/spermine N1-acetyltransferase 1
SFRP1 secreted frizzled-related protein 1
SLN sarcolipin
SLPI secretory leukocyte peptidase inhibitor
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
TMEM2 transmembrane protein 2
TNNC1 troponin C type 1 (slow)
TPM2 tropomyosin 2 (beta)
TXNIP thioredoxin interacting protein
VLDLR very low density lipoprotein receptor

decreased expression

Symbol Name
ALDOB aldolase B, fructose-bisphosphate
CCNE2 cyclin E2
CD36 CD36 molecule (thrombospondin receptor)
CDC42 cell division cycle 42
CDKN2A cyclin-dependent kinase inhibitor 2A
CHL1 cell adhesion molecule L1-like
DACH1 dachshund family transcription factor 1
DPP4 dipeptidyl-peptidase 4
EGR1 early growth response 1
EGR3 early growth response 3
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
MAGEA12 melanoma antigen family A12
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MICALL1 MICAL-like 1
PBX3 pre-B-cell leukemia homeobox 3
PPL periplakin
PXDC1 PX domain containing 1
SCGB2A2 secretoglobin, family 2A, member 2
SPP1 secreted phosphoprotein 1
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TMEM176B transmembrane protein 176B
WLS wntless Wnt ligand secretion mediator