BRD-K50140147_NVP-TAE684_HCC515_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

90 genes differentially expressed following the BRD-K50140147_NVP-TAE684_HCC515_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
AKR1C3 aldo-keto reductase family 1, member C3
AQP3 aquaporin 3 (Gill blood group)
CAPN1 calpain 1, (mu/I) large subunit
CAST calpastatin
CCNF cyclin F
CCNG2 cyclin G2
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CHGB chromogranin B
CTSK cathepsin K
DHCR24 24-dehydrocholesterol reductase
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
FOXO4 forkhead box O4
GOLGA8H golgin A8 family, member H
GUSBP11 glucuronidase, beta pseudogene 11
H2BFS H2B histone family, member S (pseudogene)
HBP1 HMG-box transcription factor 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BG histone cluster 1, H2bg
HIST1H2BK histone cluster 1, H2bk
HIST2H2BE histone cluster 2, H2be
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
IRF7 interferon regulatory factor 7
JAM3 junctional adhesion molecule 3
KLHL24 kelch-like family member 24
LGALS3 lectin, galactoside-binding, soluble, 3
LPAR6 lysophosphatidic acid receptor 6
MUC1 mucin 1, cell surface associated
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PDCD6 programmed cell death 6
PMP22 peripheral myelin protein 22
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
STAT1 signal transducer and activator of transcription 1, 91kDa
TMEM140 transmembrane protein 140
TSC22D3 TSC22 domain family, member 3
TSPAN4 tetraspanin 4
TXNIP thioredoxin interacting protein
ZDHHC11 zinc finger, DHHC-type containing 11

decreased expression

Symbol Name
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
ARL4C ADP-ribosylation factor-like 4C
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
CCND1 cyclin D1
CDC6 cell division cycle 6
CDK1 cyclin-dependent kinase 1
CKAP4 cytoskeleton-associated protein 4
CKB creatine kinase, brain
DNM1L dynamin 1-like
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
ENOPH1 enolase-phosphatase 1
EPHB2 EPH receptor B2
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FOSL1 FOS-like antigen 1
G0S2 G0/G1 switch 2
GAL galanin/GMAP prepropeptide
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
HAT1 histone acetyltransferase 1
ITGA6 integrin, alpha 6
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3
KIAA0101 KIAA0101
LEF1 lymphoid enhancer-binding factor 1
MCM6 minichromosome maintenance complex component 6
MECOM MDS1 and EVI1 complex locus
MSX1 msh homeobox 1
ODC1 ornithine decarboxylase 1
PDIA6 protein disulfide isomerase family A, member 6
PHLDA1 pleckstrin homology-like domain, family A, member 1
PODXL podocalyxin-like
PSPH phosphoserine phosphatase
PTRF polymerase I and transcript release factor
PTX3 pentraxin 3, long
RBP1 retinol binding protein 1, cellular
RBP4 retinol binding protein 4, plasma
RFC2 replication factor C (activator 1) 2, 40kDa
RRM2 ribonucleotide reductase M2
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
TGFBI transforming growth factor, beta-induced, 68kDa
TMEM158 transmembrane protein 158 (gene/pseudogene)
TYMS thymidylate synthetase
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1