BRD-K50140147_NVP-TAE684_HME1_3_h_0.37_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

123 genes differentially expressed following the BRD-K50140147_NVP-TAE684_HME1_3_h_0.37_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ADD3 adducin 3 (gamma)
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
BTG1 B-cell translocation gene 1, anti-proliferative
C7 complement component 7
C8ORF4 chromosome 8 open reading frame 4
CBR3 carbonyl reductase 3
CCNG2 cyclin G2
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CRYAB crystallin, alpha B
DAPK1 death-associated protein kinase 1
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
EAPP E2F-associated phosphoprotein
EFNA1 ephrin-A1
EGR1 early growth response 1
EPHA4 EPH receptor A4
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FRZB frizzled-related protein
GBP2 guanylate binding protein 2, interferon-inducible
GPNMB glycoprotein (transmembrane) nmb
HECA headcase homolog (Drosophila)
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMGB2 high mobility group box 2
HOXA5 homeobox A5
HOXC6 homeobox C6
IGHM immunoglobulin heavy constant mu
IGL immunoglobulin lambda locus
KDM3A lysine (K)-specific demethylase 3A
KLF2 Kruppel-like factor 2
KLF6 Kruppel-like factor 6
KLHL21 kelch-like family member 21
LDB2 LIM domain binding 2
LGALS3 lectin, galactoside-binding, soluble, 3
MAN1A1 mannosidase, alpha, class 1A, member 1
METTL7A methyltransferase like 7A
NEU1 sialidase 1 (lysosomal sialidase)
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NNMT nicotinamide N-methyltransferase
NOTCH2NL notch 2 N-terminal like
NPY1R neuropeptide Y receptor Y1
NR4A2 nuclear receptor subfamily 4, group A, member 2
PAWR PRKC, apoptosis, WT1, regulator
PEG3 paternally expressed 3
PER1 period circadian clock 1
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PNRC1 proline-rich nuclear receptor coactivator 1
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
RGS2 regulator of G-protein signaling 2
SARAF store-operated calcium entry-associated regulatory factor
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB2A2 secretoglobin, family 2A, member 2
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SESN1 sestrin 1
SIK1 salt-inducible kinase 1
SKAP2 src kinase associated phosphoprotein 2
SLC16A4 solute carrier family 16, member 4
TARBP1 TAR (HIV-1) RNA binding protein 1
TCF4 transcription factor 4
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
VCAM1 vascular cell adhesion molecule 1
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
ADRB2 adrenoceptor beta 2, surface
ASPH aspartate beta-hydroxylase
ASS1 argininosuccinate synthase 1
AXL AXL receptor tyrosine kinase
CCND1 cyclin D1
CCNE2 cyclin E2
CDC25A cell division cycle 25A
CDCA4 cell division cycle associated 4
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CSTA cystatin A (stefin A)
DHRS9 dehydrogenase/reductase (SDR family) member 9
DMBT1 deleted in malignant brain tumors 1
DUSP14 dual specificity phosphatase 14
EHD1 EH-domain containing 1
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FOSL1 FOS-like antigen 1
FUT4 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
G0S2 G0/G1 switch 2
GADD45B growth arrest and DNA-damage-inducible, beta
GNAS GNAS complex locus
GOLT1B golgi transport 1B
GRPEL1 GrpE-like 1, mitochondrial (E. coli)
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IL1B interleukin 1, beta
IL1RN interleukin 1 receptor antagonist
JUN jun proto-oncogene
LTF lactotransferrin
MAP2K3 mitogen-activated protein kinase kinase 3
MAT2A methionine adenosyltransferase II, alpha
MGLL monoglyceride lipase
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYO1B myosin IB
NOP16 NOP16 nucleolar protein
NREP neuronal regeneration related protein
NSG1 neuron specific gene family member 1
PDGFA platelet-derived growth factor alpha polypeptide
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PHLDA2 pleckstrin homology-like domain, family A, member 2
PI3 peptidase inhibitor 3, skin-derived
PPIF peptidylprolyl isomerase F
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
PTPRO protein tyrosine phosphatase, receptor type, O
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SNAP25 synaptosomal-associated protein, 25kDa
ST18 suppression of tumorigenicity 18, zinc finger
TMEM158 transmembrane protein 158 (gene/pseudogene)
TSPYL5 TSPY-like 5
WFDC2 WAP four-disulfide core domain 2
WWC1 WW and C2 domain containing 1